Ischemia modified albumin is an indicator of oxidative stress in multiple sclerosis

Aydın, Özgür; Elli̇dağ, Hamit Yaşar; Eren, Esin; Kurtuluş, Fatma; Yaman, Aylın; Yılmaz, Necat

doi:10.11613/bm.2014.041

Cited by 33 publications

(25 citation statements)

References 21 publications

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“…IMA levels have been reported to increase in diseases capable of causing acute or chronic hypoxia and oxidative stress 17 . IMA levels also increase in diseases that oxidative stress is implicated in etiopathogenesis, such as psoriasis, diabetes mellitus, multiple sclerosis, some cancers, polycystic ovary syndrome and b-thalassemia major 10,[18][19][20][21][22] . Our review of the literature revealed a limited number of studies of IMA and dermatological diseases.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of ischemia-modified albumin levels in acne vulgaris patients

Gürel¹,

Karadöl²,

Bal³

et al. 2019

TURKDERM

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Background and Design: Acne vulgaris (AV) is one of the most common dermatological diseases seen in late childhood and adolescence. The purpose of this study is to evaluate ischemia-modified albumin (IMA) levels in AV, a cutaneous inflammatory disease. Materials and Methods: Seventy-four patients between 15 and 30 years of age with clinically diagnosed AV, and 60 healthy age and sex matched controls without AV were enrolled in the study. Serum IMA levels were measured using the albumin cobalt binding test. The capacity of cobalt binding to albumin decreases under ischemic conditions. Patient serum is mixed with cobalt chloride and incubated for 5 minutes, during which the cobalt is allowed to bind to the albumin. This is mixed with dithiothreitol (DTT) following incubation, and result in a colored complex with cobalt unbound to albumin for DTT. The resulting colored complex is measured spectrophotometrically at a wavelength of 500 nm. Results: The mean age of the AV group with AV was 18.54 (±3.40), and the mean age of the control group was 17.68 (±3.37). The mean IMA level in the AV patients was 0.82±0.023, compared to 0.80±0.017 in the control group. The difference between the two groups was statistically significant (p<0.001). No significant difference was determined among the AV subgroups in terms of IMA levels. Conclusion: Our search of the PubMed database revealed no previous studies investigating IMA levels in patients with AV. Akne vulgaris hastalarında iskemi-modifiye albümin düzeyinin değerlendirilmesiEvaluation of ischemia-modified albumin levels in acne vulgaris patients Amaç: Akne vulgaris (AV), geç çocukluk ve ergenlik çağında sık görülen yaygın dermatolojik hastalıklardan biridir. Bu çalışmada, kutanöz enflamatuvar bir hastalık olan AV'de, iskemi-modifiye albümin (İMA) seviyelerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya klinik olarak AV tanısı konulan 15-30 yaş arasında 74 hasta ile yaş ve cinsiyet açısından eşleştirilmiş AV hastalığı olmayan 60 sağlıklı kontrol alındı. Serum İMA düzeyi, albümin kobalt bağlama testi ile ölçüldü. İskemik durumlarda, kobaltın albümine bağlanmasının azaldığı bilinmektedir. Hasta serumu, kobalt klorid ile karıştırılıp 5 dakika süreyle inkübe edilir. Bu süreçte kobaltın albümine bağlanması sağlanır. İnkübasyondan sonra ditiyotreitol (DTT) eklenerek karıştırılır ve DTT'nin albümine bağlanmamış kobalt ile renkli bir kompleks oluşturması sağlanır. Oluşan renkli kompleks 500 nm dalga boyunda spektrofotometrik olarak ölçülür. Bulgular: AV'li hasta grubunun yaş ortalaması 18,54 (±3,40), kontrol grubunun yaş ortalaması ise 17,68 (±3,37) olarak saptandı. AV hastalarında ortalama İMA düzeyi 0,82±0,023 iken, kontrol grubunda ortalama İMA düzeyi 0,80±0,017 olarak saptandı. İki grup arasında İMA düzeyi açısından istatistiksel olarak anlamlı fark saptandı (p<0,001). AV hastalarının alt grupları arasında İMA düzeyleri açısından anlamlı farklılık tespit edilmedi. Sonuç: PubMed veri tabanı araştırıldığında AV hastalarında İMA düzeylerini araştıran başka çalışmaya r...

