Is viral coinfection a risk factor for severe lower respiratory tract infection? A retrospective observational study

Eşki, Aykut; Öztürk, Gökçen Kartal; Çiçek, Candan; Gülen, Figen; Demir, Esen

doi:10.1002/ppul.25422

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…In our review, 27 of the included studies reported risk factors for poor outcomes among children with RSV-associated ALRI, 17,22–47 2 studies reported data for influenza, 48,49 and 1 study for SARS-CoV-2. 50 Therefore, we only carried out meta-analysis and subgroup analysis for RSV-associated ALRI.…”

Section: Resultsmentioning

confidence: 99%

Risk Factors for Poor Outcomes in Children Hospitalized With Virus-associated Acute Lower Respiratory Infections: A Systematic Review and Meta-analysis

Trusinska,

Zin,

Sandoval

et al. 2024

Pediatric Infectious Disease Journal

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Background: Acute lower respiratory infection (ALRI) caused by respiratory viruses is among the most common causes of hospitalization and mortality in children. We aimed to identify risk factors for poor outcomes in children <5 years old hospitalized with ALRI caused by respiratory syncytial virus (RSV), influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: We searched Embase, Medline and Global Health databases and included observational studies reporting risk factors for poor outcomes (defined as use of supplemental oxygen, mechanical ventilation, intensive care unit admission, prolonged hospital stay and mortality) published between January 2011 and January 2023. Two authors independently extracted data on study characteristics, outcomes and risk factors. Due to limited data, meta-analyses were only conducted for RSV-ALRI poor outcome risk factors using random effects model when there were at least 3 studies. Results: We included 30 studies. For RSV-related ALRI, significant risk factors based on meta-analysis were: neurological disease [odds ratio (OR): 6.14; 95% confidence intervals (CIs): 2.39–15.77], Down’s syndrome (5.43; 3.02–9.76), chronic lung disease (3.64; 1.31–10.09), immunocompromised status (3.41; 1.85–6.29), prematurity (2.98; 1.93–4.59), congenital heart disease (2.80; 1.84–4.24), underlying disease (2.45; 1.94–3.09), age <2 months (2.29; 1.78–2.94), age <6 months (2.08; 1.81–2.39), viral coinfection (2.01; 1.27–3.19), low birth weight (1.88; 1.19–2.95) and being underweight (1.80; 1.38–2.35). For influenza-related ALRI, chronic conditions and age 6–24 months were identified as risk factors for poor outcomes. Cardiovascular disease, immunosuppression, chronic kidney disease, diabetes and high blood pressure were reported as risk factors for mortality due to SARS-CoV-2 associated ALRI. Conclusions: These findings might contribute to the development of guidelines for prophylaxis and management of ALRI caused by RSV, influenza and SARS-CoV-2.

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Section: Resultsmentioning

confidence: 99%

Risk Factors for Poor Outcomes in Children Hospitalized With Virus-associated Acute Lower Respiratory Infections: A Systematic Review and Meta-analysis

Trusinska,

Zin,

Sandoval

et al. 2024

Pediatric Infectious Disease Journal

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“…La coinfección viral respiratoria aguda requiere una mayor atención y más recursos por parte del personal sanitario, a consecuencia de la sintomatología, el tratamiento y pronóstico se verán afectados dependiendo el patógeno que coinfecta al ser humano. https://doi.org/10.56294/saludcyt2024634 5 Pérez V, et al CONCLUSIONES La presente revisión sistemática proporciona evidencia sobre la presencia de coinfecciones respiratorias virales en pacientes SARS COV-2 positivos, a pesar de que la incidencia de COVID-19 sigue siendo alta, la prevalencia de coinfecciones virales respiratorias es relativamente baja. Las medidas de control de infecciones a nivel mundial pueden haber contribuido a reducir la circulación de virus respiratorios.…”

Section: Discussionunclassified

“…(1) Los virus más prevalentes son el virus de influenza tipo A y B, virus respiratorio sincitial (VRS), rinovirus(HRV), adenovirus y coronavirus, (2,3,4) en niños se han detectado más comúnmente VRS y HRV, seguido de coronavirus. (5,6,7) En Ecuador la enfermedad respiratoria más frecuente es la neumonía, cuyo agente causal primordial es el VRS. (8) Desde el 2019 con la aparición de una nueva variante de coronavirus, COVID-19 (SARS-CoV-2), declarada como pandemia el 11 de marzo del 2020 por la Organización Mundial de la Salud (OMS) por su rápida propagación, ha provocado millones de contagios y muertes en cualquier grupo etario, (9) en Ecuador se registraron 1 067 327 personas confirmadas de coronavirus y 36 034 personas fallecidas.…”

