In inverse synthetic aperture radar (ISAR) imaging of nonuniformly rotating targets, such as highly maneuvering airplanes and ships fluctuating with oceanic waves, azimuth echoes have to be modeled as cubic phase signals (CPSs) after the range migration compensation and the translational-induced phase error correction. For the CPS model, the chirp rate and the quadratic chirp rate, which deteriorate the azimuth focusing quality due to the Doppler frequency shift, need to be estimated with a parameter estimation algorithm. In this paper, by employing the proposed generalized scaled Fourier transform (GSCFT) and the nonuniform fast Fourier transform (NUFFT), a fast parameter estimation algorithm is presented and utilized in the ISAR imaging of the nonuniformly rotating target. Compared to the scaled Fourier transform-based algorithm, advantages of the fast parameter estimation algorithm include the following: 1) the computational cost is lower due to the utilization of the NUFFT, and 2) the GSCFT has a wider applicability in ISAR imaging applications. The CPS model and the algorithm implementation are verified with the real radar data of a ship target. In addition, the cross-term, which plays an important role in correlation algorithms, is analyzed for the fast parameter estimation algorithm. Through simulations of the synthetic data and the real radar data, we verify the effectiveness of the fast parameter estimation algorithm and the corresponding ISAR imaging algorithm.Index Terms-Cubic phase signal (CPS), generalized scaled Fourier transform (GSCFT), inverse synthetic aperture radar (ISAR), nonuniform fast Fourier transform (NUFFT).