Is vitamin C able to prevent premature rupture of membranes?

Aryanti, Citra

doi:10.18203/2320-1770.ijrcog20151600

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…In another pathway, iron deficiency anaemia increases risk of infection and inflammation leading to preterm birth (figure 1) (31,32). Physiologically, vitamin C stimulates the synthesis of collagen fibres of connective tissue extracellular matrix of the amnionchorion and deficiency in vitamin C depletes collagens leading to preterm premature rupture of membranes and preterm labour(figure 1) (24,33,34). Similarly, folate, zinc and pre-pregnancy weight deficiencies increase the risk of restricted foetal growth and birth defects(figure 1) (24,35).…”

Section: Probable Causes Of Preterm Labourmentioning

confidence: 99%

Pathophysiological mechanisms of maternal pro-inflammatory mediators in preterm labour

Adu-Bonsaffoh,

Bayor

2024

Preprint

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Available therapeutic interventions for managing preterm labour have not been consistently successful due to controversies related to its aetiology. However, multiple mechanisms including inflammation play a significant role in the pathogenesis of preterm labour. The extracellular matrix of the amniochorion contains collagen fibres that maintain the tensile strength of the amniochorion, resisting mechanical stress and preventing rejection of the foetal allograft. Expression of pro-inflammatory mediators in the amniochorion triggers production of prostaglandins in the uterus and enzymatic degradation of the resilient extracellular matrix of the foetal membranes by matrix metalloproteinases leading to uterine contractions, cervical remodelling resulting in preterm labour.

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Section: Probable Causes Of Preterm Labourmentioning

confidence: 99%

Pathophysiological mechanisms of maternal pro-inflammatory mediators in preterm labour

Adu-Bonsaffoh,

Bayor

2024

Preprint

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“…Physiologically, vitamin C stimulates the synthesis of collagen fibres of connective tissue extracellular matrix of the amnionchorion and deficiency in vitamin C depletes collagens leading to preterm premature rupture of membranes and preterm labour (Aryanti, 2016;Behrman and Butler, 2007;Lotfabadi, 2013). Similarly, folate, zinc and pre-pregnancy weight deficiencies increase the risk of restricted fetal growth and birth defects (Figure 1) (Behrman and Butler, 2007;Wang et al, 2015).…”

Section: Probable Etiologies Of Preterm Labourmentioning

confidence: 99%

“…Premature rupture of the membranes, hypersensitivity to endogenous catecholamines and fetal hypoxia (Aryanti, 2016;Behrman & Butler, 2007;Lotfabadi, 2013).…”

mentioning

confidence: 99%

Pathophysiological mechanisms of maternal pro-inflammatory mediators in preterm labour

Adu‐Bonsaffoh¹,

Bayor²

2022

J. Physiol. Pathophysiol.

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Available therapeutic interventions for managing preterm labour have not been consistently successful due to controversies related to its etiology. Multiple mechanisms, including inflammation play a significant role in the pathogenesis of preterm labour. The connective tissue extracellular matrix of the amniochorion contains collagen fibres that maintain the tensile strength of the amniochorion, resisting mechanical stress and preventing rejection of the fetal allograft. Expression of pro-inflammatory mediators in the amniochorion triggers production of prostaglandins in the uterus and enzymatic degradation of the resilient extracellular matrix of the fetal membranes by matrix metalloproteinases leading to uterine contractions and cervical remodelling resulting in preterm labour. This review appraises the pathophysiological mechanisms of pro-inflammatory mediators in spontaneous preterm labour and their associations with multi-factorial etiological pathways. The physiological pathways and biological mechanisms of uterine activity during pregnancy and parturition are also discussed. Finally, the review provides an overview of the biological basis of common therapeutic agents for treating preterm labour. In this review, keywords related to pathophysiological mechanisms of maternal proinflammatory mediators in preterm labour and clinical management were used in the literature search from the PubMed and Google Scholar databases. The snowball sampling methodology was further employed to obtain a comprehensive literature search.

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Is vitamin C able to prevent premature rupture of membranes?

Cited by 2 publications

References 22 publications

Pathophysiological mechanisms of maternal pro-inflammatory mediators in preterm labour

Pathophysiological mechanisms of maternal pro-inflammatory mediators in preterm labour

Pathophysiological mechanisms of maternal pro-inflammatory mediators in preterm labour

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