ISBT Working Party on Terminology for Red Cell Surface Antigens: Munich Report

Lewis, Marion; Allen, Frederick H.; Anstee, David J.; Bird, G. W. G.; Brodheim, E.; Contreras, M.; Crookston, Marie C.; Dahr, Wolfgang; Engelfriet, C. P.; Giles, Carolyn M.; Issitt, Peter D.; Jøorgensen, J.; Kornstad, L.; Leikola, J.; Lubenko, A.; Marsh, W. L.; Moore, B. P. L.; Morel, Phyllis; Moulds, John J.; Nevanlinna, H. R.; Nordhagen, Rannveig; Rosenfield, R. E.; Sabo, Bernice; Salmon, Ch.; Seidl, S.; Tippett, Patricia; Walker, R. H.; Yasuda, Jinsuke

doi:10.1111/j.1423-0410.1985.tb00788.x

Cited by 43 publications

(18 citation statements)

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“…Partial amino acid sequences for the N-terminal portion of the D polypeptide have been published [residues 1-16, 98; residues 1-21,115; residues 1-32,116, and these sequenc es are identical to that found in that portion of the R6A polypeptide which has so far been sequenced [residues [1][2][3][4][5][6][7][8][9][10][11][12][13]116].…”

Section: Gerbich Antigensmentioning

confidence: 99%

“…Some of these anti gens are found on the red cells of nearly all individuals (high frequency or public antigens), others occur very rare ly (low frequency or private antigens), and still others are polymorphic in one or more ethnic populations. About 150 antigens have been accommodated within 17 blood group systems, whilst the remainder are either genetically distinct from those within the blood group systems, or have yet to be clearly shown to belong to one of these systems [1], Most of the studies which have associated antigens within blood group systems have involved classical genetics; however, in Biochemical analysis of the constituents of the human red cell membrane has occurred in parallel with the genetic studies described above, with the result that the major sur face membrane components, and several of the minor com ponents have been extensively characterised. It is now pos sible to assign many blood group antigens to particular mole cules of the red cell membrane.…”

Section: Introductionmentioning

confidence: 99%

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Blood Group-Active Surface Molecules of the Human Red Blood Cell

Anstee¹

1990

Vox Sanguinis

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The surface of the human red blood cell is dominated by a small number of abundant blood group active proteins. The major proteins are the anion transport protein (band 3) which has AB(H) activity, and Glycophorin A which has MN activity. Band 3 and Glycophorin A are of equal abundance in the normal red cell membrane (approximately 10^6 copies of each) and the two proteins may associate together as a complex. The glucose transporter (band 4.5) has AB(H) activity and there are about 5 x 10^5 copies/red cell. Several polypeptides associate together to form the Rh complex. The major components of this complex (abundance 1-2 x 10^5 copies/red cell) are polypeptides of M(r) 30,000, polypeptides of M(r) 45,000-100,000 and Glycophorin B. The antigens of the Rh blood group system appear to be associated with the polypeptides of M(r) 30,000 and those of M(r) 45,000-100,000 (the latter also express AB(H) activity). Glycophorin B expresses the blood group ‘N’ antigen and the Ss antigens. Glycophorins C and D carry the Gerbich antigens and, together, these polypeptides comprise approximately 10^5 copies/red cell. The complete protein sequence of all the above-mentioned proteins is known, except for the M(r) 30,000 and M(r) 45,000-100,000 polypeptides of the Rh complex for which only partial sequences are available, and Glycophorin D, the sequence of which can be inferred from that of Glycophorin C. Several of the minor blood group active proteins at the red cell surface (abundance <1.2 x 10^4 /red cell) have been the subject of recent studies. The polypeptide expressing Cromer-related blood group antigens has been identified as decay-accelerating factor and that carrying the In^a / In^b antigens as CD44. The protein sequence of both of these proteins has been deduced form nucleotide sequencing. The polypeptides expressing Kell antigens, Lutheran antigens, Fy antigens, and LW antigens have also been identified and partially characterised.

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Section: Gerbich Antigensmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blood Group-Active Surface Molecules of the Human Red Blood Cell

Anstee¹

1990

Vox Sanguinis

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“…Single nucleotide polymorphisms (SNPs) in DNA are correlated with seven different antigens of this system: Doa, Dob, Hy, Joa, Gya, DOYA and DOMR (2-5) . Do antigens are carried on a 47- to 58-kDa glycoprotein attached to the red blood cell membrane via a glycosylphosphatidylinositol (GPI) bond (6) .…”

Section: Introductionmentioning

confidence: 99%

Dombrock genotyping in Brazilian blood donors reveals different regional frequencies of the HY allele

Piassi

Santos

Castilho

et al. 2013

Revista Brasileira De Hematologia E Hemoterapia

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BackgroundDombrock blood group system genotyping has revealed various rearrangements of the Dombrock gene and identified new variant alleles in Brazil (i.e., DO*A-SH, DO*A-WL and DO*B-WL). Because of the high heterogeneity of the Brazilian population, interregional differences are expected during the investigation of Dombrock genotypes. ObjectiveThe present study aims to determine the frequencies of Dombrock genotypes in blood donors from Minas Gerais and compare the frequencies of the HY and JO alleles to those of another population in Brazil. MethodsThe frequencies of the DO alleles in Minas Gerais, a southeastern state of Brazil, were determined from the genotyping of 270 blood donors. Genotyping involved polymerase chain reaction and restriction fragment length polymorphism analysis to identify the 323G>T, 350C>T, 793A>G, and 898C>G mutations, which are related to the HY, JO, DO*A/DO*B, and DO*A-WL/DO*B-WL alleles, respectively. Moreover, the frequencies of rare HY and JO alleles were statistically compared using the chi-square test with data from another Brazilian region. ResultsThe HY allele frequency in Minas Gerais (2.4%) was almost twice that of the JO allele (1.5%). The frequency of the HY allele was significantly higher (p-value = 0.001) than that in another Brazilian population and includes a rare homozygous donor with the Hy- phenotype. In addition, the DO*A-WL and DO*B-WL alleles, which were first identified in Brazil, were found in the state of Minas Gerais. ConclusionsThe data confirm that the frequencies of DO alleles differ between regions in Brazil. The population of Minas Gerais could be targeted in a screening strategy to identify the Hy- phenotype in order to develop a rare blood bank.

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“…from all of the 17 established blood group systems [8] except Colton, Die go, Dombrock, Kell and Yt. The recent addition of F13B (coagulation factor XIII B subunit) to the RCA gene clus ter [9] permits us to use unpublished data from an ongoing comprehensive linkage study of blood group loci in relation to other genetic markers, for differentiation of DAF from CO, DI, DO, KEL and YT.…”

Section: Methodsmentioning

confidence: 99%