Is there “brain OAB” and how can we recognize it? International Consultation on Incontinence‐Research Society (ICI‐RS) 2017

Apostolidis, Apostolos; Wagg, Adrian; Rahnama’i, Mohammad Sajjad; Panicker, Jalesh N.; Vrijens, Desiree; Gontard, Alexander von

doi:10.1002/nau.23506

Cited by 19 publications

(12 citation statements)

References 76 publications

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“…The difference in supraspinal activity between OAB patients with or without DO was confirmed by Tadic et al [37], demonstrating that older age and a greater burden of white matter damage in patients with DO are associated with more severe functional urinary impairment. Several reports support the hypothesis that this "white matter disease" could be the anatomical substrate for the brain aetiology of OAB associated with DO, maybe through frontal hypoperfusion [38].…”

Section: Supraspinal Hypothesis: Urgency Originating From the Brain And Brainstemmentioning

confidence: 80%

A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment

Peyronnet¹,

Mironska²,

Chapple³

et al. 2019

European Urology

266

212

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Section: Supraspinal Hypothesis: Urgency Originating From the Brain And Brainstemmentioning

confidence: 80%

A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment

Peyronnet¹,

Mironska²,

Chapple³

et al. 2019

European Urology

266

212

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“…iv) The supraspinal theory: urgency has its origin in the brain and brainstem. With age, deterioration in certain segments of the white matter is possible, leading to urinary disorders (38). v) Detrusor underactivity: secondary to urothelial or suburothelial dysfunction or from detrusor muscle dysfunction, accompanied by detrusor underactivity appears urgency, which has been found in many studies [due in particular to recurrent urinary tract infections (UTIs) that occur through chronic urinary retention] (22,39).…”

Section: Pathophysiology Of Oab Syndromementioning

confidence: 99%

Overactive bladder: A review and update

et al. 2021

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Overactive bladder syndrome is a chronic, disabling condition with physical, psychological and social consequences that significantly affects the quality of life of millions of patients worldwide. The economic impact of this disorder is crucial. Overactive bladder syndrome is a little-known condition, with different manifestations from patient to patient, which causes a great deal of frustration to the medical staff involved. The patient requires a clear explanation and the full support of the attending physician. It is extremely important to establish a correct diagnosis and an effective individualized treatment. The collaboration and understanding of these patients are extremely important aspects. Improving the quality of life in these patients is the main purpose in managing this condition. There are several treatment modalities that may be used progressively, with favorable albeit inconsistent results. This condition remains extremely challenging for specialists and, unfortunately, always one of maximum interest. Contents 1. Introduction 2. Risk factors 3. Pathophysiology of OAB syndrome 4. Evaluation of patients with OAB syndrome 5. Treatment 6. Discussion of the treatment algorithm 7. Conclusions

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“…Although OAB is a widespread problem, the pathophysiology is still unclear. It is likely multifactorial but increasing recent evidence supports a central role of disturbed brain and bladder connection [ 3 , 4 ]. Previously, everything was concentrated only around the bladder.…”

Section: Introductionmentioning

confidence: 99%

An Examination of the Relationship between Urinary Neurotrophin Concentrations and Transcutaneous Electrical Nerve Stimulation (TENS) Used in Pediatric Overactive Bladder Therapy

Bagińska

Sadowska

Korzeniecka‐Kozerska

2021

JCM

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This article aims to explore changes in urinary concentrations of selected neurotrophins in the course of TENS therapy in children with overactive bladder (OAB). A two-group open-label prospective study was conducted. The intervention group comprised 30 children aged between 5 and 12 years old with OAB refractory to conservative therapy. They received 12 weeks of TENS therapy in a home setting. The urinary neurotrophins, NGF, BDNF, NT3, NT4, were measured by ELISA at baseline and at the end of the TENS therapy. Total urinary neurotrophins levels were standardized to mg of creatinine (Cr). We compared the results with the reference group of 30 participants with no symptoms of bladder overactivity. The results revealed that children with OAB both before and after TENS therapy had higher NGF, BDNF, and NT4 concentrations in total and after normalization to Cr than the reference group in contrast to NT3. The response to the therapy expressed as a decrease of urinary neurotrophins after TENS depended on the age and the presenting symptoms. In conclusion, children older than 8 years of age with complaints of daytime incontinence responded better to TENS.

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Is there “brain OAB” and how can we recognize it? International Consultation on Incontinence‐Research Society (ICI‐RS) 2017

Cited by 19 publications

References 76 publications

A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment

A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment

Overactive bladder: A review and update

An Examination of the Relationship between Urinary Neurotrophin Concentrations and Transcutaneous Electrical Nerve Stimulation (TENS) Used in Pediatric Overactive Bladder Therapy

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