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Section: Discussionmentioning

confidence: 99%

Evaluation of ischemia-modified albumin levels in acne vulgaris patients

Gürel¹,

Karadöl²,

Bal³

et al. 2019

TURKDERM

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“…The advances in disease monitoring and treatment are promising with respect to decelerating the progression of disabilities. Current understanding of the fundamental nature of MS is limited, and future goals are directed towards better disease management and repair of injured CNS tissue [1,4] .…”

Section: Introductionmentioning

confidence: 99%

The Three Sisters of Fate in Multiple Sclerosis: Klotho (Clotho), Fibroblast Growth Factor-23 (Lachesis), and Vitamin D (Atropos)

Elli̇dağ

Yılmaz

Kurtuluş³

et al. 2016

Ann Neurosci

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Background: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). Purpose: This study is aimed at evaluating serum soluble Klt (sKlt), FGF-23, and 25-(OH)-vitamin D levels in multiple sclerosis (MS) patients. Methods: Thirty-two relapsing-remitting MS patients (11 males and 21 females; mean age 38.3 years) and 31 age-sex matched healthy controls (12 males and 19 females; median age 38.5 years) were included in this study. All patients were diagnosed with MS according to the criteria of McDonald. Results: Serum sKlt, FGF-23, and P levels were significantly higher in MS patients compared to the control group (p < 0.01, p < 0.01, and p = 0.02, respectively). Serum 25-(OH)-vitamin D and Ca levels were significantly lower in MS patients (p < 0.01 and p = 0.04, respectively). Conclusion: Klt, which is secreted from CP, could be a response to the inflammatory condition in MS. Elevated FGF-23 levels suppress 1α-hydroxylase and upregulates 24α-hydroxylase, which results in a decrease in 1,25-(OH)₂D₃ levels. Thus, the neuroprotective and immunomodulatory effects of vitamin D might not be seen in MS patients.

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“…Other studies indicate that oxidative stress has a major role in the etiology of MS 14. In addition, ischemia modified albumin, a highly sensitive marker for ischemia, is elevated in MS patients 15. In another study, correction of chronic hypoxia with full CBAP treatment resulted in a reduction in inflammation and decreased expression of some inflammatory markers 16.…”

Section: Discussionmentioning

confidence: 95%

Electrophysiological assessment in patients with long term hypoxia

İlik

Kayhan

Karamanli

et al. 2016

NSJ

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Objective:To evaluate visual evoked potentials (VEP) patterns in chronic obstructive pulmonary disease (COPD) patients who were compliant with supplemental oxygen treatment relative to non-compliant COPD patients.Methods:This prospective study protocol was reviewed and approved by the local ethical committee of Selcuk University and the research was performed in the Department of Neurology, Elbistan State Hospital, Kahramanmaras, Turkey from May to October 2014. Blood gas measurements and pulmonary function tests were carried out in patients with advanced stage COPD. The VEP was assessed in both eyes in both compliant and non-compliant patients.Results:The study included 43 patients; 24 (55.8%) of the patients were not in compliance with their supplemental oxygen treatment, while 19 patients (44.2%) received adequate oxygen treatment. There was no statistically significant difference between patients with regards to pulmonary function test results and blood gas measurements. The VEP latency was significantly greater in both eyes of the non-compliant patients.Conclusion:Previous studies have reported prolonged VEP latencies in inflammatory diseases of the central nervous system. Similar electrophysiological findings were observed in our study and we propose that this may be due to oxidative stress, and inflammation that occurs secondary to chronic ischemia.

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Ischemia modified albumin is an indicator of oxidative stress in multiple sclerosis

Cited by 33 publications

References 21 publications

Evaluation of ischemia-modified albumin levels in acne vulgaris patients

Evaluation of ischemia-modified albumin levels in acne vulgaris patients

The Three Sisters of Fate in Multiple Sclerosis: Klotho (Clotho), Fibroblast Growth Factor-23 (Lachesis), and Vitamin D (Atropos)

Electrophysiological assessment in patients with long term hypoxia

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