We previously reported Keck telescope observations suggesting a smaller value of the fine structure constant, α, at high redshift. New Very Large Telescope (VLT) data, probing a different direction in the universe, shows an inverse evolution; α increases at high redshift. Although the pattern could be due to as yet undetected systematic effects, with the systematics as presently understood the combined dataset fits a spatial dipole, significant at the 4.2σ level, in the direction right ascension 17.5±0.9 hours, declination −58±9 degrees. The independent VLT and Keck samples give consistent dipole directions and amplitudes, as do high and low redshift samples. A search for systematics, using observations duplicated at both telescopes, reveals none so far which emulate this result.PACS numbers: 06.20. Jr, 95.30.Dr, 95.30.Sf, 98.62.Ra, 98.80.Es, 98.80.Jk Quasar spectroscopy as a test of fundamental physics.-The vast light-travel times to distant quasars allow us to probe physics at high redshift. The relative wavenumbers, ω z , of atomic transitions detected at redshift z = λ obs /λ lab − 1, can be compared with laboratory values, ω 0 , via the relationshipwhere the coefficient Q measures the sensitivity of a given transition to a change in α. The variation in both magnitude and sign of Q for different transitions is a significant advantage of the Many Multiplet method [1, 2], helping to combat potential systematics.The first application of this method, 30 measurements of ∆α/α = (α z − α 0 ) /α 0 , indicated a smaller α at high redshift at the 3σ significance level. By 2004 we had made 143 measurements of α covering a wide redshift range, using further data from the Keck telescope obtained by 3 separate groups, supporting our earlier findings, that towards that general direction in the universe at least, α may have been smaller at high redshift, at the 5σ level [3][4][5]. The constant factor at that point was (undesirably) the telescope and spectrograph.New data from the VLT.-We have now analysed a large dataset from a different observatory, the VLT. Full details and searches for systematic errors will be given elsewhere [6,7]. Here we summarize the evidence for spatial variation in α emerging from the combined Keck+VLT samples. Quasar spectra, obtained from the ESO Science Archive, were selected, prioritising primarily by expected signal to noise but with some preference given to higher redshift objects and to objects giving more extensive sky coverage. The ESO midas pipeline was used for the first data reduction step, including wavelength calibration, although enhancements were made to derive a more robust and accurate wavelength solution from an improved selection of thorium-argon calibration lamp emission lines [8]. Echelle spectral orders from several exposures of a given quasar were combined using uves popler [9]. A total of 60 quasar spectra from the VLT have been used for the present work, yielding 153 absorption systems. Absorption systems were identified via a careful visual search of each spectrum, us...