Is There Any Role for the Choroid in Glaucoma?

Goharian, Iman; Sehi, Mitra

doi:10.1097/ijg.0000000000000166

Cited by 30 publications

(22 citation statements)

References 123 publications

(137 reference statements)

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“…22,23 In addition, some studies have reported a lack of correlation between choroidal thickness and visual field defect 19,23,29,41,42 or retinal nerve fiber layer thickness. 19,25,33,34 As the real relationship between GON and choroidal thickness is not fully understood, 51 we present a detailed discussion to shed more light on the relationship between them and to try to explain why choroidal thickness of the macular and peripapillary regions is not significantly altered in OAG in comparison with that in the normal controls.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness and Open-Angle Glaucoma: A Meta-Analysis and Systematic Review

Zhang

Min

Wang

et al. 2016

Journal of Glaucoma

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Our meta-analysis found no significant difference in the choroidal thickness both under the fovea and around the optic nerve head between OAG patients and controls. On the basis of the anatomic features of blood supply in optic nerve head, it is plausible that the choroidal thickness is not an appropriate parameter to evaluate the damage of OAG, and choroidal thinning may not be an important component of glaucomatous optic neuropathy.

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Section: Discussionmentioning

confidence: 99%

Choroidal Thickness and Open-Angle Glaucoma: A Meta-Analysis and Systematic Review

Zhang

Min

Wang

et al. 2016

Journal of Glaucoma

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“…The total number of people aged 40–80 years diagnosed as having primary open-angle glaucoma (POAG) is predicted to increase to 79.76 million in 2040, approximately 85% of the glaucomatous population [1]. The pathogenesis of open-angle glaucoma (OAG) has not been fully interpreted yet and accumulating evidence suggests that it is associated with the reduced blood perfusion to the optic nerve [2–4]. As the peripapillary choroid branches are the main source of blood supply to this region, it has been proposed that an abnormal choroid circulation could be involved in the occurrence of glaucomatous optic neuropathy.…”

Section: Introductionmentioning

confidence: 99%

Peripapillary Choroidal Thickness and Open-Angle Glaucoma: A Meta-Analysis

Lin

Huang

Xie

et al. 2016

Journal of Ophthalmology

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Purpose. To investigate the potential relationship between open-angle glaucoma (OAG) and peripapillary choroidal thickness (PPCT). Materials and Methods. Relevant publications were searched systematically through various databases from inception to January 2016. Studies comparing PPCT in OAG patients and healthy controls were retrieved. All qualified articles were analyzed using Stata 14.0 and Revman 5.3 software. Results. A total of 13 studies were identified for inclusion. There was a significant reduction of average PPCT in OAG patients compared to control participants (WMD = −24.07, 95% CI: −34.29, −13.85). Reduction of PPCT was significant in the superior (WMD = −28.87, 95% CI: −44.96, −12.78) and nasal (WMD = −21.75, 95% CI: −41.52, −1.98) sectors, but there was no significant reduction of PPCT in the inferior (WMD = −9.57, 95% CI: −36.55, 17.40) and temporal (WMD = −13.85, 95% CI: −35.40, 7.70) sectors. No obvious publication bias was detected. Conclusions. This meta-analysis suggests that open-angle glaucoma patients have significantly decreased peripapillary choroidal thickness compared to healthy individuals. Peripapillary choroidal thickness measured by optical coherence tomography may be an important parameter to consider in open-angle glaucoma.

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“…of the blood flow within the eye, and is the major supplier of nutrients to the optic nerve head. Therefore, abnormal choroidal blood supply is considered a potential factor responsible for the development of glaucomatous optic neuropathy (5). Recent advancements in optical coherence tomography (OCT) technology have enabled researchers to detect choroidal changes more accurately (6).…”

Section: Introductionmentioning

confidence: 99%

Macular choroidal thickness in patients with ocular hypertension as assessed by enhanced depth imaging optical coherence tomography

Topçu-Yılmaz¹

2019

Beyoglu Eye J

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The aim of this study was to evaluate the macular choroidal thickness (CT) in patients with ocular hypertension (OHT) using spectral domain optical coherence tomography (SD-OCT) and compare the results with healthy individuals. Methods: Thirty eyes of 30 patients newly diagnosed with OHT and 24 eyes of 24 healthy controls were included in this cross-sectional study. After a detailed ophthalmological examination, macular CT was measured with enhanced depth imaging optical coherence tomography (EDI-OCT) (Cirrus HD-OCT, Carl Zeiss Meditec AG, Jena, Germany) at the fovea and at positions 500 µ, 1000 µ, 1500 µ nasal and temporal to the fovea. The Mann-Whitney U test was used to compare the CT measurements between groups. The correlation between the mean deviation, pattern standard deviation, and retinal nerve fiber layer thickness (RNFL) and CT was evaluated with the Spearman correlation coefficient. Statistical significance was accepted as p<0.05. Results: The mean CT in the OHT group was significantly thinner than that of the controls at locations 1000 µ (250.13±69.53µ vs 275.92±47.34µ; p=0.02) and 1500µ (236.03±65.44µ vs 265.46±47.56µ; p=0.009) temporal to the fovea. The CT at the other measurement points was also thinner in eyes with OHT, but the difference failed to reach statistical significance. A moderately negative correlation was detected between the mean deviation and CT at locations 1000µ (r=-0.42; p=0.03) and 1500µ (r=-0.44; p=0.02) temporal to the fovea There was a moderate correlation between the average RNFL thickness and CT at locations 500µ (r=0.44; p=0.03), 1000µ (r=0.42; p=0.04) and 1500µ (r=0.56; p=0.005) temporal to the fovea. Conclusion: In the present study, the macular CT was thinner in patients with OHT and this thinning was statistically significant at the temporal macula. A longitudinal, prospective study involving multiple EDI-OCT measurements is required to further understand the relationship.

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Is There Any Role for the Choroid in Glaucoma?

Cited by 30 publications

References 123 publications

Choroidal Thickness and Open-Angle Glaucoma: A Meta-Analysis and Systematic Review

Choroidal Thickness and Open-Angle Glaucoma: A Meta-Analysis and Systematic Review

Peripapillary Choroidal Thickness and Open-Angle Glaucoma: A Meta-Analysis

Macular choroidal thickness in patients with ocular hypertension as assessed by enhanced depth imaging optical coherence tomography

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