Is there association between ABO blood group and the risk factors of unfavorable outcomes of pregnancy?

Seyfizadeh, Nayer; Yousefi, Bahman; Borzoueisileh, Sajad; Majidinia, Maryam; Shanehbandi, Dariush; Jahani, Mohammad Ali

doi:10.3109/14767058.2014.927424

Cited by 16 publications

(16 citation statements)

References 21 publications

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“…In a retrospective cohort of 5320 pregnant women who attended a single tertiary care centre in Thailand, ABO blood group was found to be associated with preeclampsia, but not with GDM . A more recent study of 792 healthy Iranian pregnant women observed that women with blood type AB had higher fasting blood glucose in the second trimester than those with blood type A . In a large prospective cohort of Chinese women with detailed longitudinal documentation of confounders, we observed the women with blood group AB were less likely to have a positive GCT and GDM after adjusting for confounders, suggesting that the association between the ABO blood group and the risk of diabetes and GDM may differ by populations.…”

Section: Discussionmentioning

confidence: 55%

Blood group AB is protective factor for gestational diabetes mellitus: a prospective population‐based study in Tianjin, China

Zhang

Wang

et al. 2015

Diabetes Metabolism Res

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Section: Discussionmentioning

confidence: 55%

Blood group AB is protective factor for gestational diabetes mellitus: a prospective population‐based study in Tianjin, China

Zhang

Wang

et al. 2015

Diabetes Metabolism Res

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“…10 A study consisting of 792 Iranian pregnant women observed that women with blood group AB had higher fasting blood glucose in the second trimester than those with blood group A. 20 But still there are not enough studies in the literature about the association of ABO blood groups with GDM. Because of the increasing prevalence of GDM and DM after GDM, we aimed at investigating any possible relationship between the ABO blood group system and GDM and also transitioning to DM.…”

Section: Discussionmentioning

confidence: 99%

The role of blood groups in the development of diabetes mellitus after gestational diabetes mellitus

Karagöz¹,

Erden²,

Ozer³

et al. 2015

TCRM

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IntroductionGestational diabetes mellitus (GDM) is a common condition that is defined as glucose intolerance of varying degree with onset or first recognition during pregnancy and it affects approximately 5% of all pregnancies all over the world. GDM is not only associated with adverse pregnancy outcomes such as macrosomia, dystocia, birth trauma, and metabolic complications in newborns, but it is also a strong predictor of transitioning to overt DM postpartum. The association of ABO blood groups with DM has been observed before in several epidemiological and genetic studies and resulted with inconsistent findings, but still there are not enough studies in the literature about the association of ABO blood groups with GDM. In this study, we aimed at investigating any possible relationship between the ABO blood group system and GDM and also the transitioning of GDM to overt DM postpartum, in Turkey.Patients and methodsA total of 233 patients with GDM from Kayseri Training and Research Hospital between 2002 and 2012 were included in the study. The cases that have serologically determined blood groups and Rh factor in the hospital records were included in the study, and the patients with unknown blood groups were excluded. Patients were classified according to blood groups (A, B, AB, and O) and Rh status (+/−). GDM was diagnosed based on the glucose cut-points of the International Association of the Diabetes and Pregnancy Society Groups. The distributions of blood groups of the patients with GDM were compared with the distribution of blood groups of 17,314 healthy donors who were admitted to the Turkish Red Crescent Blood Service in our city in 2012.ResultsThere was a significant difference between the patients with GDM and control group in terms of distribution of ABO blood groups. Blood group AB was found to be higher in the patients with GDM compared to the control group (P=0.029). When the patients were compared according to the development of DM, the ratio of group O was higher than others, while the ratio of group B was lower in the group developing DM (P=0.001). There was a significant difference between the groups – GDM patients with or without DM – in terms of distribution of ABO blood groups with Rh factor and the ratio of developing DM is found to be higher in patients with +Rh factor among all the blood groups except for group B (P=0.008).ConclusionIn this study, we found a higher risk of GDM for the patients with blood group AB, which means that we have to be more careful on the follow-up of pregnant women with blood group AB. The patients with GDM of blood group O are under a higher risk of developing DM and also +Rh factor must be considered as another risk factor, so these patients should be closely followed postpartum by the oral glucose tolerance tests. To our knowledge, this is the first analysis that investigates the association between the ABO blood groups and transitioning to DM after GDM.

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“…Unfortunately, the relationship between ABO blood groups and PE which has been observed in many studies for years resulted in conflicting conclusions. 9,10 Adverse pregnancy complications including PE, preterm birth and delivery of low birth weight (LBW) babies represent a major global public health concern. Although these complications generally depend upon the underlying maternal medical conditions such as poorly controlled blood pressure and diabetes, fetal and placental factors can also be responsible from this fetal complication.…”

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confidence: 99%

Effect of maternal ABO blood type on birth weight and preeclampsia

Beyazıt

Pek

Güngör

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: ABO blood group has been recognized as a risk factor for distinct disease states. The association between ABO blood group and adverse pregnancy outcomes has not been extensively studied, especially in relation to birth weight and preeclampsia (PE). The aim of the present study is to determine whether ABO blood group contributes to the adverse pregnancy outcomes including low birth weight and PE.Methods: Medical data including ABO phenotypes were collected from hospital electronic database and retrospectively reviewed. Adverse pregnancy outcomes included PE and low birth weight. Birth week was also noted for each subject.Results: 2177 charts of mothers who had given birth in our hospital were studied. Overall 605 (27.8%) women had type O blood, 1056 (48.5%) had type A blood, 369 (16.9%) had type B blood and 147 (6.8%) had type AB blood. Pregnant women with type B blood group had significantly lower birth weights compared with type O, A and AB. Birth weeks of all groups were found to be similar with no statistically significant difference. A total of 167 mothers were recorded as having PE. No association was observed between PE and ABO blood groups of study participants.Conclusions: Although maternal ABO phenotype is associated with low birth weight, no association was found between blood type and preeclampsia. We postulate that maternal/fetal immune system genes which are directly associated with ABO blood groups could affect pregnant with a resulting birth weight alterations.

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Is there association between ABO blood group and the risk factors of unfavorable outcomes of pregnancy?

Cited by 16 publications

References 21 publications

Blood group AB is protective factor for gestational diabetes mellitus: a prospective population‐based study in Tianjin, China

Blood group AB is protective factor for gestational diabetes mellitus: a prospective population‐based study in Tianjin, China

The role of blood groups in the development of diabetes mellitus after gestational diabetes mellitus

Effect of maternal ABO blood type on birth weight and preeclampsia

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