Ischemic heart disease in systemic inflammatory diseases. An appraisal

Gargiulo, Paola; Marsico, Fabio; Parente, António; Paolillo, Stefania; Cecere, Milena; Casaretti, Laura; Pellegrino, Angela Maria; Formisano, Tiziana; Fabiani, Irma; Soricelli, Andrea; Trimarco, Bruno; Perrone‐Filardi, Pasquale

doi:10.1016/j.ijcard.2013.11.048

Cited by 35 publications

(19 citation statements)

References 76 publications

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“…The most likely mechanism is high-grade inflammation in RA. Studies investigating the relationship between RA and CAD suggested a direct link between the degree of inflammation and the risk of CV events [32]. Pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6 were well known to contribute to atherosclerosis development and played an [33].…”

Section: Discussionmentioning

confidence: 99%

Relationship of rheumatoid arthritis and coronary artery disease in the Korean population: a nationwide cross-sectional study

et al. 2019

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Background: Rheumatoid arthritis (RA) is known to be associated with coronary artery diseases (CAD). Previous studies of the association between RA and CAD were reported mainly in non-Asian groups. We aimed to examine the prevalence of RA and the relationship between RA and CAD in South Korea. Methods: We conducted a nationwide cross-sectional study by using the Korea National Health and Nutrition Examination Survey, which collected data for four years between 2008 and 2012. A total of 25,828 eligible participants were included. To balance the distribution of baseline characteristics, we used propensity scorematching. A multivariable logistic regression model was employed and we calculated the odds ratios (ORs) and 95% confidence intervals (CI) for the odds of the participants with RA on CAD prevalence. Results: The prevalence of RA in Korea from 2008 to 2012 was 0.6% and RA was predominant among elderly women. The prevalence of CAD in patients with RA was significantly higher than in general population. After propensity score-matching to balance the confounding factors, RA was significantly associated with CAD (OR 2.97, 95% CI 1.15-7.68, P = 0.02). Conclusions: The prevalence of RA in South Korea was comparable to the worldwide data, and the presence of CAD in RA patients was more than twofold .

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Section: Discussionmentioning

confidence: 99%

Relationship of rheumatoid arthritis and coronary artery disease in the Korean population: a nationwide cross-sectional study

et al. 2019

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“…The side effects differ within the whole group. csDMARDs have a potential to reduce atherogenesis and progression of ATS [64]. Thus, the early initiation of therapy with scDMARDs can prevent development of CVDs [65].…”

Section: Immunosuppressive Therapy and Its Effect On CV Riskmentioning

confidence: 99%

Atherosclerosis in Rheumatology: Old and New Insights

Oreská¹,

Tomčík²

2020

Atherosclerosis, Arteriosclerosis and Arteriolosclerosis

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Cardiovascular diseases are the leading cause of morbidity and mortality in general population worldwide. There is an increasing significance of cardiovascular risk in the field of rheumatology, and accordingly, the evidence on the relation between immune system disorders and atherosclerosis has been substantially growing especially in last decades. Since novel immune and metabolic factors are considered to participate in pathogenesis of atherosclerosis and increased cardiovascular risk in rheumatic patients, they are getting to the forefront of the research. Since novel therapeutic approaches have improved survival of rheumatic patients, and decreased morbidity caused by rheumatic disease activity and damage, the significance of other comorbidities leading to premature mortality has arisen. Nevertheless, appropriate recommendations for the management of cardiovascular risk are still lacking. Recently, European League Against Rheumatism (EULAR) recommendations for management of the cardiovascular risk and comorbidities in patients with inflammatory arthropathies have been published. However, the cardiovascular management of these patients is still suboptimal. In addition, the situation in other orphan diseases such as idiopathic inflammatory myopathies, systemic sclerosis and others is even more uncertain and strongly requires further research. This chapter provides an overview of epidemiology, pathogenesis, clinical manifestations, screening and management of atherosclerosis in patients with rheumatic diseases.

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“…Савина Жанна Евеньевна -к.м.н., врач функциональной диагно-стики; e-mail: jeanneSav@yandex.ru Сердечно-сосудистые осложнения (ССО), обуслов-ленные развитием артериальной гипертонии (АГ) и ран-ним атеросклеротическим поражением сосудов, являются одними из основных причин летальности при ревматиче-ских заболеваниях [1][2][3][4].…”

Section: контактная информацияunclassified

Specific features of hypertension in patients with systemic lupus erythematosus

Savina¹,

Шилкина²

2015

Ter. arkh.

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РезюмеЦель исследования. Изучение особенностей формирования и течения артериальной гипертонии (АГ) у больных системной красной волчанкой (СКВ). Материалы и методы. Обследовали сопоставимых по возрасту и полу 106 больных: 47 -с СКВ, 55 -с гипертонической болезнью (ГБ). У всех пациентов определяли уровень ренина в плазме крови, рассчитывали концентрацию антигена фактора Виллебранда в сыворотке крови, проводили подсчет десквамированных эндотелиоцитов, выполняли суточное мониторирование артериального давления (СМАД) и допплерографию сонных артерий. Результаты. У больных СКВ с синдромом АГ уровень среднего диастолического артериального давления (ДАД) при сравнении с группой пациентов с ГБ составил 86,5 (79,5; 93,5) Aim.To study the specific features of the development and course of hypertension in patients with systemic lupus erythematosus (SLE). Subjects and methods. A total of 106 age-and sex-matched patients, including 47 with SLE and 55 with hypertensive disease (HD), were examined. In all the patients, plasma renin levels were determined; serum von Willebrand factor antigen concentrations were estimated; desquamated endothelial cell counts were calculated; and 24-hour blood pressure (BP) monitoring (BPM) and Doppler ultrasound of carotid arteries performed. Results. In the patients with SLE and hypertension compared to those with HD, the mean diastolic BP (DBP) was 86.5 (79.5-93.5) mm Hg versus 80.5 (77-90) mm Hg (daytime) and 78 (69-91.5) mm Hg versus 72.5 (64-78) mm Hg (nighttime) (p<0.05), and there was also a decrease in daily DBP index (5 [0.5-15]% versus 11 [7.5-18]% (p<0.02)). The plasma renin levels were 1.67 (0.78-2.47) and 0.49 (0.25-0.81) ng/ml/h in the patients with SLE and in those with HD, respectively,) ng/ml/h in the control group (р=0.0001). An atherosclerotic vascular lesion was found in 52 and 32% of the patients with SLE and those with HD, respectively. The von Willebrand factor antigen levels were 1.63 (0.81-3.36) and 0.29 (0.23-2.8) IU/ml in these patients, respectively (p=0.04). The plasma circulating endothelial cell counts were also significantly higher in the patients with SLE and hypertension than in those with •10 4 /l and 5 [3-8]•10 4 /l (p<0.01). Conclusion. The patients with SLE and hypertension show a high rate of its hyper-renin states, a propensity for nocturnal hypertension, an increase in DBP, and obvious vascular endothelial regulatory dysfunction.

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Ischemic heart disease in systemic inflammatory diseases. An appraisal

Cited by 35 publications

References 76 publications

Relationship of rheumatoid arthritis and coronary artery disease in the Korean population: a nationwide cross-sectional study

Relationship of rheumatoid arthritis and coronary artery disease in the Korean population: a nationwide cross-sectional study

Atherosclerosis in Rheumatology: Old and New Insights

Specific features of hypertension in patients with systemic lupus erythematosus

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