2005
DOI: 10.1161/circulationaha.104.486720
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Ischemic Mitral Regurgitation on the Threshold of a Solution

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Cited by 440 publications
(301 citation statements)
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References 163 publications
(177 reference statements)
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“…7,11 Effect of anaesthetics and dobutamine on MR Secondary MR also varies dynamically with loading con ditions that modulate LV volume. 14 Regurgitant volume decreases substantially in response to unloading drugs, which is achieved through a reduction in EROA, but not through a change in the gradient across the mitral valve. Reduction of orifice area is likely to be related to a decrease in LV volume.…”
Section: Exercise-induced Changes In Mrmentioning
confidence: 98%
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“…7,11 Effect of anaesthetics and dobutamine on MR Secondary MR also varies dynamically with loading con ditions that modulate LV volume. 14 Regurgitant volume decreases substantially in response to unloading drugs, which is achieved through a reduction in EROA, but not through a change in the gradient across the mitral valve. Reduction of orifice area is likely to be related to a decrease in LV volume.…”
Section: Exercise-induced Changes In Mrmentioning
confidence: 98%
“…13 Acute MR commonly occurs as a secondary complication of acute left ventricular (LV) remodelling and dysfunction without structural valvular abnormalities, resulting from increased leaflet tethering and reduced mitral closing forces. 14 However, the severity of secondary MR varies widely, and even a mild form of MR in the acute setting of myocardial infarction is associated with poor progno sis. 15 Patients might also present with acute dyspnoea or flash pulmonary oedema.…”
Section: Factors That Influence Mrmentioning
confidence: 99%
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“…In addition, pathologic states of the left ventricle (ie, ischemia, cardiomyopathy) can have deleterious effects on mitral valve function, causing mitral annular deformation, papillary muscle displacement, and LV remodeling, resulting in tethering of the mitral valve and lack of coaptation of the leaflets. 25,26 This can result in functional mitral regurgitation.…”
Section: Mitral Regurgitationmentioning
confidence: 99%