Is there any evidence for a post-tubal sterilization syndrome?

Gentile, G; Kaufman, Steven C.; Helbig, Donald W.

doi:10.1016/s0015-0282(97)00229-x

Cited by 61 publications

(49 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, although tubal sterilization is a common, effective and safe contraception method, one potential complication is post-tubal ligation syndrome. Post-tubal ligation syndrome is characterized by one or more sequelae post-surgery, including abnormal bleeding or pain, changes in sexual behavior or emotional health, exacerbation of premenstrual symptoms, menstrual disturbances and early menopause (Williams et al, 1951;Muldoon, 1972;Stock, 1978;Cooper, 1983;Gentile et al, 1998;Grynnerup et al, 2013;Ye et al, 2015). A few groups have reported luteal deficiency or a reduction in progesterone production after tubal ligation (Donnez et al, 1980;Alvarez-Sanchez et al, 1981;Corson et al, 1981;Donnez et al, 1981;Helm and Sjöberg, 1986).…”

Section: Introductionmentioning

confidence: 99%

Human fallopian tube epithelium co-culture with murine ovarian follicles reveals crosstalk in the reproductive cycle

Zhu

Rashedi

et al. 2016

Mol. Hum. Reprod.

View full text Add to dashboard Cite

STUDY QUESTION: Do interactions between human fallopian tube epithelium and murine follicles occur during an artificial reproductive cycle in a co-culture system in vitro?SUMMARY ANSWER: In a co-culture system, human fallopian tissues responded to the menstrual cycle mimetic by changes in morphology and levels of secreted factors, and increasing murine corpus luteum progesterone secretion.WHAT IS KNOWN ALREADY: The entire fallopian tube epithelium, including ciliated and secretory cells, can be regulated in the reproductive cycle. Currently, there are no in vitro culture models that can monitor fallopian tissues in real time in response to factors produced by the ovary. In addition, there are no reports on the impact of fallopian tissue on ovarian function during the menstrual cycle.STUDY DESIGN, SAMPLES/MATERIALS, METHODS: Human fallopian tissue (n = 24) was obtained by routine hysterectomies from women (aged 26-50 years, mean age = 43.6) who had not undergone exogenous hormonal treatment for at least 3 months prior to surgery. CD1 female mice were used for ovarian follicle isolation. The human fallopian epithelium layers were either co-cultured with five murine multilayer secondary follicles (150-180 μm follicles, encapsulated in one alginate gel bead) for 15 days or received stepwise steroid hormone additions for 13 days. The fallopian tissue morphology and cilia beating rate, as measured by an Andor Spinning Disk Confocal, were investigated. Oviduct-specific glycoprotein 1 (OVGP1), human insulin-like growth factor 1 (hIGF1), vascular endothelial growth factor A (VEGF-A) and interleukin 8 (IL8) as biological functional markers were measured either by ELISA or western blot to indicate dynamic changes in the fallopian epithelium during the reproductive cycle generated by mouse follicles or by stepwise steroid hormone induction. Three or four patients in each experiment were recruited for replicates. Data were presented as mean ± SD and further analyzed using one-way ANOVA followed by Tukey's multiple comparisons test. MAIN RESULTS AND THE ROLE OF CHANCE:The cultured fallopian tube epithelium responded to exogenous steroid hormone stimulation, as demonstrated by enhanced cilia beating rate (~25% increase, P = 0.04) and an increase in OVGP1 secretion (P = 0.02) in response to 1 nM estradiol (E 2 ) treatment when compared with 0.1 nM E 2 . Conversely, 10 nM progesterone plus 1 nM E 2 suppressed cilia beating rate by~30% (P = 0.008), while OVGP1 secretion was suppressed by 0.1 nM E 2 plus 50 nM progesterone (P = 0.002 versus 1 nM E 2 alone). Human fallopian tube epithelium was co-cultured with murine secondary follicles to mimic the human menstrual cycle. OVGP1 and VEGF-A secretion from fallopian tissue was similar with stepwise hormone treatment and when cultured with murine follicles. However, the secretion patterns of hIGF1 and IL8 differed in the luteal phase when comparing steroid treatment with follicle co-culture. In co-culture, hIGF1 secretion was suppressed in the luteal versus follicular phase (P = 0.005)...

show abstract

Section: Introductionmentioning

confidence: 99%

Human fallopian tube epithelium co-culture with murine ovarian follicles reveals crosstalk in the reproductive cycle

Zhu

Rashedi

et al. 2016

Mol. Hum. Reprod.

