Ischemic Hepatitis – Intercorrelated Pathology

Abstract

Ischemic hepatitis is an important

Liver Injury in Patients Hospitalized with Coronavirus Disease 2019 Correlates with Hyperinflammatory Response and Elevated Interleukin-6

“…( 8 ) This may be supported by the higher rates of aspartate aminotransferase (AST) over alanine aminotransferase (ALT) elevations seen in COVID‐19‐related liver injury, which is consistent with zone 3 necrosis and ischemic liver injury. ( 9 ) A final possibility is that COVID‐19 liver injury may result from the body’s hyperinflammatory response to COVID‐19. This could be in the form of general immune activation caused by the release of circulating cytokines similar to many systemic viral infections in which the liver suffers from “bystander hepatitis.” ( 10‐12 ) In turn, this response may progress into a phenomenon akin to a “cytokine storm” characterized by an exaggerated and aberrant inflammatory response with severe systemic impact, including extremely high levels of inflammatory markers, such as ferritin and C‐reactive protein (CRP), fevers, and cytopenias, with some patients presenting with secondary hemophagocytic lymphohistiocytosis (sHLH).…”

“…(8) This may be supported by the higher rates of aspartate aminotransferase (AST) over alanine aminotransferase (ALT) elevations seen in COVID-19-related liver injury, which is consistent with zone 3 necrosis and ischemic liver injury. (9) A final possibility is that COVID-19 liver injury may result from the body's hyperinflammatory response to COVID-19. This could be in the form of general immune activation caused by the release of circulating cytokines similar to many systemic viral infections in which the liver suffers from "bystander hepatitis."…”

“Bright Band Sign” A Grayscale Ultrasound Finding in Hepatic Infarction

“…All of our cases demonstrated echogenic bands within the infarcted portions of the liver, which may represent specular reflections returned from the intact portal triads, although this remains speculative, as we do not have enough evidence to support this potential association. The most susceptible region to ischemia in the hepatic acinus, the functional unit of the liver, would be in acinar zone 3 around the central vein, as it is furthest from hepatic arteries . Acinar zone 1, encircling the portal triads where the hepatic arteries enter, receives the highest amount of oxygen and thus is less susceptible to ischemic changes.…”

Prevalence of gestational thrombocytopenia among selected group of pregnant women attended to soba university hospital, Sudan, July-September 2016

“…Platelet transfusions may be required together with the factor VIII replacement if the platelet count is <20.000/ìL antenatally, prior to any invasive procedures, if bleeding occurs or if platelet count is <50.000/ìL around delivery. 6 General measures, including avoidance of aspirin, non-steroidal antiinflammatory drugs, and intramuscular injections, should also be considered depending on the platelet level and stability. 7 Rationale: Gestational thrombocytopenia may lead to severe complications for both pregnant lady and her fetus.…”