Ischemic colitis: A forgotten entity. Results of a retrospective study in 118 patients

Sherid, Muhammed; Sifuentes, Humberto; Samo, Salih; Sulaiman, Samian; Husein, Husein; Tupper, Ruth; Sethuraman, Sankara; Spurr, Charles L.; Vainder, John A.; Sridhar, Subbaramiah

doi:10.1111/1751-2980.12182

Cited by 17 publications

(25 citation statements)

References 43 publications

(270 reference statements)

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“…The left colon was the most commonly affected segment, while the rectum and ascending colon were the least affected segments. These findings represent general characteristics of IC and are in agreement with previously reported data [1, 2, 5–7]. However, we found that patients with predisposing factors did not exhibit these characteristics.…”

Section: Discussionsupporting

confidence: 93%

“…Many previous studies have referred to predisposing and/or risk factors of IC using terms such as predisposing factor/condition, risk factor, medical condition, comorbidity, underlying medical illness, or etiological factor [5, 8–11, 13, 14]. However, based on our definition, most of the conditions considered in previous studies would be classified as risk factors, not predisposing factors.…”

Section: Discussionmentioning

confidence: 99%

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Predisposing Factors of Ischemic Colitis: Data from 14 Years of Experience in a Single Center

Seo

Choi

Han

et al. 2017

Gastroenterology Research and Practice

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Background and Aims While several case reports on ischemic colitis (IC) suggest the presence of predisposing causative factors, a few studies have investigated the predisposing factors in IC. This study aimed to identify the characteristics of patients with IC, particularly focusing on the predisposing factors. Methods We conducted a single-center, retrospective analysis of 159 patients with IC. Clinical characteristics, laboratory data, endoscopic findings, and medical records were reviewed. Data were compared between groups of patients defined according to the predisposing factors. The predisposing factors are defined as temporary states or episodic events occurring within a week before the development of IC such as colonoscopy, enema, use of laxatives, heavy drinking, pancreatitis, shock, and burn. Results Compared to the group of patients without predisposing factors of IC, the group of patients with predisposing factors was characterized by a relatively higher prevalence of male sex (56.9% versus 33.3%, p = 0.005), younger age (60.9 ± 15.4 versus 67.2 ± 13.4 years, p = 0.010), lower incidence of hypertension (43.1% versus 60.2%, p = 0.044), and fewer risk factors (1.24 ± 1.18 versus 1.82 ± 1.22, p = 0.005). Conclusions Among men with predisposing factors, IC may develop even at a relatively younger age and in the absence of multiple risk factors, suggesting that predisposing factors may be involved in the pathogenesis of IC.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Predisposing Factors of Ischemic Colitis: Data from 14 Years of Experience in a Single Center

Seo

Choi

Han

et al. 2017

Gastroenterology Research and Practice

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“…Ischaemic colitis (IC), first described by Boley et al [1] and defined as inadequate perfusion caused by impaired colonic blood supply leading to colonic inflammation, is one of the most common gastrointestinal vascular diseases. It frequently occurs in the elderly with a female predominance [2][3][4][5][6], but younger patients may also be affected [7][8][9]. Although underestimated because many cases are transient and misdiagnosed, the incidence of IC in the general population ranges from 4.5 to 44 cases per 100 000 persons per year [10].…”

Section: Introductionmentioning

confidence: 99%

The predictors of the severity of ischaemic colitis: a systematic review of 2823 patients from 22 studies

et al. 2016

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“…The main predisposing factors for IBS are vascular factors and bowel factors. Hypoperfusion, vascular surgery requiring aortic clamping, vasospasm, vasoconstrictor drugs and thromboembolism from hypercoagulable states or cardiac emboli may lead to IBS 30. O'Farrell et al assessed the risk of thromboembolic disease in patients with PC undergoing ADT.…”

Section: Discussionmentioning

confidence: 99%

Association between ischaemic bowel syndromes and androgen deprivation therapy in patients with prostate cancer: a retrospective cohort study

Chiang

Huang

et al. 2017

BMJ Open

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ObjectiveThis study investigated the risk of ischaemic bowel syndrome (IBS) in androgen deprivation therapy (ADT) users to explore the long-term outcomes of patients with prostate cancer (PC) receiving ADT treatment.MethodsWe performed a population-based retrospective cohort study. All the clinical information of the study participants were acquired from the Longitudinal Health Insurance Database for Catastrophic Illness Patients in Taiwan. We extracted data for all the patients newly diagnosed with prostate malignancy (ICD-9-CM 185 or C61 in ICD-10-CM) from 2000 to 2008. The patients were then divided into two groups: 7160 male ADT cohort receiving ADT and 7160 male non-ADT comparison group frequency matched by age and index year of ADT treatment of the ADT group. Cox proportional hazard regression was used to estimate the adjusted HR and 95% CIs of the IBS risk.ResultsNo significant difference was noted in the overall incidence rate for IBS between the ADT and non-ADT cohorts (0.86 and 0.89 per 1000 person–year, respectively, p=0.89). Even after adjusting for potential risk factors, a 1.06-fold risk of IBS (95% CI 0.62 to 1.82, p=0.82) was observed in the ADT cohort relative to the non-ADT cohorts. Moreover, we stratified the ADT cohort by time point of ADT treatment after PC diagnosis. Different IBS incidence rates were observed among the early ADT, late-ADT and non-ADT users at 0.77, 1.23 and 0.89 per 1000 person-years, respectively; nonetheless, the difference was not statistically significant. Moreover, no difference was found between the ADT treatment types and IBS risk, including sole orchiectomy, sole luteinising-hormone-releasing hormone and both.ConclusionsResults showed that ADT treatment in patients with PC is not an independent factor for IBS incidence. Large sample sizes for patients with IBS with patients with PC who had received ADT treatment are needed for further study.

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Ischemic colitis: A forgotten entity. Results of a retrospective study in 118 patients

Cited by 17 publications

References 43 publications

Predisposing Factors of Ischemic Colitis: Data from 14 Years of Experience in a Single Center

Predisposing Factors of Ischemic Colitis: Data from 14 Years of Experience in a Single Center

The predictors of the severity of ischaemic colitis: a systematic review of 2823 patients from 22 studies

Association between ischaemic bowel syndromes and androgen deprivation therapy in patients with prostate cancer: a retrospective cohort study

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