Is β-Catenin a Druggable Target for Cancer Therapy?

Cui, Can; Zhou, Xi‐Lang; Zhang, Guoqing; Qu, Yi; Ke, Xisong

doi:10.1016/j.tibs.2018.06.003

Cited by 123 publications

(117 citation statements)

References 73 publications

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“…We found that AFAP1-AS1 mainly localized in the cytoplasm of cells, indicating that AFAP1-AS1 might perform its function in the cytoplasm. It was reported that β-catenin is an important driver of cancer initiation and progression ( Cui et al, 2018 ). The Wnt/β-catenin signaling pathway has been proved to play critical roles in tumorigenesis and progression in many cancers ( Nusse and Clevers, 2017 ; Tammela et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

AFAP1-AS1 Promotes Epithelial-Mesenchymal Transition and Tumorigenesis Through Wnt/β-Catenin Signaling Pathway in Triple-Negative Breast Cancer

et al. 2018

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Long non-coding RNA (LncRNA) actin filament-associated protein1-antisense RNA 1 (AFAP1-AS1) is overexpressed in various types of cancers and plays an important role in tumor progression and prognosis. This study investigates the role of AFAP1-AS1 in tumor progression in triple-negative breast cancer (TNBC). We found that AFAP1-AS1 was overexpressed in TNBC tissues and cells. Overexpression of LncRNA AFAP1-AS1 was associated with poor prognosis in TNBC patients. Moreover, we demonstrated that upregulation of AFAP1-AS1 promoted cell proliferation and invasion, and inhibited cell apoptosis in vitro, while overexpression of AFAP1-AS1 promoted tumor growth in vivo. Our results also revealed that upregulation of AFAP1-AS1 activated Wnt/β-catenin pathway to promote tumorigenesis and cell invasion by increasing the expression of C-myc and epithelial-mesenchymal transition-related molecules in TNBC. Collectively, AFAP1-AS1 can be an independent prognostic marker and an effective therapeutic target of triple- negative breast cancer.

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Section: Discussionmentioning

confidence: 99%

AFAP1-AS1 Promotes Epithelial-Mesenchymal Transition and Tumorigenesis Through Wnt/β-Catenin Signaling Pathway in Triple-Negative Breast Cancer

et al. 2018

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“…As Wnt signaling is highly conserved and complex, playing an important role in many biological processes, targeting the Wnt signaling pathways carries a risk for significant side effects and toxicities [142,143]. The role of Wnt signaling in tissue homeostasis seems to be a particular source of toxicity, specifically in bone, intestinal, skin, and hair homeostasis, as well as in hematopoiesis [142].…”

Section: Wnt Inhibitor Toxicitiesmentioning

confidence: 99%

Wnt Signaling in Gynecologic Malignancies

McMellen¹,

Woodruff²,

Corr

et al. 2020

IJMS

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Gynecologic malignancies, including ovarian cancer, endometrial cancer, and cervical cancer, affect hundreds of thousands of women worldwide every year. Wnt signaling, specifically Wnt/β-catenin signaling, has been found to play an essential role in many oncogenic processes in gynecologic malignancies, including tumorigenesis, metastasis, recurrence, and chemotherapy resistance. As such, the Wnt/β-catenin signaling pathway has the potential to be a target for effective treatment, improving patient outcomes. In this review, we discuss the evidence supporting the importance of the Wnt signaling pathways in the development, progression, and treatment of gynecologic malignancies.

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“…Some compounds mentioned above have already progressed to phase II oncology trials [108], but some are still under the discovery phase. Presently, no drugs, specifically inhibiting β-catenin, have been approved for the market [109]. Though β-catenin is a potentially druggable target, the possibility of adverse side effects cannot be ignored; it will require more detailed studies to address the key issue of the specificity of β-catenin inhibitor.…”

Section: Clinical Value Of β-Catenin In Cervical Cancer Therapymentioning

confidence: 99%

β-Catenin: oncogenic role and therapeutic target in cervical cancer

Wang

Liu

et al. 2020

Biol Res

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Cervical cancer is a common and fatal malignancy of the female reproductive system. Human papillomavirus (HPV) is the primary causal agent for cervical cancer, but HPV infection alone is insufficient to cause the disease. Actually, most HPV infections are sub-clinical and cleared spontaneously by the host immune system; very few persist and eventually develop into cervical cancer. Therefore, other host or environmental alterations could also contribute to the malignant phenotype. One of the candidate co-factors is the β-catenin protein, a pivotal component of the Wnt/βcatenin signaling pathway. β-Catenin mainly implicates two major cellular activities: cell-cell adhesion and signal transduction. Recent studies have indicated that an imbalance in the structural and signaling properties of β-catenin leads to various cancers, such as cervical cancer. In this review, we will systematically summarize the role of β-catenin in cervical cancer and provide new insights into therapeutic strategies.

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Is β-Catenin a Druggable Target for Cancer Therapy?

Cited by 123 publications

References 73 publications

AFAP1-AS1 Promotes Epithelial-Mesenchymal Transition and Tumorigenesis Through Wnt/β-Catenin Signaling Pathway in Triple-Negative Breast Cancer

AFAP1-AS1 Promotes Epithelial-Mesenchymal Transition and Tumorigenesis Through Wnt/β-Catenin Signaling Pathway in Triple-Negative Breast Cancer

Wnt Signaling in Gynecologic Malignancies

β-Catenin: oncogenic role and therapeutic target in cervical cancer

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