2017
DOI: 10.1080/13510002.2017.1301624
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Ischemia-modified albumin as a marker of vascular dysfunction and subclinical atherosclerosis in β-thalassemia major

Abstract: Background: Ischemia-modified albumin (IMA) is an altered type of serum albumin that forms under conditions of oxidative stress and an independent predictor of major adverse cardiovascular events. Objectives: To measure the levels of IMA in 45 children and adolescents with β-thalassemia major (β-TM) compared with 30 healthy controls and assess its relation to lipid peroxidation, vascular complications and subclinical atherosclerosis. Methods: β-TM patients without symptoms of heart disease were studied focusin… Show more

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Cited by 19 publications
(21 citation statements)
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“…Patients who underwent splenectomy had significantly higher level of CRP and IMA. Our results were in agreement with; Adly et al [16] who reported that thalassemic patients who had splenectomy had significantly higher level of IMA and CRP. Also, they reported that elevation was strongly associated with vascular inflammation, liver dysfunction, hypoxemia, iron overload, left ventricular dysfunction, and increased cardiac output.…”
Section: Discussionsupporting
confidence: 93%
“…Patients who underwent splenectomy had significantly higher level of CRP and IMA. Our results were in agreement with; Adly et al [16] who reported that thalassemic patients who had splenectomy had significantly higher level of IMA and CRP. Also, they reported that elevation was strongly associated with vascular inflammation, liver dysfunction, hypoxemia, iron overload, left ventricular dysfunction, and increased cardiac output.…”
Section: Discussionsupporting
confidence: 93%
“…The Doppler ultrasound studies were performed after an overnight fast and before the administration of morning insulin dose. All of the carotid scans were done by B mode using carotid Doppler ultrasound scanner (Toshiba Ultrasonography machine [Xario], Japan) with a 7 to 10.0‐MHz linear array transducer following a predetermined standardized scanning protocol . All ultrasound scans were performed by an experienced radiologist in vascular Doppler who was unaware of children's clinical details.…”
Section: Methodsmentioning
confidence: 99%
“…Iron overload in thalassemia may cause serious tissue damaging effects due to the generation of oxygen radicals that exceed the antioxidant capacity of body cells 1. Iron is a major oxidant in vivo2 where iron-induced generation of reactive oxygen species (ROS) is responsible for the tissue-damaging effects,3 depletion of endogenous antioxidants, lipid peroxidative damage4 and formation of the major atherogenic factor (oxidized low density lipoprotein) causing atherosclerosis. Lipoperoxides in liver and spleen homogenates are high in conditions of iron overload.…”
Section: Introductionmentioning
confidence: 99%
“…Lipoperoxides in liver and spleen homogenates are high in conditions of iron overload. Noteworthy, oxidative stress in thalassemia patients was reported to impair platelet functions with high plasma oxidative stress indicators, eg, thiobarbituric acid reactive substance (TBAR) levels, that improved with the use of antioxidants 4,5…”
Section: Introductionmentioning
confidence: 99%