Section: Introductionunclassified

Respiratory viral co-infections: a systematic review on SARS CoV-2, Influenza Virus, Respiratory Syncytial Virus

Pérez,

Recalde-Navarrete

2024

Salud, Ciencia y Tecnología

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Introducción: Las enfermedades respiratorias constituyen una causa importante de morbilidad y mortalidad en la población general pero afecta en mayor medida a adultos mayores, niños y personas inmunocomprometidas, siendo responsables del 80% de estas infecciones los virus. Se ha demostrado según estudios que el virus de la Influenza y virus respiratorio sincitial son los agentes más identificados. Desde el 2019 con inicio de la Pandemia de COVID- 19, la población mundial ha sufrido grandes cambios, con miles de contagios, muertes y perdidas económicas.Métodos: Se llevó a cabo una búsqueda electrónica sistemática de artículos publicados desde el 2018 hasta julio del 2023 en las bases de datos PubMed, Springer Scielo, ELSEVIER, Google Académico. Se eligieron estudios descriptivos, retrospectivo, prospectivo, observacional, meta- análisis, artículos originales, los cuales proporcionaron información estadísticamente, para su búsqueda se utilizó palabras claves como: COVID 19, coinfección, coinfección respiratoria, infección SARS Cov-2, virus de influenza, virus respiratorio sincitial.Resultados: Con la revisión bibliográfica se obtuvieron 552 artículos, de los cuales se escogieron según los criterios de elegibilidad solo 73 excluyendo 52, con un resultado total de 21 artículos científicos. Conclusiones: A pesar de que la incidencia de COVID-19 sigue siendo alta, la prevalencia de coinfecciones virales respiratorias es relativamente baja. Las medidas de control de infecciones a nivel mundial pueden haber contribuido a reducir la circulación de virus respiratorios. Todas estas acciones deberán ser encaminadas en beneficio de la población vulnerable que sean costo efectivas para los sistemas de salud.

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“…28 In another study conducted in Türkiye again, RSV (42.8%), HRV (34.7%), and HBoV (10.0%) were detected in children less than 5 years of age with severe LRTIs. 29 ARDS developed in 28.6% of the patients hospitalized in the PICU with a diagnosis of viral LRTI, and it was the most common complication among the patients hospitalized with viral infection. 30 In our study, the ratio of ARDS development was 9.4% in PCR-positive patients hospitalized in PICU with LRTIs.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and Acute Respiratory Distress Syndrome Propensity of Viral Respiratory Infections in Pediatric Intensive Care Units Prior to the Coronavirus Disease 2019 Pandemic

Evren¹,

Besci²,

Appak

et al. 2023

J Pediatr Infect Dis

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This study aimed to determine the epidemiology and acute respiratory distress syndrome (ARDS) propensity of common respiratory viruses in a tertiary pediatric intensive care unit (PICU) among hospitalized children who were tested for respiratory viruses by polymerase chain reaction (PCR) prior to the coronavirus disease 2019 (COVID-19) pandemic. Respiratory tract samples were collected from patients who were followed up in the Dokuz Eylul University Hospital pediatric intensive care unit between March 2015 and March 2020 and tested for viral pathogens. The results of 269 patients between 1 month and 18 years of age were evaluated retrospectively. In the 5 years preceding the COVID-19 pandemic, 269 patients with a lower respiratory infection were admitted to the PICU. A positive viral PCR result was detected in 160 patients (59.5%). Human rhinovirus was the most common virus (40%), followed by respiratory syncytial virus (26.3%), human bocavirus (10%), and seasonal coronaviruses (10%). Five (33.3%) of the fifteen children who developed ARDS were infected with influenza A/B, while four (26.7%) were infected with human metapneumovirus (hMPV).Although rhinovirus was the most common viral agent in critically ill children, the incidence of ARDS was higher in children aged over 1 year who had influenza or hMPV infection.

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Is viral coinfection a risk factor for severe lower respiratory tract infection? A retrospective observational study

Cited by 7 publications

References 33 publications

Risk Factors for Poor Outcomes in Children Hospitalized With Virus-associated Acute Lower Respiratory Infections: A Systematic Review and Meta-analysis

Risk Factors for Poor Outcomes in Children Hospitalized With Virus-associated Acute Lower Respiratory Infections: A Systematic Review and Meta-analysis

Respiratory viral co-infections: a systematic review on SARS CoV-2, Influenza Virus, Respiratory Syncytial Virus

Epidemiology and Acute Respiratory Distress Syndrome Propensity of Viral Respiratory Infections in Pediatric Intensive Care Units Prior to the Coronavirus Disease 2019 Pandemic

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