Is vitamin K consumption associated with cardio-metabolic disorders? A systematic review

Rees, Karen; Guraewal, Sanjeet; Wong, Yim Lun; Majanbu, Dauda L.; Mavrodaris, Angelique; Stranges, Saverio; Kandala, Ngianga‐Bakwin; Clarke, Aileen; Franco, Oscar H.

doi:10.1016/j.maturitas.2010.05.006

Cited by 44 publications

(33 citation statements)

References 28 publications

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“…Surprisingly, in the absence of any effect on cell counts and/or cell viability, K2 negatively modulated MGP expression, apparently in contradiction with the statement that in vivo vit K2 is specifically active in modulating the calcification process (Spronk et al, 2003;Beulens et al, 2009), although in most cases positive effects, observed either in vitro and/or in vivo, have to be related to supplementation with menaquinones with longer chains or by the simultaneous presence of other dietary components and/or to healthier lifestyle behavior (Rees et al, 2010). Moreover, it cannot be excluded that these results could be because of a different behavior of fibroblasts compared with smooth muscle cells or, such as those that have been described in other cell types (Goritz et al, 2007;Mertsch et al, 2009), with the association of low MGP expression with low proliferation/migration of cells as an additional effect of vit K2 supplementation.…”

Section: Protein Carboxylation and Mgp Expressioncontrasting

confidence: 68%

Matrix Gla Protein and Alkaline Phosphatase Are Differently Modulated in Human Dermal Fibroblasts from PXE Patients and Controls

Boraldi

Annovi

Vermeer

et al. 2013

Journal of Investigative Dermatology

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Mineralization of elastic fibers in pseudoxanthoma elasticum (PXE) has been associated with low levels of carboxylated matrix gla protein (MGP), most likely as a consequence of reduced vitamin K (vit K) availability. Unexpectedly, vit K supplementation does not exert beneficial effects on soft connective tissue mineralization in the PXE animal model. To understand the effects of vit K supplementation and in the attempt to interfere with pathways leading to the accumulation of calcium and phosphate within PXE-mineralized soft connective tissues, we have conducted in vitro studies on dermal fibroblasts isolated from control subjects and from PXE patients. Cells were cultured in standard conditions and in calcifying medium (CM) in the presence of vit K1 and K2, or levamisole, an alkaline phosphatase (ALP) inhibitor. Control and PXE fibroblasts were characterized by a similar dose-dependent uptake of both vit K1 and vit K2, thus promoting a significant increase of total protein carboxylation in all cell lines. Nevertheless, MGP carboxylation remained much less in PXE fibroblasts. Interestingly, PXE fibroblasts exhibited a significantly higher ALP activity. Consistently, the mineralization process induced in vitro by a long-term culture in CM appeared unaffected by vit K, whereas it was abolished by levamisole.

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Section: Protein Carboxylation and Mgp Expressioncontrasting

confidence: 68%

Matrix Gla Protein and Alkaline Phosphatase Are Differently Modulated in Human Dermal Fibroblasts from PXE Patients and Controls

Boraldi

Annovi

Vermeer

et al. 2013

Journal of Investigative Dermatology

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“…Studies have also shown that vitamin K1 reduces coronary artery calcification in type 2 diabetic patients [15] and in another study vitamin K1 (phylloquinone) was able to reduce the risk of type 2 diabetes [16]. However, the exact role of vitamin K1 in protecting against DN is unclear and this forms the basis for the present study.…”

Section: Introductionmentioning

confidence: 82%

“…As can be seen from Figure 6 15 and the beneficial effects of vitamin K1 are in part due to its ability to inhibit these proinflammatory mediators. IL-10 is an anti-inflammatory cytokine whose levels are important to regulate immune activation in renal cells.…”

Section: Attenuation Of Nf-κb and Inos And Enhancement In Il-10 Levelmentioning

confidence: 93%

Hypoglycemic action of vitamin K1 protects against early-onset diabetic nephropathy in streptozotocin-induced rats

et al. 2015

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“…Similarly, a systematic review showed that there was a significant inverse association between incidence of CHD and intake of menaquinone, but not phylloquinone 30 , while later studies indicate that phylloquinone intake is significantly lower in those at high CV risk 31 . In CKD patients those with higher vitamin K intake had a lower risk of all-cause and CVD mortality 32 .…”

Section: Calcificationmentioning

confidence: 97%

Cardiovascular Calcification and Bone: A Comparison of the Effects of Dietary and Serum Vitamin K and its Dependent Proteins

Nicoll¹,

Howard²,

Henein³

2015

ICFJ

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This review compares the effect of vitamin K on cardiovascular (CV) calcification and bone health and shows that, in principal, the γ-carboxylation of the vitamin K-dependent proteins matrix Gla protein (MGP) and its bone equivalent osteocalcin (OC), generally ensures that hydroxyapatite is kept out of the CV system and is deposited in bone. This is an important finding, since there is currently no reliable treatment for CV calcification.Vitamin K2 (menaquinone) may be more effective in the arteries, while vitamin K1 (phylloquinone) is more active in bone. Nevertheless, there remains considerable uncertainty over the precise scope of the functions of MGP and OC, and their carboxylated and under-carboxylated forms, as well as the newly discovered vitamin K-dependent proteins. Although a diet high in vegetables could deliver adequate phylloquinone, supplementation of menaquinone may be necessary for those at risk of CV calcification. Several animal studies and one human study have demonstrated that arterial calcification could be reduced with vitamin K supplementation and there are further trials in progress. Patients on warfarin are particularly prone to CV calcification but there has been concern that supplementation would either counter warfarin treatment or destabilise INR. In fact, studies suggest that low dose phylloquinone did not increase coagulation and may improve the stability of anticoagulant therapy. Furthermore, use of oral anticoagulants which do not affect vitamin K metabolism, such as ximelagatran, could be used when there is a need for vitamin K supplementation for artery or bone health.

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Is vitamin K consumption associated with cardio-metabolic disorders? A systematic review

Cited by 44 publications

References 28 publications

Matrix Gla Protein and Alkaline Phosphatase Are Differently Modulated in Human Dermal Fibroblasts from PXE Patients and Controls

Matrix Gla Protein and Alkaline Phosphatase Are Differently Modulated in Human Dermal Fibroblasts from PXE Patients and Controls

Hypoglycemic action of vitamin K1 protects against early-onset diabetic nephropathy in streptozotocin-induced rats

Cardiovascular Calcification and Bone: A Comparison of the Effects of Dietary and Serum Vitamin K and its Dependent Proteins

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