Is there any role of latent toxoplasmosis in schizophrenia disease?

Karabulut, Nuran; Bïlgïç, Serkan; Gürok, Mehmet Gürkan; Karaboğa, Fatih

doi:10.1016/j.jcma.2015.06.007

Cited by 24 publications

(20 citation statements)

References 17 publications

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“…Previous studies from Iran arrived at inconsistent results regarding the association between schizophrenia and T. gondii seropositivity . Recent research from other countries failed to show a significant association between schizophrenia and T. gondii infection .…”

Section: Discussionmentioning

confidence: 96%

“… of 38 studies showed that individuals with schizophrenia have an increased prevalence of antibodies to T. gondii ; the overall odds ratio was 2.71 (95% CI: 1.93–3.80). However, other studies failed to demonstrate a significant association between schizophrenia and toxoplasmosis . Several investigators in various parts of Iran have sought to determine the association of schizophrenia with T. gondii seroprevalence.…”

Section: Introductionmentioning

confidence: 99%

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Association of Toxoplasma gondii infection with schizophrenia and its relationship with suicide attempts in these patients

Ansari-Lari

Farashbandi

Mohammadi

2017

Tropical Med Int Health

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Association of Toxoplasma gondii infection with schizophrenia and its relationship with suicide attempts in these patients

Ansari-Lari

Farashbandi

Mohammadi

2017

Tropical Med Int Health

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“…Out of the 2,604 different articles in English, French, Spanish, Portuguese, Chinese, and Russian, initially identified for co-morbidities between mental health and chronic physical diseases, and for comorbidities between mental health and neurotropic parasitic diseases, 18 articles were included in our meta-analysis ( Figure 1). Among these 18 articles of co-morbidity studies on mental disorders and neurotropic parasitic diseases [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65] published between 1997 and 2016 and meeting our inclusion criteria, two were prevalence studies in individuals with neurotropic parasitic diseases who were screened for mental disorders, and sixteen were analytical studies in individuals with mental disorders who were screened for neurotropic parasitic diseases (Table 2 and Table 3).…”

Section: General Resultsmentioning

confidence: 99%

Associations of mental disorders and neurotropic parasitic diseases: a meta-analysis in developing and emerging countries

Daré

Bruand

Gérard

et al. 2019

Preprint

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Although they are declining worldwide, neurotropic parasitic diseases are still common in developing and emerging countries. The aim of this study was to estimate the pooled prevalence and pooled association measures of comorbidities between mental disorders (anxiety, depression, bipolar disorder, and schizophrenia) and neurotropic parasitic diseases (malaria, cysticercosis, toxoplasmosis, human African trypanosomiasis, Chagas disease, and human toxocariasis) in developing and emerging countries. As the first meta-analysis on this topic, this study was performed in accordance with PRISMA guidelines. The protocol was registered in PROSPERO (N°CRD42017056521). The Medline, Embase, Lilacs, and Institute of Epidemiology and Tropical Neurology databases were used to search for articles without any restriction in language or date. We evaluated the quality of studies independently by two investigators using the Downs and Black assessment grid and pooled estimates using the random-effects method from CMA (Comprehensive Meta Analysis) Version 3.0. In total, 18 studies published between 1997 and 2016 met our inclusion criteria. We found that the prevalence of anxiety and depression in people suffering from Chagas disease and/or neurocysticercosis was 44.9% (95% CI, 34.4 – 55.9). In 16 pooled studies that included 1,782 people with mental disorders and 1,776 controls, toxoplasmosis and/or toxocariasis were associated with increased risk of schizophrenia and/or bipolar disorders (odds ratio = 2.3; 95% CI, 1.7 – 3.2). Finally, toxocariasis and/or toxoplasmosis were associated with an increased risk of the onset of schizophrenia (odds ratio = 2.4; 95% CI, 1.7 – 3.4). Our pooled estimates show that the associations between diseases studied are relatively high in developing and emerging countries. This meta-analysis supports the hypothesis that toxoplasmosis could be the cause of schizophrenia. These findings could prove useful to researchers who want to further explore and understand the associations studied. Keywords: Meta-analysis, association, co-morbidities, mental disorders, neurotropic parasitic diseases.

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“…In contrast, some authors have questioned this association 24,25 . A recent meta-analysis reported a significant association between T. gondii infection as estimated by IgG antibodies and schizophrenia (odds ratio 1.81, P < 0.0001).…”

Section: Discussionmentioning

confidence: 99%

Toxoplasma gondii infection and chronic schizophrenia: is there any association?

Campos-Carli

Vieira

Rocha

et al. 2017

Arch. Clin. Psychiatry (São Paulo)

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Background: Toxoplasma gondii (T. gondii) infection has been identified as a risk factor for schizophrenia. Objectives: Herein, we sought to evaluate the association between T. gondii infection and clinical symptoms and quality of life in patients with schizophrenia. Methods: We conducted a cross-sectional study with 48 patients with chronic schizophrenia and 40 controls. Peripheral blood was drawn, and IgM and IgG anti-T. gondii antibodies were evaluated by Enzyme-Linked Immunosorbent Assay (ELISA). Depressive, positive and negative symptoms were assessed, respectively, by the Calgary Depression Scale (CDS) and the Positive and Negative Syndrome Scale (PANSS). Cognitive performance was assessed in patients by the Brazilian version of the Schizophrenia Cognition Rating Scale (SCoRS-BR). Quality of life was assessed by the Brazilian version of the Quality of Life in Schizophrenia scale (QLS-BR). Results: The prevalence and titers of T. gondii IgM and IgG antibodies did not differ between patients and controls. The positive serology for T. gondii IgG antibodies was not associated with illness symptoms, cognitive performance, depressive symptoms or quality of life. Discussion: Our findings suggest that toxoplasmosis infection is not associated with severity of symptoms, quality of life, cognitive or depressive symptoms in schizophrenia patients.

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Is there any role of latent toxoplasmosis in schizophrenia disease?

Abstract: In the study area with a high prevalence of T. gondii, no association between toxoplasmosis and schizophrenia was detected. These findings showed that toxoplasmosis has no role in the risk of schizophrenia disease.

Cited by 24 publications

References 17 publications

Association of Toxoplasma gondii infection with schizophrenia and its relationship with suicide attempts in these patients

Association of Toxoplasma gondii infection with schizophrenia and its relationship with suicide attempts in these patients

Associations of mental disorders and neurotropic parasitic diseases: a meta-analysis in developing and emerging countries

Toxoplasma gondii infection and chronic schizophrenia: is there any association?

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