Ischemia-modified albumin: Crosstalk between fatty acid and cobalt binding

Coverdale, James P. C.; Katundu, Kondwani; Sobczak, Amélie Isabelle Sylvie; Arya, Swati; Blindauer, Claudia A.; Stewart, Alan J.

doi:10.1016/j.plefa.2018.07.014

Cited by 46 publications

(43 citation statements)

References 149 publications

(262 reference statements)

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“…The concentrations of plasma FFAs have been observed to sharply increase in cases of myocardial infarction [ 129 , 130 ], presumably due to reduced consumption by the heart muscle. This will lead to high FFA-loading of serum albumin, and we have proposed [ 33 , 55 , 131 ] that this state of albumin corresponds to the clinically approved biomarker “ischemia-modified albumin” (IMA) [ [132] , [133] , [134] , [135] ]. IMA is quantified by the albumin‑cobalt-binding (ACB) assay, by indirectly measuring the reduced cobalt-binding ability of HSA.…”

Section: Cardiovascular Disease and Haemostasismentioning

confidence: 99%

“…The identification of IMA as HSA with a high FFA load explains essentially all clinical observations, including the lack of specificity: Elevated FFA levels are a hallmark of numerous other conditions and diseases including cancer [ 139 ], diabetes [ 78 ], and stroke [ 140 ]. Invariably, positive ACB assays have been found in these and many other conditions [ 73 , 131 ]. We also note that our hypothesis would predict depressed serum zinc levels for all conditions that elicit positive ACB assays, and this appears to be the case [ 131 ]; some of these conditions are listed in Table 1 .…”

Section: Cardiovascular Disease and Haemostasismentioning

confidence: 99%

“…Invariably, positive ACB assays have been found in these and many other conditions [ 73 , 131 ]. We also note that our hypothesis would predict depressed serum zinc levels for all conditions that elicit positive ACB assays, and this appears to be the case [ 131 ]; some of these conditions are listed in Table 1 .…”

Section: Cardiovascular Disease and Haemostasismentioning

confidence: 99%

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Crosstalk between zinc and free fatty acids in plasma

Coverdale

Khazaipoul

Arya

et al. 2019

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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In mammalian blood plasma, serum albumin acts as a transport protein for free fatty acids, other lipids and hydrophobic molecules including neurodegenerative peptides, and essential metal ions such as zinc to allow their systemic distribution. Importantly, binding of these chemically extremely diverse entities is not independent, but linked allosterically. One particularly intriguing allosteric link exists between free fatty acid and zinc binding. Albumin thus mediates crosstalk between energy status/metabolism and organismal zinc handling. In recognition of the fact that even small changes in extracellular zinc concentration and speciation modulate the function of many cell types, the albumin-mediated impact of free fatty acid concentration on zinc distribution may be significant for both normal physiological processes including energy metabolism, insulin activity, heparin neutralisation, blood coagulation, and zinc signalling, and a range of disease states, including metabolic syndrome, cardiovascular disease, myocardial ischemia, diabetes, and thrombosis.

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Section: Cardiovascular Disease and Haemostasismentioning

confidence: 99%

Section: Cardiovascular Disease and Haemostasismentioning

confidence: 99%

Section: Cardiovascular Disease and Haemostasismentioning

confidence: 99%

See 1 more Smart Citation

Crosstalk between zinc and free fatty acids in plasma

Coverdale

Khazaipoul

Arya

et al. 2019

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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“…İskemi modifiye albümin (IMA), iskemik koşullarda oksijen radikallerinin albüminin N-terminaline hasar vermesiyle oluşan bir varyant proteindir. Klinik çalışmalarda, genellikle iskemik ataktan 6-12 saat içinde yükselmeye başlar ve 24 saat sonra da normal değerlerine düşmeye başlar [28][29][30] [34][35][36][37]. Bu çalışmada, oksidan ve antioksidan sistemin göstergesi olduğu iddia edilen bu parametreler, iki deneysel travma modelinde karşılaştırmalı olarak incelenmiştir.…”

Section: Discussionunclassified

Klip-kompresyon ve ağırlık düşürme modelleriyle oluşturulmuş deneysel omurilik yaralanması modellerinde oksidan-antioksidan parametrelerin analizi

