Ischaemic heart disease: management of non-ST-elevation acute coronary syndrome

Henderson, Robert A.

doi:10.1016/j.mpmed.2014.06.003

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…Acute Coronary Syndrome (ACS) is the most serious form of coronary artery disease (Hinkle & Cheever 2018). It is estimated that the annual incidence of ACS is 1 in 80 or 1 in 170 in the European general population (Henderson 2014).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Aromatherapy and the Benson Relaxation Technique on the Anxiety of Patients With Acute Coronary Syndrome: Randomized Controlled Trial

Zarghi

Ghezeljeh

2020

JCCNC

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Background: Anxiety is a common symptom in patients with the Acute Coronary Syndrome (ACS), which can threaten their quality of life. This study was done to compare the effects of aromatherapy using lavender and Benson’s relaxation technique on the anxiety of patients with ACS. Methods: In this randomized clinical trial, 96 patients with ACS were selected using consecutive sampling method from two hospitals in an urban area of Iran. The patients were randomly assigned to three groups of aromatherapy (n=32), Benson’s relaxation (n=32), and control (n=32) using the block size of six. The interventions were performed on two consecutive days, once a day for 20 min. Anxiety was measured before and immediately after the intervention using the Spielberger’s Anxiety Inventory. Data were analyzed using the Chi-square test, Fisher’s exact test, one-way Analysis Of Variance (ANOVA), Bonferroni post hoc test, and mixed-model repeated-measures ANOVA with a 3*2*2 design by the SPSS V. 16. Results: There was no statistically significant difference in state and trait anxiety scores between the groups after the intervention on different time points (P> 0.05). The time (P=0.001), group-day interaction (P=0.005), and time (pretest and posttest) and day (P=0.029) effect on state anxiety was statistically significant. The time (P<0.001) and the group-day interaction (P<0.001) effect on trait anxiety was statistically significant. Conclusion: Benson’s relaxation method and lavender aromatherapy did not significantly reduce anxiety in patients with ACS. Considering the anxiety and its complications in patients with ACS and the importance of its management, further studies are needed to determine appropriate care and treatment for these patients and reduce their anxiety.

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Section: Introductionmentioning

confidence: 99%

The Effect of Aromatherapy and the Benson Relaxation Technique on the Anxiety of Patients With Acute Coronary Syndrome: Randomized Controlled Trial

Zarghi

Ghezeljeh

2020

JCCNC

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“…Antiplatelet therapy also should be given, which includes aspirin, P2Y12 inhibitors like clopidogrel, prasugrel, and ticagrelor. Moreover, oral and parenteral anticoagulants (Kumar and Cannon, 2009;Henderson, 2014).…”

Section: Introductionmentioning

confidence: 99%

Clopidogrel efficacy with concomitant drug therapy in patients undergoing percutaneous coronary intervention

Alsalloum¹,

Ibrahim²

2020

Int. j. adv. appl. sci.

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Clopidogrel, as an adjunct to aspirin, has been recommended for patients undergoing percutaneous coronary intervention (PCI) to reduce adverse cardiovascular events. Clopidogrel needs activation via the cytochromes P450 enzymes. Concomitant use of clopidogrel with drugs that utilize the same enzymatic pathway may interfere with its conversion to an active form. This study aims to assess the impact of concomitant drug therapy on clopidogrel efficacy in patients undergoing PCI and to identify the association between the use of those drugs and the risk of future adverse cardiac events. A total of 126 medical records for patients followed at King Fahad Specialist Hospital, and King Saud Hospital in Qassim, Saudi Arabia, were reviewed. Patients were divided into six groups: First group clopidogrel, second to fourth group clopidogrel plus proton pump inhibitors (PPIs)/calcium channel blockers (CCBs)/statins, fifth group clopidogrel with either PPIs, CCBs, statins, and sixth group clopidogrel plus PPIs, CCBs, and statins. Descriptive statistics were performed to detect the correlation between the concomitant drug used and MACEs. Out of the total number, 58 patients had MACEs. The correlation between MACEs and medications used in the groups of clopidogrel with PPIs, statins, or combinations of PPIs with CCBs and statins, or combination of two drugs had a MACEs rate of 12% (P= 0.027), 17.2% (P= 0.0041), 19% (P= 0.0021), 43.1% (P= 0.0001) respectively in comparison to 3.45% in the clopidogrel group. Therefore, concomitant use of clopidogrel with PPIs, statins, or combinations of PPIs with CCBs and statins, or a combination of two drugs is associated with a higher risk of MACEs. This suggests that these medications may attenuate the antiplatelet effect clopidogrel. Prospective randomized studies are needed to provide firm evidence for this interaction.

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Ischaemic heart disease: management of non-ST-elevation acute coronary syndrome

Cited by 2 publications

References 41 publications

The Effect of Aromatherapy and the Benson Relaxation Technique on the Anxiety of Patients With Acute Coronary Syndrome: Randomized Controlled Trial

The Effect of Aromatherapy and the Benson Relaxation Technique on the Anxiety of Patients With Acute Coronary Syndrome: Randomized Controlled Trial

Clopidogrel efficacy with concomitant drug therapy in patients undergoing percutaneous coronary intervention

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