Is There Muscular Weakness in Parkinson's Disease?

Cano‐de‐la‐Cuerda, Roberto; Pérez-de-Heredia, Marta; Miangolarra‐Page, Juan Carlos; Muñoz-Hellín, Elena; Fernández‐de‐las‐Peñas, César

doi:10.1097/phm.0b013e3181a9ed9b

Cited by 103 publications

(90 citation statements)

References 22 publications

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“…Subsequent similar investigations testing the hypothesis of muscle weakness in PD have produced inconsistent results, 19 which may be related to differences in study design and, in light of the findings of the present study, limited statistical power. The differences found in the present cohort were highly significant but evident only for the upper extremities, and of great interest with respect to the initiation of the neurodegenerative processes of PD.…”

Section: Discussioncontrasting

confidence: 42%

Low muscle strength in late adolescence and Parkinson disease later in life

et al. 2015

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Objective: To evaluate maximal isometric muscle force at 18 years of age in relation to Parkinson disease (PD) later in life.Methods: The cohort consisted of 1,317,713 men who had their muscle strength measured during conscription . Associations between participants' muscle strength at conscription and PD diagnoses, also in their parents, were examined using multivariate statistical models. Parkinson disease (PD) is a progressive neurodegenerative disease resulting primarily from the cell death of dopaminergic neurons in the substantia nigra, which produces the cardinal symptoms of bradykinesia, rigidity, and tremor. Results

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Section: Discussioncontrasting

confidence: 42%

Low muscle strength in late adolescence and Parkinson disease later in life

et al. 2015

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“…Although the amount of references available is still restricted, there is a growing number of studies using this device to investigate the strength of different muscle groups in individuals with PD (2,5). In this study, the results of PT assessment in the isokinetic dynamometer showed a significant difference in quadriceps strength in individuals with PD, when compared to subjects without the disease matched for age and gender, corroborating previous studies (5,14).…”

Section: Discussionsupporting

confidence: 79%

“…Recent studies, using sensitive equipment to assess muscle strength, have identified decreased strength in patients with PD when compared to control individuals, who are neurologically healthy (2,5,6). Furthermore, previous studies showed the relationship between muscle weakness and the decline in the basic and essential motor functions regarding the independence of these individuals, pointing out strength training as an important complementary approach (4, 7-10).…”

Section: Introductionmentioning

confidence: 99%

“…The classic symptoms are bradykinesia, tremor, and rigidity (3). However, muscle weakness in PD has gained attention among researchers and it has been pointed out as one of the most important motor symptoms (2,4).…”

Section: Introductionmentioning

confidence: 99%

“…Parkinson's disease (PD) is an idiopathic and progressive disorder which affects 1% to 2% of the world population > 50 years, and its main feature is the severe loss of dopaminergic neurons in the substantia nigra, which is related to somatic motor activity (1,2). The classic symptoms are bradykinesia, tremor, and rigidity (3).…”

Section: Introductionmentioning

confidence: 99%

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Força muscular isocinética dos extensores do joelho em indivíduos com doença de Parkinson

et al. 2013

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INTRODUÇÃO: Apesar do tremor, bradicinesia e rigidez serem os sintomas motores clássicos da doença de Parkinson (DP), a fraqueza muscular também tem sido apontada como um dos mais importantes sintomas motores associados a essa doença, porém, essa condição ainda é pouco estudada e os resultados são inconsistentes. OBJETIVOS: O presente estudo teve o propósito de comparar a força muscular do quadríceps entre indivíduos portadores de DP e indivíduos neurologicamente saudáveis pareados por idade e gênero. Foi comparada também a força muscular do membro mais acometido e menos acometido pela doença. MATERIAIS E MÉTODOS: Participaram deste estudo 26 voluntários, 13 do grupo Parkinson (GP: 64,08 ± 6,87 anos; 73,82 ± 13,03 Kg; 1,66 ± 0,07m;) e 13 do grupo controle (GC: 62,73 ± 6,42 anos; 79,46 ± 11,40 kg; 1,71 ± 0,07 m). Foi mensurado o pico de torque (PT) dos extensores do joelho por meio da dinamometria isocinética, na velocidade de 90º.s-1. Foi utilizado o teste t para comparar as médias intra e entre os grupos (p < 0,05). RESULTADOS: O PT absoluto foi significativamente menor no GP (119,29 ± 40,06 N.m) quando comparado ao GC (145,15 ± 20,05 N.m). Entre os indivíduos com DP, foram encontrados valores significativamente inferiores de força muscular do membro mais acometido quando comparado com o menos acometido (119,29± 40,06 N.m vs. 128,86 ± 35,56 N.m; p < 0,05). CONCLUSÃO: Com base nos resultados, conclui-se que portadores da DP apresentam reduzido PT isocinético dos extensores do joelho, sendo esses achados exacerbados no membro mais acometido pela doença.

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High risk of fall, poor physical function, and low grip strength in men with fracture—the STRAMBO study

Szulc

Feyt

Chapurlat

2015

J cachexia sarcopenia muscle

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BackgroundSeveral studies assessed the association of prevalent fractures with muscle mass, strength, and physical capacity in men. Clinical impact of these associations is not clear, and they could be influenced by confounders. Our aim was to assess the association of the prevalent fractures with muscle strength, physical function, and the risk of subsequent falls in older men after adjustment for muscle mass and potential confounders.MethodsIn a cohort of 890 men aged 50 and older, we assessed appendicular skeletal muscle mass (ASM) by DXA, grip strength, physical function (chair stands, static, and dynamic balance). Relative ASM (RASM) was calculated as ASM / (height)2. Then, 813 men aged 60 and over were followed up prospectively for 5 years and 144 sustained >1 incident falls. All the analyses were adjusted for lifestyle factors, co‐morbidities, and hormones known to influence muscle and physical function.ResultsLow leisure physical activity, very high occupational physical activity, Parkinson's disease, diabetes mellitus, low apparent free testosterone concentration (AFTC), as well as Grade 2 and 3 vertebral fractures and multiple fractures were associated with lower grip strength when adjusted for confounders including upper limb RASM. Low leisure physical activity, very high occupational physical activity, diabetes mellitus, prior stroke, low AFTC and 25‐hydroxycholecalciferol, high C‐reactive protein, vertebral fractures, and non‐vertebral fractures were associated with poor physical function (lowest quintile of the score of tests) when adjusted for confounders including lower limb RASM. Grade 2 and 3 and multiple vertebral fractures were associated with twofold higher risk of multiple falls after adjustment for confounders. Men having multiple fractures had a twofold higher risk of multiple falls after adjusting for confounders. In multivariable models, risk of falls increased proportionally to the increasing severity and number of vertebral fractures as well as to the increasing number of all fractures.ConclusionsIn older men, Grade 2 and 3 vertebral fractures and multiple vertebral and non‐vertebral fractures are associated with lower grip strength, poor physical function, and higher risk of multiple falls after adjustment for multiple confounders. This suggests a real direct association. One fracture can initiate a vicious circle leading to another fracture; thus, patients with fractures need physical therapy regardless of their general health status.

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Is There Muscular Weakness in Parkinson's Disease?

Cited by 103 publications

References 22 publications

Low muscle strength in late adolescence and Parkinson disease later in life

Low muscle strength in late adolescence and Parkinson disease later in life

Força muscular isocinética dos extensores do joelho em indivíduos com doença de Parkinson

High risk of fall, poor physical function, and low grip strength in men with fracture—the STRAMBO study

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