Is TNF inhibitor exposure a risk factor for amyotrophic lateral sclerosis?

Bougea, Anastasia

doi:10.1111/fcp.12513

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…Tumor necrosis factor α (TNF-α) and growth factor-beta 1(TGF-β1) were shown to upregulate the expression and activity of P-gp in mice and rats ( Dohgu et al, 2004 ; Bauer et al, 2007 ). As levels of TNF-α and TGF-β1 are increased in ALS patients and mice ( Bougea, 2019 ; Tortelli et al, 2020 ), they are associated with the overexpression of P-gp. Moreover, astrocytes are also suspected to be responsible for the increased expression of P-gp in ALS dependent on ALS genotypes.…”

Section: Alteration Of the Central Nervous System Barriers In Amyotro...mentioning

confidence: 99%

Neuroimmune Crosstalk Between the Peripheral and the Central Immune System in Amyotrophic Lateral Sclerosis

Cai

et al. 2022

Front. Aging Neurosci.

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Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by the degeneration and death of motor neurons. Systemic neuroinflammation contributes to the pathogenesis of ALS. The proinflammatory milieu depends on the continuous crosstalk between the peripheral immune system (PIS) and central immune system (CIS). Central nervous system (CNS) resident immune cells interact with the peripheral immune cells via immune substances. Dysfunctional CNS barriers, including the blood–brain barrier, and blood–spinal cord barrier, accelerate the inflammatory process, leading to a systemic self-destructive cycle. This review focuses on the crosstalk between PIS and CIS in ALS. Firstly, we briefly introduce the cellular compartments of CIS and PIS, respectively, and update some new understanding of changes specifically occurring in ALS. Then, we will review previous studies on the alterations of the CNS barriers, and discuss their crucial role in the crosstalk in ALS. Finally, we will review the moveable compartments of the crosstalk, including cytokines, chemokines, and peripheral immune cells which were found to infiltrate the CNS, highlighting the interaction between PIS and CIS. This review aims to provide new insights into pathogenic mechanisms and innovative therapeutic approaches for ALS.

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Section: Alteration Of the Central Nervous System Barriers In Amyotro...mentioning

confidence: 99%

Neuroimmune Crosstalk Between the Peripheral and the Central Immune System in Amyotrophic Lateral Sclerosis

Cai

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

Is TNF inhibitor exposure a risk factor for amyotrophic lateral sclerosis?

Cited by 1 publication

References 8 publications

Neuroimmune Crosstalk Between the Peripheral and the Central Immune System in Amyotrophic Lateral Sclerosis

Neuroimmune Crosstalk Between the Peripheral and the Central Immune System in Amyotrophic Lateral Sclerosis

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