Bal¹,

Hanalıoğlu²,

Apaydın³

et al. 2020

Pamukkale Medical Journal

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Özet Amaç: Deneysel omurilik yaralanmalarında hasarın takibi ve hücrelerin hasara yanıtını değerlendirmek ana unsurlardan biridir. Bu çalışmada iki farklı deneysel omurilik travma modelinde serum ve dokuda oksidanantioksidan maddelerin değişimi incelenerek, bu modellerin spinal travma için kullanılabilirliği araştırılmıştır. Gereç ve yöntem: Çalışmada 3 grupta 6'şar adet Wistar rat kullanıldı. Kontrol grubuna (A grubu) sadece laminektomi yapıldı. Ağırlık grubuna (B grubu) laminektomi ve ağırlık düşürme modeli ile, klip-kompresyon grubuna (C grubu) laminektomi ve klip kompresyon tekniği ile spinal kord hasarı oluşturuldu. Fonksiyonel olarak 12. saat, 1., 3., 5. ve 7. gün Basso-Beattie and Bresnahan (BBB) skorları ile değerlendirildi. Biokimyasal olarak 12. saatte, 1., 5. ve 7. gün alınan kuyruk kanlarında oksidan-antioksidan maddeler incelendi. 7. gün sakrifiye edilen deneklerin omurilik dokularında Total antioksidan kapasite (TAS), Total oksidan kapasite (TOS) ve OSİ (oksidatif stres indeksi) bakıldı. Bulgular: A grubuna göre B ve C grubunda Disülfid (SS)/Total tiol (TT), SS/Native tiol (NT) ve NT/TT oranları 7. günde anlamlı olarak farklı bulunmuştur (p=0,018). Katalaz değerleri arasında 7. günde C grubunda A ve B grubuna göre anlamlı farklılık saptanmış ve C grubunda en belirgin katalaz düşüşü kaydedilmiştir (p=0,012). İMA (iskemi modifiye albümin) erken evrede artsa da hasarın 3. gününden itibaren tekrar azalıp 7. gün normale yakın değerlere gelmiştir. C ile B grubu kıyaslandığında parametrelerin C grubunda daha anlamlı değişiklik gösterdiği görülmüştür. Sonuç: Travma modellerinde oksidatif-antioksidatif markerlar hasarın şiddetini göstermede ve takibinde kullanılabilir. Klip kompresyon yöntemi, serumda oksidatif stres parametrelerini ölçmek ve omurilik travmasını değerlendirmek için daha başarılı bir deneysel omurilik yaralanması yöntemidir.

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“…178 Thus, FFA binding alters conformational changes and inhibits the metal ion binding to albumin. 179,180 Chronic diseases associated with ''glycated/ oxidized'' albumin, oxidative stress generates ''irreversible'' oxidation-modified albumin secondary to oxidation adducts on albumin. 176 Henceforth, the use of both standard ACB assay and ELISA tests for determining IMA levels is ideal.…”

Section: St2mentioning

confidence: 99%

Novel Invasive and Noninvasive Cardiac-Specific Biomarkers in Obesity and Cardiovascular Diseases

Parsanathan

Jain

2020

Metabolic Syndrome and Related Disorders

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Cardiovascular disease (CVD) is the leading cause of fatality and disability worldwide regardless of gender. Obesity has reached epidemic proportions in population across different regions. According to epidemiological studies, CVD risk markers in childhood obesity are one of the significant risk factors for adulthood CVD, but have received disproportionally little attention. This review has examined the evidence for the presence of traditional cardiac biomarkers (nonspecific; lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, creatine kinase, myoglobulin, glycogen phosphorylase isoenzyme BB, myosin light chains, ST2, and ischemia-modified albumin) and novel emerging cardiac-specific biomarkers (cardiac troponins, natriuretic peptides, heart-type fatty acid-binding protein, and miRNAs). Besides, noninvasive anatomical and electrophysiological markers (carotid intima-media thickness, coronary artery calcification, and heart rate variability) in CVDs and obesity are also discussed. Modifiable and nonmodifiable risk factors associated with metabolic syndrome in the progression of CVD, such as obesity, diabetes, hypertension, dyslipidemia, oxidative stress, inflammation, and adipocytokines are also outlined. These underlying prognostic risk factors predict the onset of future microvascular and macrovascular complications. The understanding of invasive and noninvasive cardiac-specific biomarkers and the risk factors may yield valuable insights into the pathophysiology and prevention of CVD in a high-risk obese population at an early stage.

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Ischemia-modified albumin: Crosstalk between fatty acid and cobalt binding

Cited by 46 publications

References 149 publications

Crosstalk between zinc and free fatty acids in plasma

Crosstalk between zinc and free fatty acids in plasma

Klip-kompresyon ve ağırlık düşürme modelleriyle oluşturulmuş deneysel omurilik yaralanması modellerinde oksidan-antioksidan parametrelerin analizi

Novel Invasive and Noninvasive Cardiac-Specific Biomarkers in Obesity and Cardiovascular Diseases

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