Is There Still a Role for Cyclosporine in the Treatment of Inflammatory Bowel Disease? Pro Argument

Low‐dose oral microemulsion ciclosporin for severe, refractory ulcerative colitis

“…No study has adequately determined whether there is a correlation between ciclosporin serum levels and response rates in steroid‐refractory UC 28 . In the original study with intravenous ciclosporin, dosages were adapted to achieve a broad range of C 0 , from 100 to 400 ng/mL 5 .…”

Acute liver failure as presenting feature of tyrosinemia type 1 in a child with primary HHV‐6 infection

“…4,10 The response rate for the acute intravenous phase has been reported at 56-84%. 11 However, maintenance therapy with oral CYA (either alone or combined with 5-ASA) often fails to prevent early relapse, and colectomy cannot be avoided in 30-70% of cases. 12 Hence, AZA is generally used in preference as maintenance therapy and complications after long-term CYA treatment for ulcerative colitis have yet to be thoroughly evaluated.…”

Rectal malignant lymphoma complicating ulcerative colitis treated with long‐term cyclosporine A

“…Intravenous CYA is now established as an effective and reasonably safe treatment for patients with ulcerative colitis who have failed to respond to treatment with intravenous steroids 4,10 . The response rate for the acute intravenous phase has been reported at 56–84% 11 . However, maintenance therapy with oral CYA (either alone or combined with 5‐ASA) often fails to prevent early relapse, and colectomy cannot be avoided in 30–70% of cases 12 .…”