Is There Any Correlation between Insulin Resistance and Nitrate Plasma Concentration in White Coat Hypertensive Patients?

Marchi-Alves, Leila Maria; Cárnio, Evelin Capellari

doi:10.4061/2009/376735

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Our analyses suggest that nitrate and nitrite concentrations mark different processes in vivo. An increased intake of nitrate is associated with lower lipid accumulation and inflammation and promotes insulin secretion, glucose uptake, mitochondrial efficiency and browning of adipose tissue [7,15,18,[36][37][38]. Therefore, increased nitrate concentrations could play an important role in attenuating MetS and T2DM.…”

Section: Discussionmentioning

confidence: 99%

“…However, there is conflicting data about the protective effects of nitrate and nitrite on oxidative stress in patients with T2DM [13]. In most human studies describing the association between nitrate and nitrite with markers of the MetS, the dietary contribution to circulating nitrate/nitrite levels was not taken into consideration [14][15][16]. Dietary nitrate is metabolized to nitrite by the oral microbial flora and may produce NO under certain conditions, and nitrate intake can be elevated with increased consumption of green leafy vegetables and beetroots [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Plasma Nitrate Levels Are Related to Metabolic Syndrome and Are Not Altered by Treatment with DPP-4 Inhibitor Linagliptin: A Randomised, Placebo-Controlled Trial in Patients with Early Type 2 Diabetes Mellitus

et al. 2021

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The depletion of nitrate and nitrite, stable nitric oxide (NO) end-products, promotes adipose tissue dysfunction and insulin resistance (IR). Dipeptidyl peptidase-4 (DPP-4) inhibitors have the potentially beneficial side effect of increasing NO availability. In this study, nitrate and nitrite levels and the effects of DPP-4 inhibitor linagliptin were investigated in relation to metabolic syndrome (MetS) markers. Treatment-naive patients with early type 2 diabetes mellitus (T2DM) (n = 40, median age 63 IQR (55–67) years, 63% male, mean HbA1c 45 ± 4.4 mmol/mol) were randomized (1:1) to linagliptin (5 mg/day) or placebo. MetS-related markers (body mass index (BMI), triglycerides, HOMA-IR, gamma-glutamyltransferase (GGT), C-reactive protein (CRP), and adiponectin), plasma levels of nitrate, nitrite, total free thiols (TFT) and vegetable intake were estimated at baseline and after 4 and 26 weeks of treatment. Plasma nitrate, but not nitrite, correlated positively with vegetable intake (r = 0.38, p = 0.018) and was inversely associated with HOMA-IR (r = −0.44, p = 0.006), BMI (r = −0.35, p = 0.028), GGT (r = −0.37, p = 0.019) and CRP (r = −0.34, p = 0.034). The relationship between nitrate and HOMA-IR remained significant after adjusting for BMI, CRP, vegetable intake and GGT. With stable vegetable intake, nitrate and nitrite, TFT, adipokines and CRP did not change after 26 weeks of linagliptin treatment. While plasma nitrate is inversely associated with MetS, linagliptin treatment does not significantly influence nitrate and nitrite concentrations, oxidative stress, adipose tissue function and systemic inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasma Nitrate Levels Are Related to Metabolic Syndrome and Are Not Altered by Treatment with DPP-4 Inhibitor Linagliptin: A Randomised, Placebo-Controlled Trial in Patients with Early Type 2 Diabetes Mellitus

et al. 2021

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“…NO is rela vely unstable in the presence of oxygen and rapidly autoxidates, making its concentra on diffi cult to measure. The indirect determina on of the NO concentra on based on the concentra on of nitrate has been used successfully (12) . Findings involving salivary NO levels in physiologically normal mucosa and oral mucosal lesions prompted the use of this parameter in this study, which aimed to determine whether clinical oral cavity assessment indicators are associated with the NO concentra on determined indirectly using the nitrate concentra on in pa ents with oncologic and hematologic diseases before the start of intravenous chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Exame da cavidade bucal de pacientes com câncer: avaliação clínica e dosagem indireta de óxido nítrico

