Is there something wrong in paradise? Christian beliefs and the safety of novel BCR/ABL1 inhibitors

On the safety of low-dose dasatinib in comorbid and non-comorbid patients: what is real-life? (Reply)

“…Another explanation may be underreporting in clinical trials. 7 Notably, in most studies, chest X-rays were only performed routinely until 'month 6', and later only if symptoms were noted, 3,6 whereas in our center, all dasatinib-treated patients had repeated chest X-rays over the entire time period (at least once a year). In other words, most other published data refer only to the frequency of symptomatic pleural effusions.…”

“…There may also be other reasons for under-reporting which we have discussed recently. 7 Finally, we would like to state that we believe that a repeated chest X-ray should indeed be considered in both younger (non-comorbid) and older (often comorbid) patients: in older patients because of the comorbidityassociated risk, and in younger patients because they are potential candidates for stem cell transplantation. For such patients it may be a less favorable scenario if effusion-formation or viral infection/reactivation is overlooked before they are referred.…”