Ischaemic heart disease incidence and mortality in an extended cohort of Mayak workers first employed in 1948–1982

Abstract

It is the first time the validity of internal radiation dose estimates has been shown to affect the risk of IHD incidence.

Mortality from Circulatory System Diseases among French Uranium Miners: A Nested Case-Control Study

“…It may also be possible that internal exposures influence the pattern of risks we are observing; recent findings in the Mayak cohort suggest a possible link between IHD, cerebrovascular disease and plutonium exposure (34)(35)(36). However, internal exposures in the Mayak cohort are considerably larger than those in other cohorts.…”

“…In published studies of the Russian Federation Mayak nuclear workers, associations between external radiation exposure and circulatory disease have also been reported (34), with significant effects noted for IHD mortality and morbidity (35) and cerebrovascular disease morbidity (36)(37). Mayak relative risk per unit dose estimates were similar to our estimates for circulatory disease mortality and IHD mortality; however, there was little evidence of increased risks of cerebrovascular disease mortality associated with external dose in the Mayak cohort, a significant association only being noted for morbidity.…”

“…However, by their very nature, surrogate measurements for these risk factors are not as good as actual measurements and some residual confounding is likely. Nevertheless, in a recent review on circulatory disease and radiation effects (16), in those studies that had additional information on some of these risk factors (9,(34)(35)(36), ERR/Sv estimates were virtually unchanged when additional adjustment for these factors was made.…”

Circulatory disease in French nuclear fuel cycle workers chronically exposed to uranium: a nested case–control study

“…In fact, EOR/mGy in our study decreased by 50% and became non-significant, compared with the first dosimetry scenario. Although the treatment of less than RL bioassay data differed in this and in the Russian Mayak workers studies,32 both studies found that these could affect results in an important manner. Another important factor influencing dose estimates is uranium solubility.…”

“…Thanks to the AREVA JEM, we were able to integrate uranium solubility type into dose assessment and to provide two sets of doses for individuals with only less than RL bioassay measurements. To date, only a study of Russian Mayak plutonium workers analysed the impact of different internal dosimetry scenarios on risk estimates 32. Although we did not consider specific lipid fractions (high-density lipoprotein and low-density lipoprotein), our study is also among the first to collect data on total cholesterol.…”