Is there room for allergen immunotherapy for the treatment of atopic dermatitis in the precision medicine era?

Pessina, Benedetta; Giovannini, Mattia; Mori, Francesca; Cara, Giuseppe Di; Novembre, Elio; Chan, Susan; Flohr, Carsten; Toit, George Du

doi:10.3389/fped.2022.1050560

Cited by 1 publication

(2 citation statements)

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“…These two species share high homology and exhibit cross-reactivity [79]. HDMs are the most utilized allergens in AIT for AD [80,81].…”

Section: Methods Employed In the Administration Of Aitmentioning

confidence: 99%

“…The routes of AIT for food allergies are divided into several groups, including subcutaneous immunotherapy (SCIT), sublingual immunotherapy (SLIT), intradermal immunotherapy, and oral immunotherapy (OIT) [82][83][84][85]. The two primary forms of AIT in AD are administered either subcutaneously (SCIT) or sublingually (SLIT) [80,86]. In SCIT, the allergen extract is injected subcutaneously into the lateral or posterior middle portion of the arm [87], whereas SLIT involves the daily administration of antigen drops or tablets under the tongue [88].…”

Section: Methods Employed In the Administration Of Aitmentioning

confidence: 99%

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Advancements in Allergen Immunotherapy for the Treatment of Atopic Dermatitis

Guo,

Wu,

Chen

et al. 2024

IJMS

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Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects individuals of all age groups, manifesting as a spectrum of symptoms varying from mild to severe. Allergen immunotherapy (AIT) involves the administration of allergen extracts and has emerged as a potential treatment strategy for modifying immune responses. Its pathogenesis involves epidermal barrier dysfunction, microbiome imbalance, immune dysregulation, and environmental factors. Existing treatment strategies encompass topical steroids to systemic agents, while AIT is under investigation as a potential immune-modifying alternative. Several studies have shown reductions in the severity scoring of atopic dermatitis (SCORAD) scores, daily rescue medication use, and visual analog scale (VAS) scores following AIT. Biomarker changes include increased IgG4 levels and decreased eosinophil counts. This review provides valuable insights for future research and clinical practice, exploring AIT as a viable option for the management of AD.

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“…These two species share high homology and exhibit cross-reactivity [79]. HDMs are the most utilized allergens in AIT for AD [80,81].…”

Section: Methods Employed In the Administration Of Aitmentioning

confidence: 99%