Ischemia-modified albumin levels are elevated, and thiol/disulfite homeostasis is impaired in Behçet’s disease

Kor, Ahmet; Maraş, Yüksel; Atalar, Ebru; Oğuz, Esra Fırat; Gök, Kevser; Erel, Özcan

doi:10.4274/raed.galenos.2022.36844

raed

2022

DOI: 10.4274/raed.galenos.2022.36844

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Ischemia-modified albumin levels are elevated, and thiol/disulfite homeostasis is impaired in Behçet’s disease

Ahmet Kor¹,

Yüksel Maraş²,

Ebru Atalar³

et al.

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2022

2024

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Cited by 2 publications

References 35 publications

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Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases

Tampa

Mitran

et al. 2022

Medicina

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There is growing evidence that oxidative stress is involved in the pathogenesis of numerous conditions, including dermatological diseases. Various markers are available to assess oxidative stress, but none of these can be considered the ideal marker. Recent studies have shown that ischemia-modified albumin (IMA) is not only an indicator of ischemia, but also a marker of oxidative stress. We have conducted a narrative review to evaluate the role of IMA in dermatological diseases. We have identified 24 original articles that evaluated IMA in skin disorders (psoriasis, acne vulgaris, hidradenitis suppurativa, urticaria, vitiligo and Behcet’s disease) and hair disorders (alopecia areata, androgenetic alopecia and telogen effluvium). The results of the studies analyzed reveal that IMA may be considered a new marker of oxidative stress in dermatological diseases and offer new insights into the pathogenesis of these disorders and the theoretical basis for the development of new, effective, targeted therapies. To the best of our knowledge, this is the first review that gathers up data on the role of IMA in dermatological diseases.

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Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases

Tampa

Mitran

et al. 2022

Medicina

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Evaluation of Thiol Disulfide, Ischemia Modified Albumin, and Prolidase Parameters in Patients With Localized Scleroderma

Akbaş,

Sen,

Kılınç

et al. 2024

Dermatology Practical &Amp; Conceptual

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Introduction: Localized scleroderma is a rare inflammatory skin disease that causes sclerosis in the dermis and subcutaneous tissue. Oxidative stress may play a role in the etiology or be responsible for the chronicity or progression of the disease. Objectives: We aimed to investigate the presence of oxidative stress in patients with localized scleroderma by examining thiol disulfide balance, ischemia-modified albumin (IMA), and prolidase parameters. Methods: Twenty patients over the age of 18, who were diagnosed with localized scleroderma both clinically and histopathologically and 20 control subjects were included in the study. Age, gender, age of disease onset, duration of the disease, and presence of accompanying systemic diseases were questioned and recorded. Lesion type and modified Rodnan and Lossi scores were calculated through dermatological examination. CRP, sedimentation rate, total thiol, native thiol, and disulfide levels indicated by the Erel profile, IMA level, and prolidase levels were measured and compared in both the patient and control groups. Results: Levels of native thiol (p=0.958), total thiol (p=0.979), disulfide (p=0.449), (disulfide/native thiol%) (p=0.368), (disulfide/total thiol%) (p=0.361), (native thiol/total thiol%) (p=0.368), and prolidase (p=0.121) were similar in both patient and control groups. Only IMA was significantly different. No significant relationship was found between the levels of native thiol, total thiol, disulfide, (disulfide/native thiol), (disulfide/total thiol), IMA, prolidase, and Rodnan and Lossi scores. Conclusion: According to the data obtained from this study, we can say that the thiol-disulfide balance is not disrupted and prolidase levels are not affected in localized scleroderma; however, IMA is negatively affected.

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Ischemia-modified albumin levels are elevated, and thiol/disulfite homeostasis is impaired in Behçet’s disease

Cited by 2 publications

References 35 publications

Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases

Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases

Evaluation of Thiol Disulfide, Ischemia Modified Albumin, and Prolidase Parameters in Patients With Localized Scleroderma

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