View full text Add to dashboard Cite

show abstract

“…The alteration of the ovarian function by sterilization has been hypothesized to be responsible for menstrual abnormalities and hormonal disturbances that characterize the so-called posttubal ligation syndrome. 3,4 The logic behind this theory is that the vascularization of the ovaries by either ovarian artery or the uteroovarian anastomoses as well as the fallopian tube destruction reduce the utero-ovarian arterial blood flow in the mesosalpinx, which leads to ovarian tissue damage. 4 In 1987, Riedel HH et al 5 found that the levels of estrogen and progesterone decrease after fallopian tube sterilization and hysterectomy.…”

Section: Introductionmentioning

confidence: 99%

Tubal ligation and early menopause: a case-control study

Tayeh¹,

Naba²,

Habib³

et al. 2018

OGIJ

View full text Add to dashboard Cite

Submit Manuscript | http://medcraveonline.com Abbreviations: BMI, body mass index; FSH, follicle stimulating hormone; HDF, hôtel-dieu de france BackgroundThe effect of the use of tubal sterilization as a birth control method on ovarian function, ovarian reserve and menopausal age is questionable. In fact, bilateral salpingectomy or tubal ligation 1 and conservative abdominal hysterectomy 2 were sometimes related to decrease ovarian function and premature menopause. The decrease of hormonal secretion will cause endocrine disorders manifested by decreased libido, vaginal dryness, mood swings and vasomotor symptoms. The alteration of the ovarian function by sterilization has been hypothesized to be responsible for menstrual abnormalities and hormonal disturbances that characterize the so-called posttubal ligation syndrome.3,4 The logic behind this theory is that the vascularization of the ovaries by either ovarian artery or the uteroovarian anastomoses as well as the fallopian tube destruction reduce the utero-ovarian arterial blood flow in the mesosalpinx, which leads to ovarian tissue damage. 4 In 1987, Riedel HH et al. 5 found that the levels of estrogen and progesterone decrease after fallopian tube sterilization and hysterectomy.5 Nonetheless, Kusche M et al. 6 in 1994 contradicted this finding by stating that no endocrinological parameters in the perimenopause were found, neither did cycle anomalies and ovarian deficiency symptoms in terms of climacteric complaints occur earlier, nor did early onset of menopause occur more often in the operated group. In this context, the objective of the present study was to compare age at menopause between the women having already undergone tubal ligation and the control group having intact fallopian tubes. Also, we review literature about the long-term safety of tubal ligation. Methods Study settings and populationFor the purpose of this case-control study, we retrospectively reviewed the medical records of all women (cases) who had previously undergone bilateral tubal ligation between 1970 and 2010 at the department of Obstetrics and Gynecology, Hôtel-Dieu de France (HDF) University Hospital, Beirut, Lebanon.More than 200 patients were contacted of whom many were found to have changed their phone numbers. Eligible cases had to be menopaused; menopause was defined as having amenorrhea for more than 12 months with or without symptoms related to hormonal depletion. Exclusion criteria were patients who were operated for bilateral ovariectomy or salpingectomy or hysterectomy before their physiological menopause, and patients who got chemotherapy, radiation therapy or any hormonal therapy that could influence their reproductive function and alter their normal evolution towards menopause.The 50 cases were then compared to 50 randomly chosen menopaused women (controls) from the department of Obstetrics and Gynecology at HDF, who did not get any tubal ligation or gynecological surgeries (intact tubes, ovaries and uterus) but meeting the same eligibility criteria as the cases....

show abstract

“…A ligadura tubária é o método anticoncepcional mais popular no mundo 1,2 . No Brasil, 31,1% das mulheres com idade entre 15 e 54 anos estavam esterilizadas.…”

