Ischemic colitis associated with acute carbon monoxide poisoning

Dueñas‐Laita, Antonio; Mena-Martín, F.J.; Roquelai-Ruiz, Pablo; Gil-Simon, Paula; Barrio, Jesús; Martı́n-Escudero, Juan Carlos

doi:10.1080/15563650701546227

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…The most susceptible organs are the brain and myocardium but ischemic insult may also affect the bowel. Two other cases of acute intestinal ischemia following CO intoxication have been reported so far, one with fatal, massive mesenteric ischemia complicating an acute coronary syndrome with acute pulmonary edema and another with sigmoid colon ischemia and favorable course [11,12]. None had the macroscopic appearance of a localized colon tumor.…”

Section: Discussionmentioning

confidence: 95%

“…None had the macroscopic appearance of a localized colon tumor. Ischemic lesions of the colon entail detectable injury in the superficial part of the mucosa within one hour [12]. Further damage is observed in deeper layers in several hours (Figure 2, 3, 4).…”

Section: Discussionmentioning

confidence: 96%

“…Even if myocardial damage may be present in nearly 40% of poisoned individuals, the most common cause of death is anoxic brain injury [8][9][10]. Mesenteric ischemia may also occur following CO exposure, leading mostly to ischemic colitis [11,12]. In spite of the above concerns, solid organ procurements from CO intoxicated donors and from some having tumors, though controversial, have been reported [4,7,10].…”

Section: Introductionmentioning

confidence: 99%

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Unforeseen Pseudotumoral Colitis in Deceased Donor with Carbon Monoxide Intoxication

Lupașcu¹,

Movila²,

Andriesi³

et al. 2014

J Clin Toxicol

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Carbon monoxide intoxication is a well-known cause of hypoxic injury primarily to the central nervous system and myocardium, but the bowel may be also vulnerable. Patients succumbing to carbon monoxide poisoning are usually considered unsuitable for organ procurement and they are routinely rejected in many transplant centers. As the organ supply is by far insufficient to meet the needs of patients from the waiting lists for transplant, there is a greater effort to increase the donor organ pool. Therefore special attention is being devoted to such "marginal" or "high-risk "donors. Similarly, tumors revealed during organ procurement require careful consideration in the evaluation of organ donors and transplant recipients. We herein report a multiorgan procurement from a victim of carbon monoxide poisoning who underwent a prolonged cardiopulmonary resuscitation and was intraoperatively diagnosed with a right colon tumor. Intraoperative frozen section examination ruled out malignancy and revealed an acute ischemic colitis. It is suggested that patients dying of carbon monoxide poisoning who are considered appropriate donors, may have intraoperatively revealed pseudotumoral ischemic colitis which does not preclude multiorgan procurement.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 96%