Ischemia in women with angina and normal coronary angiograms

Peix, A. Amalia; García-Barreto, D; Ponce, F.; Cabrera, L.O.; Valiente, Juan; Tornes, F.; Guerrero, Israel; F, Heres; García, Eduardo José Jacinto; Cabalé, Beatriz

doi:10.1016/j.nuclcard.2004.12.014

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Peix et al previously demonstrated that postmenopausal women with normal coronary angiograms diagnosed with microvascular ischemia, frequently developed LV dysfunction during exercise testing. (6) Subjects with either macro- or micro-vascular ischemia may, therefore, demonstrate a similar CPET response, although myocardial perfusion imaging and coronary angiographic findings may show the presence or absence of significant epicardial CAD, respectively. Given the potential advantages of CPET to accurately detect and quantify reversible LV dysfunction in a non-invasive manner without radiation, utilization of this assessment technique in the evaluation and management of suspected microvascular ischemia may be clinically important.…”

Section: Discussionmentioning

confidence: 99%

The utility of cardiopulmonary exercise testing in the assessment of suspected microvascular ischemia

Chaudhry

Arena

Wasserman

et al. 2011

International Journal of Cardiology

View full text Add to dashboard Cite

Evidence demonstrating the potential value of cardiopulmonary exercise testing (CPET) to accurately detect myocardial ischemia secondary to macro-vascular disease is beginning to emerge. Despite distinct mechanisms mediating ischemia in micro-vascular and macrovascular coronary artery disease (CAD), the net physiologic effect of exercise-induced left ventricular (LV) dysfunction is common to both. The abnormal physiologic response to CPET may, therefore, be similar in patients with macro-and micro-vascular ischemia. The following case report describes the CPET abnormalities in a patient with suspected microvascular CAD and the subsequent improvement in LV function following three weeks of medical therapy with the anti-ischemic drug ranolazine.

show abstract

Section: Discussionmentioning

confidence: 99%

The utility of cardiopulmonary exercise testing in the assessment of suspected microvascular ischemia

Chaudhry

Arena

Wasserman

et al. 2011

International Journal of Cardiology

View full text Add to dashboard Cite

show abstract

“…To better detect this condition, new methods of evaluation must be implemented 14. Peix et al have previously demonstrated that postmenopausal women with normal coronary angiograms but diagnosed with microvascular coronary artery disease frequently developed LV dysfunction during exercise testing 15. Subjects with either macro- or microvascular CAD may demonstrate a similar CPET response, although nuclear imaging and cardiac catheterization findings may be quite different.…”

Section: Discussionmentioning

confidence: 99%

Exercise-Induced Myocardial Ischemia Detected by Cardiopulmonary Exercise Testing

Chaudhry

Arena

Wasserman

et al. 2009

The American Journal of Cardiology

View full text Add to dashboard Cite

Cardiopulmonary exercise testing (CPET) is a well-accepted physiologic evaluation technique in patients diagnosed with heart failure and in individuals presenting with unexplained dyspnea on exertion. Several variables obtained during CPET, including oxygen consumption relative to heart rate (VO 2 /HR or O 2 -pulse) and work rate (VO 2 /Watt) provide consistent, quantitative patterns of abnormal physiologic responses to graded exercise when left ventricular dysfunction is caused by myocardial ischemia. This concept paper describes both the methodology and clinical application of CPET associated with myocardial ischemia. Initial evidence indicates left ventricular dysfunction induced by myocardial ischemia may be accurately detected by an abnormal CPET response. CPET testing may complement current non-invasive testing modalities that elicit inducible ischemia. It provides a physiologic quantification of the work rate, heart rate and O 2 uptake at which myocardial ischemia develops. In conclusion, the potential value of adding CPET with gas exchange measurements is likely to be of great value in diagnosing and quantifying both overt and occult myocardial ischemia and its reversibility with treatment.

show abstract

Ischemia in women with angina and normal coronary angiograms

Cited by 2 publications

References 0 publications

The utility of cardiopulmonary exercise testing in the assessment of suspected microvascular ischemia

The utility of cardiopulmonary exercise testing in the assessment of suspected microvascular ischemia

Exercise-Induced Myocardial Ischemia Detected by Cardiopulmonary Exercise Testing

Contact Info

Product

Resources

About