Section: Introductionunclassified

“…Em São Paulo, a esterilização feminina não sofreu tal incremento e tem se mantido num patamar de pouco mais de 30% 4 . Ao lado da grande eficácia, a laqueadura tubária pode provocar efeitos colaterais, destacando-se as anormalidades do fluxo menstrual, dores, alterações no comportamento sexual e emocional 2,5 ,constituindo a chamada síndrome pós-ligadura. No entanto, a maioria dos estudos que avaliaram a evolução clínica de mulheres submetidas à ligadura tubária não evidenciou qualquer tipo de distúrbio menstrual ou apenas discretas alterações [6][7][8] .…”

unclassified

Peso do útero após ligadura no ramo ovariano do vaso uterino

Prado¹,

Aoki²,

Aldrighi³

2007

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

A ligadura tubária é o método anticoncepcional mais popular no mundo 1,2 . No Brasil, 31,1% das mulheres com idade entre 15 e 54 anos estavam esterilizadas. Este número cresceu para 40,1% após dez anos, caracterizando-a como o método contraceptivo mais usado no País 3. Em São Paulo, a esterilização feminina não sofreu tal incremento e tem se mantido num patamar de pouco mais de 30% 4 . Ao lado da grande eficácia, a laqueadura tubária pode provocar efeitos colaterais, destacando-se as anormalidades do fluxo menstrual, dores, alterações no comportamento sexual e emocional 2,5 ,constituindo a chamada síndrome pós-ligadura. No entanto, a maioria dos estudos que avaliaram a evolução clínica de mulheres submetidas à ligadura tubária não evidenciou qualquer tipo de distúrbio menstrual ou apenas discretas alterações 6-8 . Os distúrbios menstruais foram descritos pela primeira vez por Willians et al. 9; neste estudo, os autores compararam 200 mulheres submetidas a ligadura tubária com 5216 pacientes não submetidas ao procedimento (1994 ginecológicas e 3222 obstétricas), durante um período de um a dez anos, e constataram que 19% das pacientes ginecológicas, 5% das obstétricas e 24% das esterilizadas apresentaram distúrbios menstruais, definidos como maior prevalência de sangramento intermenstrual e aumento no fluxo menstrual.Posteriormente, Muldoon 5 observou que 374 mulheres esterilizadas, ou 43% delas, necessitaram de tratamento ginecológico complementar, 19% de histerectomia e 6% de outras cirurgias ginecológicas. Diferentemente, Rulin et al.7 constataram que importante parcela dos distúrbios menstruais foi referida previamente à ligadura, principalmente em mulheres usuárias de contraceptivos orais combinados. Outra controvérsia relacionou-se ao tempo de aparecimento dos sintomas; assim, Kassonde & Bonnar 10 não constataram alterações menstruais até 12 meses após a ligadura, enquanto outros estudos 11,12 observaram-nas após dois anos da cirurgia. Ademais, o risco de internação hospitalar decorrente do sangramento menstrual excessivo foi duas vezes maior em mulheres submetidas a laqueadura do que nas que não foram submetidas ao procedimento 13 . Shobeiri e Atashkhoii 14 sugerem que as irregularidades menstruais após ligadura tubária são mais freqüentes em mulheres jovens e que tais distúrbios são mais freqüentes durante o período de 12 meses após o procedimento, fortemente relacionados a fatores psicológicos.Várias hipóteses tentam justificar os mecanismos envolvidos na gênese das alterações menstruais; duas são comumente relatadas: aumento da pressão na microcirculação intra-ovárica 15,16 e lesão vascular. Na lesão vascular, a hipótese mais aceita, supõe-se que ocorre comprometimento dos ramos ováricos da artéria uterina, que, ao gerar insuficiente irrigação dos ovários, pode desencadear perturbações sobre a esteroidogênese gonadal 13,17 . Além dos aspectos controversos referidos, há uma evidente escassez de estudos na literatura pertinente às alterações menstruais após ligadura tubária. Tais fatos nos motivaram a estu...

show abstract

Is there any evidence for a post-tubal sterilization syndrome?

Cited by 61 publications

References 43 publications

Human fallopian tube epithelium co-culture with murine ovarian follicles reveals crosstalk in the reproductive cycle

Human fallopian tube epithelium co-culture with murine ovarian follicles reveals crosstalk in the reproductive cycle

Tubal ligation and early menopause: a case-control study

Peso do útero após ligadura no ramo ovariano do vaso uterino

Contact Info

Product

Resources

About