Ischemia Modified Albumin Can Predict Necrosis at Incarcerated Hernias

Kadıoğlu, Hüseyin; Ömür, Dilek; Bozkurt, Süleyman; Ferlengez, Ekrem; Memmı, Naim; Ersoy, Yeliz Emine; Cipe, Gokhan; Müslümanoğlu, Mahmut

doi:10.1155/2013/185425

Cited by 19 publications

(14 citation statements)

References 21 publications

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“…This indicates that the decision‐making, including start of emergency operation, should take place within 19 h from the onset of symptoms. This is supported by previous adult studies in which 12–24 h from onset of initial symptom to operation, was noted as the optimal time to avoid bowel resection . Additionally, Barkin reported that severe abdominal pain lasting >6 h in a patient who was previously well usually requires surgery .…”

Section: Discussionsupporting

confidence: 69%

“…This is supported by previous adult studies in which 12-24 h from onset of initial symptom to operation, was noted as the optimal time to avoid bowel resection. [16][17][18] Additionally, Barkin reported that severe abdominal pain lasting >6 h in a patient who was previously well usually requires surgery. 19 Indeed, in the present study, the shortest interval to bowel resection in strangulation was 8 h.…”

Section: Discussionmentioning

confidence: 99%

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Bowel obstruction without history of laparotomy: Clinical analysis of 70 patients

Yoshimaru

Kinoshita

Matsuura

et al. 2016

Pediatrics International

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Malrotation and intussusception are major causes of BO without HL in children, but internal hernia, Meckel's diverticulum and idiopathic volvulus should always be taken into account, particularly because of the preoperative diagnostic difficulty and resulting high rate of intestinal resection. In order to avoid resection of the bowel, surgery should be done within 19 h before bowel ischemic change occurs.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Bowel obstruction without history of laparotomy: Clinical analysis of 70 patients

Yoshimaru

Kinoshita

Matsuura

et al. 2016

Pediatrics International

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“…Ischemia, reperfusion, acidosis and reactive oxygen radicals produced in the process of hypoxia are thought to cause these structural changes . IMA is regarded as a useful biomarker of oxidative stress and as a marker for diseases related to inflammation and vascular endothelial cell dysfunction . IMA is a sensitive biochemical marker for myocardial ischemia, muscle ischemia, pulmonary embolism, metabolic syndrome, hypercholesterolemia, mesenteric ischemia and cerebral ischemia .…”

Section: Discussionmentioning

confidence: 99%

“…40 IMA is regarded as a useful biomarker of oxidative stress and as a marker for diseases related to inflammation and vascular endothelial cell dysfunction. [41][42][43][44] IMA is a sensitive biochemical marker for myocardial ischemia, muscle ischemia, pulmonary embolism, metabolic syndrome, hypercholesterolemia, mesenteric ischemia and cerebral ischemia. 45,46 At the beginning of ischemia, IMA starts to increase and returns into normal values within 24 hours.…”

Section: Immune Complex Accumulation In Small Vessels Activates Inflamentioning

confidence: 99%

Serum neopterin and ischemia modified albumin levels are associated with the disease activity of adult immunoglobulin A vasculitis (Henoch‐Schönlein purpura)

et al. 2019

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Aim The aims of the study are to investigate serum neopterin and ischemia modified albumin (IMA) levels in patients with immunoglobulin A vasculitis (IgAV) and evaluate the association of these markers with disease activity and relapse. Method Thirty‐four consecutive adult patients (24 male and 10 female) admitted to the rheumatology clinic and met the IgAV American College of Rheumatology (ACR) criteria were enrolled in this cross‐sectional study. Demographic and clinical features of IgAV and a control group were recorded into a predefined protocol. Disease activity was categorized as “remission” or “active” according to Birmingham Vasculitis Activity Score (BVAS). BVAS ≥ 1 was accepted as "active". Serum neopterin levels, high‐sensitivity C‐reactive protein (hsCRP) and IMA were evaluated according to BVAS and compared to the healthy control group. Results Serum median (interquartile range) neopterin, IMA levels and hsCRP were higher in the study group than in control group (2.01 [12.5] ng/mL vs 1.77 [1.37] ng/mL, 0.67 [0.2] ng/mL vs. 0.43 [0.17] ng/mL, 5.6 [17.1] mg/L vs. 1.55 [1.6] mg/L, P = .095, P < .001 and P = .002, respectively). When evaluated according to BVAS, IMA and hsCRP levels were significantly higher in the group with active disease (0.77 [0.12] vs 0.61 [0.13] and 14.85 [4.6], P = .009 and P = .03, respectively). Serum neopterin levels were significantly higher in the active group compared to BVAS (18.95 [32.36] vs 1.63 [1.48], P < .001). Conclusion Oxidative stress is important in IgAV pathogenesis. Roles of hsCRP, neopterin and IMA as potential markers of diagnosis and disease activity seem to be worth studying in future studies with larger study groups.

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“…IMA has been tested as a potential marker of bowel ischemia, as detected by cobalt binding assay, with some level of efficiency [ 9 , 10 ]. It is sensitive enough to detect small areas of bowel ischemia during hernia incarceration in animal experiments [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Markers of Perioperative Bowel Complications in Colorectal Surgery Patients

et al. 2015

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Colorectal cancer is a clinical condition whose treatment often involves intestinal resection. Such treatment frequently results in two major gastrointestinal complications after surgery: anastomotic leakage and prolonged ileus. Anastomotic leakage is a serious complication which, more often than not, is diagnosed late; to date, C-reactive protein is the only available diagnostic marker. A monocentric, prospective, open case-control study was performed in patients (n = 117) undergoing colorectal surgery. Intestinal fatty acid binding protein (i-FABP), citrulline, D-lactate, exhaled hydrogen, Escherichia coli genomic DNA, and ischemia modified albumin (IMA) were determined preoperatively, postoperatively, and on the following four consecutive days. Bacterial DNA was not detected in any sample, and i-FABP and D-lactate lacked any distinct potential to detect postoperative bowel complications. Exhaled breath hydrogen content showed unacceptably low sensitivity. However, citrulline turned out to be a specific marker for prolonged ileus on postoperative days 3-4. Using a cut-off value of 20 μmol/L, a sensitivity and specificity of ~75% was achieved on postoperative day 4. IMA was found to be an efficient predictor of anastomosis leak by calculating the difference between preoperative and postoperative values. This test had 100% sensitivity and 80% specificity and 100% negative and 20% positive predictive value.

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Ischemia Modified Albumin Can Predict Necrosis at Incarcerated Hernias

Cited by 19 publications

References 21 publications

Bowel obstruction without history of laparotomy: Clinical analysis of 70 patients

Bowel obstruction without history of laparotomy: Clinical analysis of 70 patients

Serum neopterin and ischemia modified albumin levels are associated with the disease activity of adult immunoglobulin A vasculitis (Henoch‐Schönlein purpura)

Markers of Perioperative Bowel Complications in Colorectal Surgery Patients

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