Is there any difference between endometrial hyperplasia and endometrial carcinoma in terms of expression of TRPM2 and TRPM7 ion channels?

Yalçın, Emre

doi:10.3906/sag-1810-176

Cited by 10 publications

(14 citation statements)

References 41 publications

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“…Histoscore was calculated for immunohistochemical staining. Histoscore = distribution (0.1 = under 25%; 0.4 = 26-50%; 0.6 = 50-75%; 0.9 = 76-100%) × intensity (0 = no staining; + 0.5 = very little staining; + 1 = little staining; + 2 = medium staining; + 3 = very strong staining) [21].…”

Section: Histological Evaluationsmentioning

confidence: 99%

Transient receptor potential melastatin 2 ion channel activity in ovarian hyperstimulation syndrome physiopathology

Şanlı¹,

Atılgan²,

Kuloğlu³

et al. 2021

Turk J Med Sci

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Background/aim: Ovarian hyperstimulation syndrome (OHSS) is a complication of ovarian stimulation with increased vascular endothelial growth factor (VEGF) and vascular permeability in ovarian tissue. Transient receptor potential melastatin 2 (TRPM2) is known to be associated with angiogenesis and vascular permeability. In this experimental study, we aimed to investigate the activity of TRPM2 in the development of OHSS. Materials and Methods: Fourteen immature female rats were divided into two groups. Group 1 was the control group, and Group 2 was the OHSS group which was exposed to 10 IU of subcutaneous application of FSH for four days and 30 IU of human chorionic gonadotropin (hCG) on 5 th day. At the end of the experiment, the ovaries were removed. The right ovarian tissues were stored in 10% formol for histopathological and immunohistochemical examination. The left ovarian tissues were stored at-80°C for biochemical examinations. VEGF, tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA) levels were measured in the ovarian tissue. Congestion, edema, apoptosis and TRPM2 immunoreactivity were evaluated. Results: There was a significant increase in ovarian weight in the OHSS group compared to the control group. There was a significant increase in congestion, edema, apoptosis and TRPM2 immunoreactivity in the OHSS group. A significant increase in tissue levels of VEGF, TNF-α and MDA was also found in the OHSS group compared to the control group. Conclusions: As a result of our experiment, Increased TRPM2 immunoreactivity on hyperstimulated rat ovary may be the reason or result of edema and congestion. Further studies are needed to discuss our results.

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Section: Histological Evaluationsmentioning

confidence: 99%

Transient receptor potential melastatin 2 ion channel activity in ovarian hyperstimulation syndrome physiopathology

Şanlı¹,

Atılgan²,

Kuloğlu³

et al. 2021

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…Extensity of the staining was taken as the basis when evaluating the immunohistochemical staining. A histoscore was derived from the distribution (0.1 = under 25%; 0.4 = 26-50%; 0.6 = 50-75%; 0.9 = 76-100%) and the intensity (0 = no staining; +0.5 = very little staining; +1 = little staining; +2 = medium staining; +3 = very strong staining) of the staining immunoreactivity (Histoscore = distribution × intensity) [24].…”

Section: Immunohistochemical Examinationmentioning

confidence: 99%

Comparison of the efficacy between bilateral proximal tubal occlusion and total salpingectomy on ovarian reserve and the cholinergic system: an experimental study

et al. 2020

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Compared to G1 and G3, the number of corpus luteum with secondary follicles was significantly lower in G2, whereas the number of ovarian cysts and fibrosis and apoptosis scores increased significantly. The CHRM1 immunoreactivity was significantly lower in G2 than in G1 and G3. Conclusions: Compared to the bilateral proximal tubal occlusion performed by using bipolar cautery, bilateral total salpingectomy in rats leads to a significant damage in ovarian histopathology and the cholinergic system.

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“…Recent reports suggest that the activity of the TRPM7 ion channel may indicate the progression from endometrial hyperplasia to early-stage EC. [2] While early-stage EC cases can often be successfully treated through a hysterectomy, advanced EC poses significant challenges with a bleak prognosis and a lack of reliable markers and effective treatment options. However, advancements in targeted chemotherapeutic approaches, such as immunotherapy targeting immune checkpoints and novel chemotherapy strategies, have emerged based on the molecular understanding of EC.…”

Section: Introductionmentioning

confidence: 99%

Identification of immunogenic cell death-related subtypes used for predicting survival and immunotherapy of endometrial carcinoma through a bioinformatics analysis

Liu

Luo

et al. 2023

Medicine

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Immunogenic cell death (ICD) is a unique phenomenon that can trigger comprehensive, adaptive immune responses through damage-associated molecular patterns, offering a promising avenue for tumor immunotherapy. However, the role of ICD-related genes and their correlation with endometrial carcinoma (EC), the most prevalent gynecologic malignancy, remains unclear. This study examined genetic, transcriptional, and clinical data of EC obtained from the Cancer Genome Atlas database. Unsupervised clustering analysis was utilized to identify distinct ICD clusters based on the expression of ICD-related genes. Regarding the different clusters, their survival analysis, assessment of the immune microenvironment, immune cell infiltration, immune checkpoint analysis, and tumor mutation burden analysis were performed. Furthermore, an ICD risk signature was established using univariate Cox regression and least absolute shrinkage and selection operator analysis. The Chi-square test was employed to investigate the relationship between the ICD score and clinical features. Multiple computational analytical tools were used to assess immune annotation, somatic mutations, tumor mutation burden, and response to immunotherapy and chemotherapy drugs in different ICD score groups. Two ICD clusters were identified, indicating that the ICD-high cluster was associated with improved prognosis, abundant immune cell infiltration, and enrichment of pathways related to immunologic activation. Moreover, the ICD risk signature showed predictive value for the immune microenvironment, immunotherapy response, chemotherapy susceptibility, and prognosis in EC. Our findings offer novel insights into personalized treatment strategies for EC patients.

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Is there any difference between endometrial hyperplasia and endometrial carcinoma in terms of expression of TRPM2 and TRPM7 ion channels?

Cited by 10 publications

References 41 publications

Transient receptor potential melastatin 2 ion channel activity in ovarian hyperstimulation syndrome physiopathology

Transient receptor potential melastatin 2 ion channel activity in ovarian hyperstimulation syndrome physiopathology

Comparison of the efficacy between bilateral proximal tubal occlusion and total salpingectomy on ovarian reserve and the cholinergic system: an experimental study

Identification of immunogenic cell death-related subtypes used for predicting survival and immunotherapy of endometrial carcinoma through a bioinformatics analysis

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