Is Tobacco Use Associated With Risk of Recurrence and Mortality Among People With TB?

Vidyasagaran, Aishwarya Lakshmi; Readshaw, Anne; Boeckmann, Melanie; Jarde, Alexander; Siddiqui, Faraz; Marshall, Anna-Marie; Akram, Janita; Golub, Jonathan E.; Siddiqi, Kamran; Dogar, Omara

doi:10.1016/j.chest.2023.08.021

Cited by 3 publications

(1 citation statement)

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“…5,6 Morbidity and mortality risks for COVID-19 and tuberculosis can be influenced by smoking and co-morbidities, such as chronic lung disease, diabetes, or liver failure. [7][8][9][10][11] The convergence of these infections constitutes major challenges for public health globally. 12 In 2020, of the 33,148 cases of tuberculosis reported by 29 of 30 EU/EEA countries, 23.2% came from Romania.…”

Section: Introductionmentioning

confidence: 99%

The Impact of COVID-19 on the Tuberculosis Features in a Romanian Pneumology Hospital

Popovici,

Georgescu,

Vasile

et al. 2024

JMDH

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Introduction The COVID-19 pandemic and tuberculosis have epidemiological similarities, being transmitted airborne, favored by direct contact, crowded environments, and vulnerable biological status. Methods We performed a retrospective study of 45 cases of pulmonary tuberculosis associated with COVID-19 (TB+COV+) compared to 45 cases with tuberculous monoinfection (TB+COV-), hospitalized during 2021–2022. Results The demographic characteristics were similar in the two groups, predominating men, a median age of 51 years, living in rural areas, medium level of education and smoking. Common symptoms of the two groups were cough, weight loss, profuse sweating, loss of appetite and hemoptysis, while fever, headache, myo-arthralgias, and digestive symptoms characterized the TB+COV+ forms. The scores of radiological lesions in the TB+COV+ compared to TB+COV- group were significantly higher and persistent, revealing more frequent bilateral extensive lung lesions. There were no significant differences in the biological parameters between the two groups. Mortality was 2.2%, regardless of the association of COVID-19. The frequency of infections with Clostridioides difficile was higher in TB+COV+ cases. Conclusion The co-infection of COVID-19 had a mild impact on the clinical and biological expression of tuberculosis diagnosed in a pandemic context.

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