ISAR Consensus Guidelines on Safety and Ethical Practices in In vitro Fertilization Clinics

Malhotra, Jaideep; Malhotra, Keshav; Talwar, Pankaj; Kannan, Priya; Singh, Prabhakar; Kumar, Yogesh; Chimote, Nishad; Joshi, Charudutt; Bawle, Sachin; Agarwal, RB; Agarwal, Saroj; Prakash, Ved; Awasthi, Pooja; Shukla, Sanjay Kumar; Prakash, Ram; Adiga, Satish Kumar

doi:10.4103/0974-1208.330504

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…The Indian Society of Assisted Reproduction came out with the Consensus Guidelines on Safety and Ethical Practices in IVF Clinics in 2021. [ 3 ] The Government of India issued the Assisted Reproductive Technology (Regulation) Act, 2021, and the Surrogacy (Regulation) Act, 2021 to regulate the practice of fertility treatments in the country. [ 4 5 ] Although this guideline and these laws have come out comprehensively on many areas of fertility treatment, there has been little said about empowering the infertile couple by giving them access to proper documentation about their treatment.…”

Section: Introductionmentioning

confidence: 99%

Improving Fertility Treatment Documentation – A Survey

Koshy

2023

Journal of Human Reproductive Sciences

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A BSTRACT Background: Many couples do not have adequate documentation following fertility treatments. Aims: To conduct a survey to understand the information needs of assisted reproductive technology physicians when assessing the reasons affecting treatment outcomes after intrauterine insemination (IUI) and in vitro fertilisation (IVF). Settings and Design: Online survey. Materials and Methods: Anonymous online survey of 14 parameters related to IUI treatment and 21 parameters related to IVF treatment, followed by recommendation of selected parameters for routine documentation. Statistical Analysis Used: Frequency distribution calculation of responses. Results: For IUI, total motile sperm count and post-wash sperm count and motility and for IVF, the quality and number of gametes, embryo number and morphology were the most important parameters. Conclusion: The study creates recommendations for the minimum information desirable in the fertility treatment documentation given to the couple undergoing treatment.

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Section: Introductionmentioning

confidence: 99%

Improving Fertility Treatment Documentation – A Survey

Koshy

2023

Journal of Human Reproductive Sciences

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An expert opinion on rescuing atypically pronucleated human zygotes by molecular genetic fertilization checks in IVF

Capalbo,

Cimadomo,

Coticchio

et al. 2024

Human Reproduction

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IVF laboratories routinely adopt morphological pronuclear assessment at the zygote stage to identify abnormally fertilized embryos deemed unsuitable for clinical use. In essence, this is a pseudo-genetic test for ploidy motivated by the notion that biparental diploidy is required for normal human life and abnormal ploidy will lead to either failed implantation, miscarriage, or significant pregnancy complications, including molar pregnancy and chorionic carcinoma. Here, we review the literature associated with ploidy assessment of human embryos derived from zygotes displaying a pronuclear configuration other than the canonical two, and the related pregnancy outcome following transfer. We highlight that pronuclear assessment, although associated with aberrant ploidy outcomes, has a low specificity in the prediction of abnormal ploidy status in the developing embryo, while embryos deemed abnormally fertilized can yield healthy pregnancies. Therefore, this universal strategy of pronuclear assessment invariably leads to incorrect classification of over 50% of blastocysts derived from atypically pronucleated zygotes, and the systematic disposal of potentially viable embryos in IVF. To overcome this limitation of current practice, we discuss the new preimplantation genetic testing technologies that enable accurate identification of the ploidy status of preimplantation embryos and suggest a progress from morphology-based checks to molecular fertilization check as the new gold standard. This alternative molecular fertilization checking represents a possible non-incremental and controversy-free improvement to live birth rates in IVF as it adds to the pool of viable embryos available for transfer. This is especially important for the purposes of ‘family building’ or for poor-prognosis IVF patients where embryo numbers are often limited.

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Assessment of embryologist sufficiency and associated regional disparities in Japanese assisted reproduction facilities using nationwide survey data (IZANAMI project)

Shirasawa,

Yamada,

Jwa

et al. 2024

J of Obstet and Gynaecol

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AimsThis study aims to comprehensively examine the employment and practices of embryologists in Japan's assisted reproductive technology (ART) laboratories, focusing on the impact of various factors such as ART cycle numbers, add‐ons, and regional differences. Additionally, it seeks to assess the extent to which Japanese ART facilities meet international minimum standards set by the American Society for Reproductive Medicine (ASRM).MethodsA survey was conducted from December 2021 to February 2022 among 621 ART facilities in Japan. The study categorized facilities into five ART cycle groups and compared the number of embryologists across these groups. It also examined the correlation between the number of embryologists, ART cycles, add‐ons, and regional differences. Data were analyzed using linear regression and multiple linear regression analyses.ResultsThe study's findings revealed a significant correlation between the total number of embryologists at each facility and the ART cycles. Notably, there were significant differences in the number of embryologists across all ART cycle categories. Of the 435 facilities, only 44.6% met the ASRM minimum embryologist staffing requirement. The regression analysis further highlighted the significance of ART cycles and preimplantation genetic testing for aneuploidies as factors. Moreover, the number of embryologists stationed at urban facilities was significantly higher than at nonurban facilities, indicating a potential regional disparity.ConclusionIn Japan, it was first found that more than 50% of ART facilities do not have sufficient embryologists in place relative to the number of ART cycles. Furthermore, the add‐ons and regional differences affect the placement of embryologists.

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ISAR Consensus Guidelines on Safety and Ethical Practices in In vitro Fertilization Clinics

Cited by 5 publications

References 10 publications

Improving Fertility Treatment Documentation – A Survey

Improving Fertility Treatment Documentation – A Survey

An expert opinion on rescuing atypically pronucleated human zygotes by molecular genetic fertilization checks in IVF

Assessment of embryologist sufficiency and associated regional disparities in Japanese assisted reproduction facilities using nationwide survey data (IZANAMI project)

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