Ischemia‐modified albumin in preterm infants born to mothers with pre‐eclampsia

Özdemir, Özmert Ma; Özdemir, Emine Zahide; Enli, Yaşar; Öztekin, Özer; Ergin, Hacer

doi:10.1111/ped.13563

Cited by 7 publications

(8 citation statements)

References 36 publications

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“…As serum IMA levels are indicative of ischemia, IMA levels should be increased in IUGR infants. However conflicting results are reported about the concentration of cord blood IMA in IUGR infants (17)(18)(19). In this study, we found that cord blood IMA levels were significantly higher in SGA infants than AGA infants.…”

Section: Discussioncontrasting

confidence: 51%

“…Furthermore, elevated maternal serum IMA levels have been recently demonstrated in early normal pregnancy, supporting the hypothesis that pregnancy is always associated with immense stress in order to accommodate the increasing demands of the developing fetus (16). Then, OS has been reported to be notable in the development of PE and IMA has been reported as a novel predictive biomarkker for PE to reflect the OS in the pathogenesis (8) and some studies have demonstrated the correlation of serum IMA with severity of preeclampsia (7,17). In our study increased cord blood IMA levels of infants of preeclamptic mothers are indicative of higher OS status.…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Preeklamptik annelerin bebeklerinde kordon kanı iskemi modifiye albümin düzeyleri ve ortalama trombosit hacminin değerlendirilmesi

Kavurt

Iyigün²,

Demirel

et al. 2021

Türk Kadın Sağlığı Ve Neonatoloji Dergisi

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Aim: Oxidative stress (OS) is a known cause of placental dysfunction, thus may be causally related to preeclampsia and small for gestational age infant (SGA). We aimed to investigate cord blood ischemia-modified albumin (IMA) and mean platelet volüme (MPV) levels in neonates born to mothers with preeclampsia and correlate the determined levels with beeing SGA. Material and Method:A prospective controlled study was conducted. Fifty infants of mothers with preeclampsia, 40 healthy neonates of healthy mothers were included. Cord blood IMA and MPV levels were measured in infants of mothers with preeclampsia. The role of cord blood IMA levels to predict beeing SGA was also investigated. Results:Cord blood IMA and MPV levels of infants of preeclamptic mothers were significantly higher compared to controls. Serum IMA levels were significantly higher in SGA infants compared to appropirate for gestational age (AGA) infants (p=0.018), however MPV levels were similar in both groups (p=0.735). Conclusion:According to this study cord blood IMA and MPV levels may be considered useful as a simple measure of OS status in infants of mothers with preeclampsia. However, further studies with larger samples will be necessary to determine usefulness of these markers in clinical practice.

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 90%

Preeklamptik annelerin bebeklerinde kordon kanı iskemi modifiye albümin düzeyleri ve ortalama trombosit hacminin değerlendirilmesi

Kavurt

Iyigün²,

Demirel

et al. 2021

Türk Kadın Sağlığı Ve Neonatoloji Dergisi

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“…It was demonstrated that the drop in albumin in plasma and the rise in IMA occurred in ischemia pregnancies as a result of inflammation and endothelial cell activity being activated. Similarly, Özdemir et al found that cord blood IMA was significantly higher and albumin was markedly lower (18) . Van Rijn et al explained this by impaired placental circulation, which is related to restricted fetal growth (19) .…”

Section: Discussionmentioning

confidence: 86%

Ischemia-Modified Albumin in Cord Blood of Preterm Infants: A Novel Indicator for Intrauterine Growth Restriction- A Prospective Case Control Study.

