Is vaspin related to cardio-metabolic status and autonomic function in early stages of glucose intolerance and in metabolic syndrome?

Abstract

BackgroundThis study aims to assess serum vaspin in early stages of glucose intolerance and in the presence of metabolic syndrome (MetS); and to evaluate vaspin correlation to different cardio-metabolic parameters and autonomic tone in these subjects.Methods185 subjects (80 males and 105 females) of mean age 45.8 ± 11.6 years and mean BMI 31.2 ± 6.3 kg/m2, divided into groups according to: glucose tolerance, presence of MetS and cardio-vascular autonomic dysfunction (CAD), were enrolled. Glucose tolerance was studied during OGTT. Anthropometric indices, blood pressure, HbA1c, serum lipids, hsCRP, fasting immunoreactive insulin and serum vaspin were measured. Body composition was estimated by impedance analysis. AGEs were assessed by skin fluorescence. CAD was assessed by ANX-3.0.ResultsThere was no difference in vaspin levels between the groups according to glucose tolerance, presence of MetS, and CAD. Regression analysis revealed independent association between serum vaspin and total body fat in newly diagnosed type 2 diabetes (NDT2D) group, and between serum vaspin and age and total body fat in MetS group. Vaspin negatively correlated with both sympathetic and parasympathetic activity in normal glucose tolerance (NGT) and just with parasympathetic tone in NGT without MetS.ConclusionOur results demonstrate no overt fluctuations in vaspin levels in the early stages of glucose intolerance and in MetS. Total body fat seems to be related to vaspin levels in MetS and NDT2D. Our data show negative correlation between vaspin and autonomic function in NGT, as vaspin is associated with parasympathetic activity even in the absence of MetS.

Elevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults

“… 17 Other studies found that vaspin level increased with aging and was associated with parasympathetic activity even in the absence of metabolic syndrome. 18 In addition, a study found that vaspin cannot be used as an independent marker for the presence of coronary artery disease in the general population. 19 …”

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

“…An interesting observation was demonstrated in the independent research of Ataya et al and Feng et al Considering the duration of diabetes, the negative correlation between time and vaspin concentration was shown [48,59]. Based on these results, Dimova et al suggested that vaspin plays a compensative role in glucose metabolism disorders at the outset of type 2 diabetes (T2DM), and its secretion capacity gradually declines with the increase of the diabetes duration [60]. However, the results of studies conducted on humans are ambiguous.…”

“…There were significant associations of high vaspin levels with glucose and lipid-related metabolic parameters in severely obese patients, as well as post-operative increases in vaspin levels, and correlations of higher pre-and postoperative vaspin concentrations with better metabolic profile [81]. Studies carried out on the Caucasian population demonstrate no overt fluctuations in vaspin levels in the early stages of glucose intolerance and MetS [60]. Opposing results were previously reported by Kim et al The authors demonstrated that serum vaspin concentration was significantly lower in men with MetS than in men without MetS.…”

Understanding the Physiological Links Between Physical Frailty and Cognitive Decline

“…Vaspin is a visceral adipose tissue-derived serine protease inhibitor with insulin-sensitizing effects associated with IR. Circulating vaspin levels increased with aging and were associated with parasympathetic activity even in the absence of metabolic syndrome [124]. Frail older adults showed higher levels of vaspin compared to participants who did not show frailty [125].…”