Ischaemia selectivity confers efficacy for suppression of ischaemia-induced arrhythmias in rats

Barrett, Terrance D.; Hayes, Eric; Yong, S. L.; Zolotoy, Alexander; Abraham, Sheela A.; Walker, Michael J.

doi:10.1016/s0014-2999(00)00295-8

Cited by 22 publications

(15 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Naloxone limited did not eliminate the incidence of either VT or VPBs. This pattern was similar to that observed for quinidine used in these studies [29]. Naloxone produced a decrease in blood pressure and heart rate and a prolongation in the P-R and QRS intervals as well as an increase in the RSh amplitude of the EKG suggesting Na channel blockade.…”

Section: Discussionsupporting

confidence: 86%

“…Heart rate was dose-dependently decreased from a control of 359 ± 8 beats/min to 331 ± 9 at this same dose. Quinidine produced the anticipated reduction in both blood pressure and heart rate for the dose administered [29].…”

Section: Hemodynamic and Ekg Effects Of Naloxonementioning

confidence: 96%

“…The BP and ECG were recorded 5 min after infusion and a blood sample (0.25 mL) taken before occlusion. Quinidine (n = 8) was the positive control in this study in order to compare naloxone findings since it blocks Na and K channels in the rat and is antiarrhythmic [29]. Quinidine (2.0 mol/kg) was given as a slow bolus dose (given over 5 min).…”

Section: Coronary Artery Occlusionmentioning

confidence: 99%

See 2 more Smart Citations

Ventricular arrhythmia incidence in the rat is reduced by naloxone

Hayes

Wang

Walker

2015

Pharmacological Research

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 86%

Section: Hemodynamic and Ekg Effects Of Naloxonementioning

confidence: 96%

Section: Coronary Artery Occlusionmentioning

confidence: 99%

See 1 more Smart Citation

Ventricular arrhythmia incidence in the rat is reduced by naloxone

Hayes

Wang

Walker

2015

Pharmacological Research

View full text Add to dashboard Cite

“…Other authors (2,18) have investigated the action of lidocaine after 10 -15 min of coronary occlusion. In such studies, an important finding was that lidocaine mainly prevented Na ϩ loading, thus preventing Ca 2ϩ overload and reducing cardiac damage.…”

Section: Discussionmentioning

confidence: 99%

Exploring the role of pH in modulating the effects of lidocaine in virtual ischemic tissue

Cardona

Trénor

Moltó³

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

Lidocaine is a class I antiarrhytmic drug that blocks Na(+) channels and exists in both neutral and charged forms at a physiological pH. In this work, a mathematical model of pH and the frequency-modulated effects of lidocaine has been developed and incorporated into the Luo-Rudy model of the ventricular action potential. We studied the effects of lidocaine on Na(+) current, maximum upstroke velocity, and conduction velocity and demonstrated that a decrease of these parameters was dependent on pH, frequency, and concentration. We also tested the action of lidocaine under pathological conditions. Specifically, we investigated its effects on conduction block under acute regional ischemia. Our results in one-dimensional fiber simulations showed a reduction of the window of block in the presence of lidocaine, thereby highlighting the role of reduced conduction velocity and safe conduction. This reduction may be related to the antifibrillatory effects of the drug by hampering wavefront fragmentation. In bidimensional acute ischemic tissue, lidocaine increased the vulnerable window for reentry and exerted proarrhythmic effects. In conclusion, the present simulation study used a newly formulated model of lidocaine, which considers pH and frequency modulation, and revealed the mechanisms by which lidocaine facilitates the onset of reentries. The results of this study also help to increase our understanding of the potential antifibrillatory effects of the drug.

show abstract

“…El sistema original se descompone en dos sistemas auxiliares de resolución extremadamente sencilla: Si empleamos la notación L[i] para hacer referencia a los elementos de la diagonal de la matriz L inmediatamente por debajo de la principal (única que tiene elementos significativos) ( (8)(9)(10)(11)(12) Para este sistema empleamos la siguiente notación: U 1 [i] serán los elementos de la diagonal principal de la matriz U(U 1 [1] …”

Section: Descomposición Luunclassified

Modelización matemática y simulación de los efectos de la lidocaína sobre la actividad eléctrica cardíaca en tejido ventricular.

Urrego¹,

Eliana²

View full text Add to dashboard Cite

show abstract

Ischaemia selectivity confers efficacy for suppression of ischaemia-induced arrhythmias in rats

Cited by 22 publications

References 32 publications

Ventricular arrhythmia incidence in the rat is reduced by naloxone

Ventricular arrhythmia incidence in the rat is reduced by naloxone

Exploring the role of pH in modulating the effects of lidocaine in virtual ischemic tissue

Modelización matemática y simulación de los efectos de la lidocaína sobre la actividad eléctrica cardíaca en tejido ventricular.

Contact Info

Product

Resources

About