Is waist circumference a negative predictor of calcaneal bone mineral density in adult Chinese men with normal weight?

Chen, Ling; Liang, Jixing; Wen, Junping; Huang, Huibin; Li, Liantao; Lin, Wei; Zong, Li; Wang, Nengying; Cai, Liangchun; Tang, Kaka; Chen, Hongjie; Li, Meizhi; Li, Lin; Lu, Jieli; Bi, Yufang; Wang, Weiqing; Chen, Gang

doi:10.21037/atm.2019.04.71

Cited by 12 publications

(7 citation statements)

References 39 publications

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“…As for WC, Joseph et al revealed that it had a negative association with TBMD (Kindler et al, 2019). Additionally, other studies involving 5084 and 4663 participants found that WC was negatively related to BMD (Chen et al, 2019;Hua et al, 2021). These findings are consistent with our results, which showed that WC was negatively associated with TBMD.…”

Section: Discussionsupporting

confidence: 92%

The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study

Wang

Lin²,

Wang³

et al. 2022

Front. Genet.

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Aims: The purpose of this study was to assess the causal effect of abdominal obesity on bone mineral density by two-sample Mendelian randomization (MR).Methods: Abdominal obesity was chosen as exposure in this study. Single nucleotide polymorphisms, extracted from Genome-wide association analysis (GWAS) data, which are closely associated with waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) were used as instrumental variables to perform MR studies. Different site bone mineral density, such as total bone mineral density (TBMD) and forearm bone mineral density (FBMD) were chosen as outcomes. Inverse variance weighted (IVW) was used as the primary method to assess this causality.Results: According to the IVW method (β = −0.177; 95% CI = −0.287, −0.067; p = 1.52 × 10–3), WC had a negative causal relationship with TBMD, besides, with one standard deviation (SD) higher in HC, there was a 0.195 SD decrease in TBMD (95% CI = −0.279, −0.110; p = 6.32 × 10–6), and with an increase of one SD in HC was related to a decrease of 0.312 SD in FBMD analyzed by the IVW.Conclusion: This study showed that abdominal obesity has a negative effect on bone mineral density.

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Section: Discussionsupporting

confidence: 92%

The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study

Wang

Lin²,

Wang³

et al. 2022

Front. Genet.

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“…To date, evidence on the relationship between WC and BMD has remained controversial. In a recent cross-sectional study of 4663 Chinese males, Chen et al ( 9 ) identified WC to be a negative predictor of calcaneal BMD among males ≥40 years of age, with a normal weight to minimize the influence of BMI on the measured relationship between WC and BMD. In a Korean community-based, cross-sectional study including 3042 adults >40 years of age, Kim et al ( 10 ) identified a negative association between WC and BMD after adjusting for age and weight.…”

Section: Discussionmentioning

confidence: 99%

“…Waist circumference (WC), which is an easy-to-determine clinical parameter, has been proposed to assess central obesity in epidemiological surveys ( 7 ), with decrease in WC recommended as a critically important treatment target for reducing adverse health risks ( 8 ). However, studies regarding the relationship between WC and BMD are limited, with controversial findings having been reported ( 9 , 10 , 11 , 12 ). What is known is that bone mass reaches its peak around the age of 30 years, followed by a slow rate decrease starting around the age of 40 years ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Can waist circumference be a predictor of bone mineral density independent of BMI in middle-aged adults?

Hua

Fang

Yao

et al. 2021

Endocrine Connections

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Background: Obesity and osteoporosis are major public health issues globally. The prevalence of these two diseases prompts the need to better understand the relationship between them. Previous studies, however, have yielded controversial findings on this issue. Therefore, our aim in this study was to evaluate the independent association between waist circumference (WC), as a marker of obesity, and the bone mineral density (BMD) of the lumbar spine among middle-aged adults using data from the National Health and Nutrition Examination Survey (NHANES). Methods: Our analysis was based on NHANES data from 2011-2018, including 5,084 adults, 40-59 years of age. A weighted multiple linear regression analysis was used to evaluate the association between WC and lumbar BMD, with smooth curve fitting performed for nonlinearities. Results: After adjusting for body mass index (BMI) and other potential confounders, WC was negatively associated with lumbar BMD in men (β= -2.8, 95%CI: -4.0– -1.6) and premenopausal women (β= -2.6, 95%CI: -4.1– -1.1). On subgroup analysis stratified by BMI, this negative association was more significant in men with a BMI ≥30 kg/m2 (β= -4.1, 95%CI: -6.3– -2.0) and in pre- and postmenopausal women with a BMI <25 kg/m2 (premenopausal women: β= -5.7, 95%CI: -9.4– -2.0; postmenopausal women: β= -5.6, 95%CI: -9.7– -1.6). We further identified an inverted U-shaped relationship among premenopausal women, with a point of inflection at WC of 80 cm. Conclusions: Our study found an inverse relationship between WC and lumbar BMD in middle-aged men with BMI ≥30 kg/m2, and women with BMI <25 kg/m2.

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“…When dealing specifically with central adiposity, the reported results from several observational studies are not consistent. In terms of WC, a cross-sectional study of 4663 Chinese adult men and another cross-sectional study of 3457 Chinese adults found that WC was a negative predictor of BMD [ 19 , 20 ]. This relationship was also found in a Korean study of 8981 individuals [ 21 ] and a small study of 271 overweight adolescents [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

The relationship between central obesity and bone mineral density: a Mendelian randomization study

Jing

Zhang

et al. 2022

Diabetol Metab Syndr

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Background The relationship between obesity and osteoporosis is an important public health issue. The goal of this study was to investigate whether and to what extent central obesity traits affect bone mineral density (BMD). Methods We conducted a two-sample Mendelian randomization analysis. Genomewide significant single nucleotide polymorphisms associated with waist circumference, hip circumference, waist-to-hip ratio, waist circumference adjusted by body mass index (WCadjBMI), hip circumference adjusted by BMI (HCadjBMI) and waist-to-hip ratio adjusted by BMI (WHRadjBMI) were obtained from a large-scale database containing 224,459 samples. The BMD summary dataset was obtained from a UK Biobank database including 265,627 participants. Results The results provided strong evidence that the HCadjBMI trait was causally and negatively associated with BMD (β: − 0.135, 95% CI − 0.216 to − 0.054; P = 0.001), while the WHR trait was causally and positively associated with BMD (β: 0.194, 95% CI 0.062 to 0.325, P = 0.004). No significant effects were observed for other traits on BMD. Conclusions This study indicates variations in the abilities of different central obesity traits to influence BMD. These results should be considered in further studies and public health measures on obesity and osteoporosis prevention strategies.

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Is waist circumference a negative predictor of calcaneal bone mineral density in adult Chinese men with normal weight?

Cited by 12 publications

References 39 publications

The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study

The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study

Can waist circumference be a predictor of bone mineral density independent of BMI in middle-aged adults?

The relationship between central obesity and bone mineral density: a Mendelian randomization study

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