Ischemic Brain Neurodegeneration

Pluta, Ryszard

doi:10.3390/ijms23126441

Cited by 1 publication

(1 citation statement)

References 26 publications

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“…Brain ischaemic, which is also called cerebral ischaemia or ischaemic stroke, occurs when the blood flow to the brain is insufficient [1][2][3], causing deprivation of both oxygen and glucose to the brain and upsetting the balance of metabolism in the nervous system [4,5]. These may include abrupt numbness or weakness in one side of the body, particularly in the arms or legs, as well as facial drooping and difficulty speaking or understanding speech.…”

Section: Introductionmentioning

confidence: 99%

"The Neuroprotection Effect of GLP-1 Receptor in Murine Stroke Model"

Lyu,

Zhang

2024

BJSTR

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Background and Purposes: Stroke ranks as the world second most frequent cause of death. Eight-five percent of strokes are ischaemic, meaning a reduction of blood supply and permanent neurological disabilities with both mental and physical manifestations. Glucagon-like peptide 1(GLP-1) is a neuropeptide that has shown neuro-protective properties. In this study, we assessed the neuroprotective effect of GLP-1 receptor agonist in a murine model of global cerebral ischaemia stroke.Methods: Adult male C57BL/6 mice (25 to 30g) were subjected to transient global ischaemia by means of occlusion of the bilateral internal carotid arteries for 20 minutes. The mice were separated into three groups of 10: normal control group (n=10); transient global ischaemia group (n=10); and transient global ischaemia with GLP-1 receptor agonist treated group (n=10). Behavioural tests were performed before the mice were sacrificed on day 5. Real-time polymerase chain reaction was used to identify the molecular markers of neuronal damage.Results: Up-regulation of neuron nuclear, synapse and neuro-filament markers was found in the group treated with the GLP-1 receptor agonist.Conclusions: GLP-1 receptor agonist has neuro-protective effect, as shown by real-time polymerase chain reaction and western-blot detection, and could improve loco-motor function on mice global ischaemic model.

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