Carvalho

Cárnio

Khouri

et al. 2013

Rev. esc. enferm. USP

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RESUMONeste estudo buscou-se verifi car associação entre avaliação clínica da cavidade oral (pelos Índices de dentes Cariados, Perdidos e Obturados e Índice de Higiene Oral -Simplifi cado) e a determinação indireta de óxido nítrico em pacientes com patologias onco-hematológicas. Trata-se de estudo observacional, no qual foram incluídos vinte sujeitos internados, diagnos cados com Leucemia (35%), Linfoma (50%), Mieloma (15%), em avaliação para início de quimioterapia, sendo que 50% apresentaram normalidade da condição bucal (sem lesões ou traumas); a maioria apresentou higiene sa sfatória (35%) ou regular (35%), porém, 30% veram higiene defi ciente ou péssima. A expressão indireta do óxido nítrico variou de 13,34 a 257. O óxido nítrico não apresentou associação com os outros parâmetros; houve grande variabilidade de seus valores. Novos estudos são necessários, em especial pela potencialidade deste indicador na detecção precoce de alterações bucais. DESCRITORES Óxido nítrico Higiene bucal Quimioterapia Cuidados de enfermagem ABSTRACTThis observa onal study aimed to verify the associa on between the clinical state of the oral cavity (based on the Index of Decayed, Missing, and Filled Teeth and the Simplifi ed Oral Hygiene Index) and the indirectly determined nitric oxide level in pa ents with oncologic and hematologic diseases. This study included 20 hospitalized pa ents who were in the evalua on phase prior to star ng chemotherapy and who had been diagnosed with leukemia (35%), lymphoma (50%) or myeloma (15%). Fi y percent of these pa ents had normal oral health (no injury or trauma), and most had sa sfactory (35%) or typical (35%) hygiene, but 30% had poor or very poor hygiene. The indirectly measured levels of nitric oxide ranged from 13.34 to 257. The nitric oxide level was not associated with other parameters, and there was great variability in its level. Further studies are necessary given the poten al of using this indicator in the early detecon of oral diseases. DESCRIPTORS

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Decoding white coat hypertension

Bloomfield¹,

Park²

2017

WJCC

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There is arguably no less understood or more intriguing problem in hypertension that the “white coat” condition, the standard concept of which is significantly blood pressure reading obtained by medical personnel of authoritative standing than that obtained by more junior and less authoritative personnel and by the patients themselves. Using hospital-initiated ambulatory blood pressure monitoring, the while effect manifests as initial and ending pressure elevations, and, in treated patients, a low daytime profile. The effect is essentially systolic. Pure diastolic white coat hypertension appears to be exceedingly rare. On the basis of the studies, we believe that the white coat phenomenon is a common, periodic, neuro-endocrine reflex conditioned by anticipation of having the blood pressure taken and the fear of what this measurement may indicate concerning future illness. It does not change with time, or with prolonged association with the physician, particularly with advancing years, it may be superimposed upon essential hypertension, and in patients receiving hypertensive medication, blunting of the nighttime dip, which occurs in about half the patients, may be a compensatory mechanisms, rather than an indication of cardiovascular risk. Rather than the blunted dip, the morning surge or the widened pulse pressure, cardiovascular risk appears to be related to elevation of the average night time pressure.

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Is There Any Correlation between Insulin Resistance and Nitrate Plasma Concentration in White Coat Hypertensive Patients?

Cited by 3 publications

References 20 publications

Plasma Nitrate Levels Are Related to Metabolic Syndrome and Are Not Altered by Treatment with DPP-4 Inhibitor Linagliptin: A Randomised, Placebo-Controlled Trial in Patients with Early Type 2 Diabetes Mellitus

Plasma Nitrate Levels Are Related to Metabolic Syndrome and Are Not Altered by Treatment with DPP-4 Inhibitor Linagliptin: A Randomised, Placebo-Controlled Trial in Patients with Early Type 2 Diabetes Mellitus

Exame da cavidade bucal de pacientes com câncer: avaliação clínica e dosagem indireta de óxido nítrico

Decoding white coat hypertension

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