2003
DOI: 10.1038/sj.bjc.6600792
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Ischaemia-reperfusion injury in photodynamic therapy-treated mouse tumours

Abstract: Prompted by the observation of ischaemia development during the treatment of tumours by photodynamic therapy (PDT) that is typically followed by a restoration of tumour blood flow and by the indications of secondary superoxide generation after PDT, we aimed in this study to obtain evidence of the induction of ischaemia-reperfusion (I/R) injury in PDT-treated tumours. Using subcutaneous mouse FsaR fibrosarcoma model and Photofrin-based PDT treatment, we have examined the activity of xanthine oxidase (XO, a key … Show more

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Cited by 21 publications
(12 citation statements)
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References 37 publications
(48 reference statements)
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“…2), which confirms the participation of this humoral effector system of innate immunity [40] in the anti-tumor effect of PDT. Other elements, including the activity of nitric oxide [41] and events such as ischemia-reperfusion injury [42] can have important roles in the vascular effects of PDT [4]. Therefore, although the described events in the vasculature of PDT-treated tumors can be prompted by direct photooxidative lesions inflicted in endothelial cells, they can be also effectively initiated by PDT damage produced in perivascular regions of tumor tissue that instigates chemotactic gradients across the vascular endothelium.…”
Section: The Inductive Phase and Vascular Attackmentioning
confidence: 99%
“…2), which confirms the participation of this humoral effector system of innate immunity [40] in the anti-tumor effect of PDT. Other elements, including the activity of nitric oxide [41] and events such as ischemia-reperfusion injury [42] can have important roles in the vascular effects of PDT [4]. Therefore, although the described events in the vasculature of PDT-treated tumors can be prompted by direct photooxidative lesions inflicted in endothelial cells, they can be also effectively initiated by PDT damage produced in perivascular regions of tumor tissue that instigates chemotactic gradients across the vascular endothelium.…”
Section: The Inductive Phase and Vascular Attackmentioning
confidence: 99%
“…When oxygen is reintroduced, it enables XO to induce the formation of xanthine from hypoxanthine, resulting in the release of reactive oxygen species, primarily superoxide anions and hydroxyl radicals. There is growing evidence from experiments with other photosensitisers such as porfimer sodium and ALA that reperfusion ischaemia injury may be important Korbelik et al, 2003).…”
mentioning
confidence: 99%
“…This may reflect the contribution of secondary PDT effects (occurring after photodynamic illumination) to PARP activation in treated tumors. Such effects may, for instance, include the ischemia‐reperfusion insult that we have recently demonstrated in PDT‐treated FsaR tumors (24), which is known to induce PARP activation (38).…”
Section: Discussionmentioning
confidence: 99%