Ischemia-modified albumin in patients with hyperthyroidism and hypothyroidism

Varikasuvu, Seshadri Reddy; Pasupuleti, Pullaiah; Rao, Pragna; Garg, Renu; Haribabu, Aennampalli

doi:10.1016/j.ejim.2013.10.003

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…Human serum albumin is the primary binder of free fatty acids (FFAs) that have a potential role in the formation of IMA. Therefore, variations in the concentration of FFA would affect IMA values (27). Although Ersoy et al suggested that they did not find any significant difference between euthyroid, subclinical hypothyroid, and overt hypothyroid groups, IMA levels tended to decrease in hypothyroid group compared to euthyroid group.…”

Section: Discussionmentioning

confidence: 96%

Evaluation of the Relationship Between Ischemia‐Modified Albumin Levels and Thyroid Hormone Levels

Oncel

Kiyici

Onen³

2014

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 96%

Evaluation of the Relationship Between Ischemia‐Modified Albumin Levels and Thyroid Hormone Levels

Oncel

Kiyici

Onen³

2014

Clinical Laboratory Analysis

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“…Moreover, in a previous report on IMA in DR, the IMA values have not been corrected for serum albumin changes. 11 Because of the dependence of IMA values on albumin level, it would be important to report albumin levels and IMA values corrected for albumin interference as previously suggested by us 28,29 and others. 26 Therefore, for the first time, we report significantly increased cIMA values in both patient groups than in controls and there were higher levels of cIMA in DR patients than in the DM group.…”

Section: Discussionmentioning

confidence: 99%

Associations of FPG, A1C and disease duration with protein markers of oxidative damage and antioxidative defense in type 2 diabetes and diabetic retinopathy

Reddy

Sethi

Gupta

et al. 2015

Eye

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Purpose To investigate the role of protein oxidative damage and antioxidant defense in relationship to hyperglycemia measured as fasting plasma glucose (FPG), glycated hemoglobin (A1C), and duration of disease in type 2 diabetes mellitus (DM) and diabetic retinopathy (DR). Methods This study recruited 23 nondiabetic subjects, 16 DM patients without any complications and 18 DR patients. The serum ischemia modified albumin (IMA) and glutathione (GSH) levels were measured. The IMA results were corrected for serum albumin. Between-group differences were studied by analysis of variance and betweenvariable associations were studied by Spearman's and partial correlations. Results IMA and cIMA values were elevated, whereas GSH was decreased in both patient groups vs controls (Po0.05), and the increase in IMA formation is not related to serum albumin changes. DR patients have much severe oxidative stress (OS) status with high IMA and cIMA, and low GSH than in the DM group (Po0.05). Both FPG and A1C levels were positively associated with IMA in DM group, while in the DR group, duration of disease too had a positive association with IMA. The antioxidant GSH had negative correlations with FPG (r = − 0.52, P = 0.02) and IMA (r = − 0.49, P = 0.03) in the DR group. Partial correlation analyses predicted mutual or independent associations among parameters. Conclusions Severe OS in DR has been associated with increased FPG, A1C, and disease duration. Both hyperglycemia and elevated oxidative damage detected as IMA are collectively associated with depleted GSH status. Our study unravels the need for monitoring of OS in addition to standard glycemic management in DR.

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“…In circumstances where OS increases, the extent of albumin structure modification also increases. Recently, IMA has been widely accepted as a marker of OS in many pathological conditions including AA (26)(27)(28). In their study, Dumlu et al (29) also observed increased IMA levels in the AG than in the CG.…”

Section: The Demographic Results Of Groupsmentioning

confidence: 87%

Tiyol / Disülfit dengesinin değerlendirilmesi çocuklarda apandisitin ayırıcı tanısında yardımcı olabilir mi?

Demir¹,

Günal²,

Özmen³

et al. 2020

Turkish Journal of Pediatric Disease

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Objective: We aimed to investigate the potential of assessing thiol/disulfide homeostasis as novel oxidative stress markers to improve the challenging diagnosis of acute appendicitis in children. Material and Methods: A total of 60 pediatric patients (0-18 years) were enrolled in the study, 30 of which were in the control group and 30 in the acute appendicitis group. Native thiol, total thiol, dynamic disulfide, dynamic thiol, ischemia modified albümin, albumin, White blood cell, hemoglobin, hematocrit, and platelet counts of both groups were measured. The results of both groups were compared using the SPSS (Statistical Package for Social Sciences) version 17 (Chicago, USA) program. For all variables, p <0.05 was considered significant. Results: Total thiol (p<0.001), native thiol (p<0.001), and albümin (p<0.001) levels were significantly decreased while dynamic disulfide, dynamic thiol (p=0.003), and ischemia modified albümin (p<0.001) levels those indicating oxidant side were increased in acute appendicitis group compared to control. White blood cell counts in acute appendicitis group were higher (p<0.001), and platelet counts were lower (p=0.03) than the control group. Conclusion: In the differential diagnosis of acute appendicitis, especially in case that are difficult to diagnose, besides a physical examination, imaging, and current laboratory tests, quantification of thiol/disulfide homeostasis may be helpful in diagnosing. In addition, evaluating albumin and IMA levels may increase the specificity of the test. This test can be more helpful in cases diagnosis is difficult such as children small in their ages and mental retardation.

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Ischemia-modified albumin in patients with hyperthyroidism and hypothyroidism

Cited by 6 publications

References 12 publications

Evaluation of the Relationship Between Ischemia‐Modified Albumin Levels and Thyroid Hormone Levels

Evaluation of the Relationship Between Ischemia‐Modified Albumin Levels and Thyroid Hormone Levels

Associations of FPG, A1C and disease duration with protein markers of oxidative damage and antioxidative defense in type 2 diabetes and diabetic retinopathy

Tiyol / Disülfit dengesinin değerlendirilmesi çocuklarda apandisitin ayırıcı tanısında yardımcı olabilir mi?

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