El-Raggal¹,

Abdelghani²,

Nawara³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Ischemia modified albumin (IMA) rises promptly after an ischemic event and stays elevated for several hours. However, a knowledge gap still exists in terms of the association between intrauterine growth restriction (IUGR) and IMA levels. Objective: The purpose of this study is to ascertain any potential relationships between cord blood IMA levels and IUGR in preterm newborns with or without complex gestations, Methods: A prospective case-control study included 80 mothers of preterm neonates (<37 gestational weeks). Based on antenatal ultrasound findings, eligible women were divided into two groups: case group including the women diagnosed antenatally with IUGR, and control group including women with normal fetal development. The analysis and quantification of the IMA levels was done using a double-antibody sandwich ELISA kit Results: The albumin level was significantly lower in the case group compared to the control group (3.18 ± 0.28 versus 3.88 ± 0.49; p <0.001), while the IMA level was significantly higher in the case group compared to the other group (145 (97.5 -210) versus 40 (25-90); p <0.001). At a cut-off point of ≤ 3.4, the albumin had an AUC of 0.993, a sensitivity of 95%, and a specificity of 87.5% for differentiating IUGR. While the cut-off point of IMA of >50 had an AUC of 0.850, a sensitivity of 92.5%, and a specificity of 67.5% for prediction of IUGR. Conclusion:The levels of IMA and albumin in the cord blood have a strong correlation with the IUGR.

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“…Also, some clinical studies have recently indicated elevated levels of IMA in neonatal sepsis, preterm infants born to mothers with preeclampsia, preterm infants with respiratory distress syndrome, infants of diabetic mother, and ischemic conditions such as necrotizing enterocolitis in newborns. [7][8][9] This study aimed to assess the value of IMA as a diagnostic marker for neonatal hypoxic-ischemic encephalopathy (HIE).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies about IMA levels and hypoxia have been published ( Table 1 ). Also, some clinical studies have recently indicated elevated levels of IMA in neonatal sepsis, preterm infants born to mothers with preeclampsia, preterm infants with respiratory distress syndrome, infants of diabetic mother, and ischemic conditions such as necrotizing enterocolitis in newborns [ 7 - 9 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the role of ischemia modified albumin in neonatal hypoxic-ischemic encephalopathy

et al. 2020

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Background: Birth asphyxia is a leading cause of neonatal mortality. Ischemia-modified albumin (IMA) levels may have a predictive role in the identification and prevention of hypoxic disorders, as they increase in cases of ischemia of the liver, heart, brain, bowel, and kidney.Purpose: This study aimed to assess the value of IMA levels as a diagnostic marker for neonatal hypoxic-ischemic encephalopathy (HIE).Methods: Sixty newborns who fulfilled 3 or more of the clinical and biochemical criteria and developed HIE as defined by Levene staging were included in our study as the asphyxia group. Neonates with congenital malformation, systemic infection, intrauterine growth retardation, low-birth weight, cardiac or hemolytic disease, family history of neurological diseases, congenital or perinatal infections, preeclampsia, diabetes, and renal diseases were excluded from the study. Sixty healthy neonates matched for gestational age and with no maternal history of illness, established respiration at birth, and an Apgar score ≥7 at 1 and 5 minutes were included as the control group. IMA was determined by double-antibody enzymelinked immunosorbent assay of a cord blood sample collected within 30 minutes after birth.Results: Cord blood IMA levels were higher in asphyxiated newborns than in controls (250.83±36.07 pmol/mL vs. 120.24±38.9 pmol/mL). Comparison of IMA levels by HIE stage revealed a highly significant difference among them (207.3±26.65, 259.28±11.68, 294.99±4.41 pmol/mL for mild, moderate, and severe, respectively). At a cutoff of 197.6 pmol/mL, the sensitivity was 84.5%, specificity was 86%, positive predictive value was 82.8%, negative predictive value was 88.3%, and area under the curve was 0.963 (<i>P</i><0.001).Conclusion: IMA levels can be a reliable marker for the early diagnosis of neonatal HIE and can be a predictor of injury severity.

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Ischemia‐modified albumin in preterm infants born to mothers with pre‐eclampsia

Abstract: Serum IMA in addition to the prevalence of SGA were significantly increased in the PE group. Cord blood IMA, therefore, might be a predictive biomarker for SGA in PE pregnancies.

Cited by 7 publications

References 36 publications

Preeklamptik annelerin bebeklerinde kordon kanı iskemi modifiye albümin düzeyleri ve ortalama trombosit hacminin değerlendirilmesi

Preeklamptik annelerin bebeklerinde kordon kanı iskemi modifiye albümin düzeyleri ve ortalama trombosit hacminin değerlendirilmesi

Ischemia-Modified Albumin in Cord Blood of Preterm Infants: A Novel Indicator for Intrauterine Growth Restriction- A Prospective Case Control Study.

Evaluation of the role of ischemia modified albumin in neonatal hypoxic-ischemic encephalopathy

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