Ischemia-modified albumin levels in overt and subclinical hypothyroidism

Reddy, Seshadri V.; Suchitra, MM; Pradeep, Vasili; Alok, Sharma; Suresh, V; Bitla, Aparna R.; Rao, Pragna

doi:10.1007/s40618-015-0283-x

Cited by 21 publications

(18 citation statements)

References 40 publications

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“…Studies suggested that elevated IMA levels can be a clinically useful marker of oxidative damage to protein and OXs in hypothyroidism [19]. However, results of IMA in SCH are inconsistent and inconclusive [20][21][22]. In the present study, LT4 replacement in SCH patients caused a significant decrease in IMA levels.…”

Section: Discussionmentioning

confidence: 44%

Lipids and Ischemia Modified Albumin in Mild Subclinical Hypothyroidism: Response to Levothyroxine Replacement

Jaseem¹,

Hegde

Chakrapani

et al. 2017

Asian J Pharm Clin Res

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Objective: Subclinical hypothyroidism (SCH) with thyroid-stimulating hormone (TSH) less than 10 µIU/ml is a common finding discovered during routine thyroid function testing. Thyroxine substitution and its benefits to alleviate dyslipidemia and oxidative stress (OXs) markers at this stage are a matter of debate. Methods:This study aimed to investigate the influence of thyroxine substitution on lipid profile and OXs markers in newly diagnosed SCH subjects. The study included a total number of 50 newly diagnosed (20 treated and 30 untreated), SCH subjects aged 20-50 years with (TSH<10 µIU/ml), and free thyroxine (FT4) levels in the normal range. Patients on medications that could cause thyroid hormone dysfunction, diabetes mellitus, and current or pregnancy during the last 2 years were excluded from the study. Serum TSH, T3, T4, FT4, anti-thyroid peroxidase antibodies, total cholesterol (TC), high-density lipoprotein cholesterol (HDL), triglycerides (TG), low-density lipoprotein cholesterol (LDL), and ischemia modified albumin (IMA) were determined in all subjects at baseline and after 9 months. Results:After thyroxine replacement, a significant decrease in TSH, LDL, IMA and an increase in FT4 were observed. The decrease in TC was not statistically evident. There was no significant change in T3, T4, TG, HDL, after treatment. The untreated group showed an insignificant increase only in TSH. Conclusion:Thyroid substitution therapy has a favorable influence on lipid profile and OXs, where it particularly reduced LDL and IMA.

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Section: Discussionmentioning

confidence: 44%

Lipids and Ischemia Modified Albumin in Mild Subclinical Hypothyroidism: Response to Levothyroxine Replacement

Jaseem¹,

Hegde

Chakrapani

et al. 2017

Asian J Pharm Clin Res

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“…To normalize the effect of albumin levels, the ratio of IMA to albumin (IMAR) was calculated and was found to be significantly increased in these athletes after running than the levels before physical activity (p = 0.000). Increased IMA levels in pre-eclampsia were found to be associated with increased IMAR in other studies carried out in diverse medical conditions [22,23].…”

Section: Discussionmentioning

confidence: 50%

Status of Ischemia Modified Albumin in Athletes Before and After Moderate Exercise

Dahiya¹,

Kumar²,

Dhankhar³

et al. 2018

TOBIOMJ

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Background: Ischemia Modified Albumin (IMA) is considered as an early marker of ischemia. Its levels may be altered in any clinical condition where an ischemic event is involved. Skeletal muscle ischemia is associated with severe exercise but may also occur in moderate form of exercise. Objective: The levels of IMA were estimated before and after thirty minutes of moderate exercise in students undergoing athletic training. Methods: The present study was conducted on 120 young adult students undergoing athletic training program in the physical education department. All the subjects were healthy with normal body mass index and blood pressure. Their serum samples were collected before and after running for half an hour on the racing track and were analyzed for IMA colorimetrically and the data was subjected to appropriate statistical analysis. Results: The levels of IMA were found to be statistically significantly higher after exercise as compared to those before exercise (p = 0.005). The ratio of IMA to albumin (IMAR) was also found to be significantly higher after exercise as compared to that before exercise (p=0.000). Conclusion: It may be concluded that the skeletal muscle ischemia induced by moderate aerobic exercise is associated with an increased conversion of albumin to IMA.

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“…Level of IMA in hypothyroidism has been a controversial issue since long. Reddy SV et al 9 have shown increased IMA in both overt and subclinical hypothyroidism and have shown significant positive correlation of IMA with TSH in overt hypothyroidism. In yet another study done by Ma S.G et al, IMA was found to be higher in overt hypothyroidism.…”

Section: Discussionmentioning

confidence: 94%

“…At one end studies have shown increased level of IMA in cases of hypothyroidism, while at the same times studies have shown lower level of IMA. [9][10] There are even studies which have not found any difference in the level of IMA in normal control and hypothyroid subjects . 11 Hence this study was planned to study the level of IMA in newly diagnosed subjects of hypothyroidism who were not on any treatment.…”

Section: Introductionmentioning

confidence: 99%

Level of IMA in newly diagnosed untreated hypothyroid subjects diagnosed during routine screening at Tertiary Care Hospital in North India

2020

IJCBR

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Introdcution: Aim of this study was to assess the level of ischemia modified albumin(IMA) in newly diagnosed untreated hypothyroid subjects. Materials and Methods: Serum IMA assessment was done by Barr et al method 30 newly diagnosed patients of hypothyroidism For the control group 50 normal healthy euthyroid adults were selected. TSH was done by one-step sandwich ELISA, and fT3, fT4 was done by one-step competitive ELISA method. Data were presented as mean ± standard deviation (SD). Results: Serum IMA was not found to be statistically different between hypothyroid and euthyroid control group. Conclusion: Contrary to the findings of majority of studies done on this subject, our study has not shown any significant elevation of IMA in hypothyroid subjects as compared to euthyroid subjects. IMA level in subjects of hypothyroidism has been a controversial issue since long. Assessment of cIMA should be done in association with other oxidative stress marker, and their correlation if any should be studied in a large cohort.

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Ischemia-modified albumin levels in overt and subclinical hypothyroidism

Abstract: Increase of MDA and IMA levels with decreased antioxidant status indicate the presence of OS in hypothyroid patients, which was more pronounced in OHT patients. Elevated levels of IMA can be a clinically useful marker of protein oxidative damage and OS in hypothyroidism.

Cited by 21 publications

References 40 publications

Lipids and Ischemia Modified Albumin in Mild Subclinical Hypothyroidism: Response to Levothyroxine Replacement

Lipids and Ischemia Modified Albumin in Mild Subclinical Hypothyroidism: Response to Levothyroxine Replacement

Status of Ischemia Modified Albumin in Athletes Before and After Moderate Exercise

Level of IMA in newly diagnosed untreated hypothyroid subjects diagnosed during routine screening at Tertiary Care Hospital in North India

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