Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?

Łukawska-Tatarczuk, Magdalena; Zieliński, Jakub; Franek, Edward; Czupryniak, Leszek; Mrozikiewicz-Rakowska, Beata

doi:10.5603/ep.a2022.0018

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…Such results suggest that only a longer duration of thyroid autoimmunity may be related to regional contractile dysfunction of the myocardium, whereas short-term exposure to antithyroid antibodies alone does not have such deleterious effects on cardiac function. Presumably, this is related to systemic inflammation and oxidative stress resulting from thyroid autoimmunity, which also affects the cardiovascular system [22] and a higher tendency of atherosclerosis observed in women with 2 autoimmune diseases [23]. In addition, it may depend on epigenetic factors and immune imbalance, as shown by the recently proven association between sirtuin 1 and IL-27 levels and poorer cardiac function parameters in young women with T1DM and HT [24].…”

Section: Gls -Global Longitudinal Strain T1dm -Type 1 Diabetes Mellitusmentioning

confidence: 99%

Longitudinal strain bull’s eye plot patterns in young women with type 1 diabetes – association of regional cardiac systolic function with thyroid autoimmunity and iron status

Łukawska-Tatarczuk,

Pawlak,

Franek

et al. 2023

Current Topics in Diabetes

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IntroductionAlthough heart failure (HF) in diabetes develops insidiously and affects even young people especially those with type 1 diabetes (T1DM), there is still lack of non-invasive methods to facilitate its early diagnosis. The main aims of this pilot study were to evaluate early left ventricular (LV) segmental changes in young women with T1DM and to determine if they correlate with Hashimoto’s thyroiditis (HT) and iron or ferritin serum levels.Material and methodsThirty women with T1DM (20 of whom had HT) and 30 age-matched controls included in the study underwent medical interview, laboratory tests (serum iron and ferritin levels, glycated hemoglobin, lipid and thyroid profile) and echocardiography using two-dimensional speckle tracking imaging.ResultsWomen with T1DM had significantly reduced longitudinal strain (LS) in the basal and medial anterior and anterolateral segments (p=0.022, p=0.010, respectively) and basal inferior and inferolateral segments than controls (p= 0.035). The significant correlation were found between global and medial anterior and anterolateral LS and HT duration (r=-0.366, p=0.046, r=-0.411, p=0.024, respectively), basal inferolateral LS and iron levels (r=0.404, p=0.027) and medial anteroseptal and inferoseptal LS and ferritin levels (r=-0.498, p=0.005).ConclusionsThe LS bull's eye plot pattern appears to be a non-invasive method for identifying early changes in contractile function, which in women with T1DM are characterized by lesions in basal and medial parts of anterior and anterolateral segments and basal inferior and inferolateral segments. Moreover, part of these changes may be correlated with longer duration of HT and lower serum iron levels.

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Section: Gls -Global Longitudinal Strain T1dm -Type 1 Diabetes Mellitusmentioning

confidence: 99%

Longitudinal strain bull’s eye plot patterns in young women with type 1 diabetes – association of regional cardiac systolic function with thyroid autoimmunity and iron status

Łukawska-Tatarczuk,

Pawlak,

Franek

et al. 2023

Current Topics in Diabetes

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Thyroid peroxidase antibodies were associated with prevalent carotid intima-media thickness in middle-age and older adults: the ELSA-Brasil cohort

Meneghini,

Tebar,

Santos

et al. 2024

J Endocrinol Invest

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Genetic variants and risk of endocrine autoimmunity in relatives of patients with Addison’s disease

Fichna

Małecki

Żurawek

et al. 2023

Endocrine Connections

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Since individuals with Addison’s disease (AD) present considerable co-occurrence of additional autoimmune conditions, clustering of autoimmunity was also predicted among their relatives. The study was aimed to evaluate circulating autoantibodies in first-degree relatives of patients with AD and to correlate them with the established genetic risk factors (PTPN22 rs2476601, CTLA4 rs231775, and BACH2 rs3757247). Antibodies were evaluated using validated commercial assays and genotyping was performed with TaqMan chemistry. The studied cohort comprised 112 female and 75 male relatives. Circulating autoantibodies were found in 69 relatives (36.9%). Thyroid autoantibodies, aTPO and aTg were detectable in 25.1% and 17.1% relatives, respectively. Antibodies to 21-hydroxylase (a21OH) were found 5.8% individuals, and beta cell-specific antibodies to ZnT8, GAD and IA2 – in 7.5%, 8.0% and 2.7%, respectively. The prevalence of a21OH (p=0.0075; OR 7.68; 95% CI 1.903-36.0), aTPO (p<0.0001; OR 3.85; 95%CI 1.873-7.495) and aTg (p<0.0001; OR 7.73; 95% CI 3.112-19.65), as well as aGAD (p=0.0303; OR 3.38; 95% CI 1.180-9.123) and aZnT8 (p=0.032; OR 6.40; 95% CI 1.846-21.91) was significantly increased in carriers of rs2476601 T allele. Moreover, T allele appeared to be risk factor for multiple circulating autoantibody specificities (p=0.0009; OR 5.79; 95% CI 1.962-15.81). None of the studied autoantibodies demonstrated significant association with rs231775 in CTLA4 (p<0.05), and only weak association was detected between BACH2 rs3757247 and circulating aTPO (p=0.0336; OR 2.12; 95%CI 1.019-4.228). In conclusion, first-degree relatives of patients with AD, carriers of the PTPN22 rs2476601 T allele, are at particular risk of developing autoantibodies to the endocrine antigens.

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Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?

Cited by 4 publications

References 34 publications

Longitudinal strain bull’s eye plot patterns in young women with type 1 diabetes – association of regional cardiac systolic function with thyroid autoimmunity and iron status

Longitudinal strain bull’s eye plot patterns in young women with type 1 diabetes – association of regional cardiac systolic function with thyroid autoimmunity and iron status

Thyroid peroxidase antibodies were associated with prevalent carotid intima-media thickness in middle-age and older adults: the ELSA-Brasil cohort

Genetic variants and risk of endocrine autoimmunity in relatives of patients with Addison’s disease

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