Ischemic Preconditioning Is Present in Patients With Non–ST Elevation Myocardial Infarction Screened With Electrocardiogram-Derived Moderate Obstructive Sleep Apnea

Borczynski, Elizabeth; Suba, Sukardi; Mackin, Lynda A; Mortara, David; Badilini, Fabio; Rodway, George W.; Pelter, Michele M.

doi:10.1097/jcn.0000000000000926

Cited by 2 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, lifestyle and environmental factors unique to higher altitudes could contribute. Recent research suggests that conditions predisposing to hypoxia, such as sleep apnea, may confer cardioprotective effects through mechanisms like myocardial angiogenesis [41][42][43][44]. In this context, we hypothesize that the reduced partial pressure of oxygen at higher altitudes may confer protective cardiovascular effects.…”

Section: Plos Onementioning

confidence: 93%

Epidemiological characterization of ischemic heart disease at different altitudes: A nationwide population-based analysis from 2011 to 2021 in Ecuador

Ortiz-Prado,

Izquierdo-Condoy,

Fernández-Naranjo

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Background Cardiovascular diseases, including ischemic heart disease, are the leading cause of premature death and disability worldwide. While traditional risk factors such as smoking, obesity, and diabetes have been thoroughly investigated, non-traditional risk factors like high-altitude exposure remain underexplored. This study aims to examine the incidence and mortality rates of ischemic heart disease over the past decade in Ecuador, a country with a diverse altitude profile spanning from 0 to 4,300 meters. Methods We conducted a geographic distribution analysis of ischemic heart disease in Ecuador, utilizing hospital discharge and mortality data from the National Institute of Census and Statistics for the years 2011–2021. Altitude exposure was categorized according to two distinct classifications: the traditional division into low (< 2,500 m) and high (> 2,500 m) altitudes, as well as the classification proposed by the International Society of Mountain Medicine, which delineates low (< 1,500 m), moderate (1,500–2,500 m), high (2,500–3,500 m), and very high (3,500–5,800 m) altitudes. Findings From 2011–2021, we analyzed 49,765 IHD-related hospital admissions and 62,620 deaths. Men had an age-adjusted incidence rate of 55.08/100,000 and a mortality rate of 47.2/100,000, compared to 20.77/100,000 and 34.8/100,000 in women. Incidence and mortality surged in 2020 by 83% in men and 75% in women. Altitudinal stratification revealed higher IHD rates at lower altitudes (<2500 m), averaging 61.65 and 121.8 per 100,000 for incidence and mortality, which declined to 25.9 and 38.5 at elevations >2500 m. Men had more pronounced rates across altitudes, exhibiting 138.7% and 150.0% higher incidence at low and high altitudes respectively, and mortality rates increased by 48.3% at low altitudes and 23.2% at high altitudes relative to women. Conclusion Ecuador bears a significant burden of ischemic heart disease (IHD), with men being more affected than women in terms of incidence. However, women have a higher percentage of mortality post-hospital admission. Regarding elevation, our analysis, using two different altitude cutoff points, reveals higher mortality rates in low-altitude regions compared to high-altitude areas, suggesting a potential protective effect of high elevation on IHD risk. Nevertheless, a definitive dose-response relationship between high altitude and reduced IHD risk could not be conclusively established.

show abstract

Section: Plos Onementioning

confidence: 93%

Epidemiological characterization of ischemic heart disease at different altitudes: A nationwide population-based analysis from 2011 to 2021 in Ecuador

Ortiz-Prado,

Izquierdo-Condoy,

Fernández-Naranjo

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

Hospital-Based Electrocardiographic Monitoring: The Good, the Not So Good, and Untapped Potential

Pelter

2024

American Journal of Critical Care

View full text Add to dashboard Cite

Continuous electrocardiographic (ECG) monitoring was first introduced into hospitals in the 1960s, initially into critical care, as bedside monitors, and eventually into step-down units with telemetry capabilities. Although the initial use was rather simplistic (ie, heart rate and rhythm assessment), the capabilities of these devices and associated physiologic (vital sign) monitors have expanded considerably. Current bedside monitors now include sophisticated ECG software designed to identify myocardial ischemia (ie, ST-segment monitoring), QT-interval prolongation, and a myriad of other cardiac arrhythmia types. Physiologic monitoring has had similar advances from noninvasive assessment of core vital signs (blood pressure, respiratory rate, oxygen saturation) to invasive monitoring including arterial blood pressure, temperature, central venous pressure, intracranial pressure, carbon dioxide, and many others. The benefit of these monitoring devices is that continuous and real-time information is displayed and can be configured to alarm to alert nurses to a change in a patient’s condition. I think it is fair to say that critical and high-acuity care nurses see these devices as having a positive impact in patient care. However, this enthusiasm has been somewhat dampened in the past decade by research highlighting the shortcomings and unanticipated consequences of these devices, namely alarm and alert fatigue. In this article, which is associated with the American Association of Critical-Care Nurses’ Distinguished Research Lecture, I describe my 36-year journey from a clinical nurse to nurse scientist and the trajectory of my program of research focused primarily on ECG and physiologic monitoring. Specifically, I discuss the good, the not so good, and the untapped potential of these monitoring systems in clinical care. I also describe my experiences with community-based research in patients with acute coronary syndrome and/or heart failure.

show abstract

Ischemic Preconditioning Is Present in Patients With Non–ST Elevation Myocardial Infarction Screened With Electrocardiogram-Derived Moderate Obstructive Sleep Apnea

Cited by 2 publications

References 26 publications

Epidemiological characterization of ischemic heart disease at different altitudes: A nationwide population-based analysis from 2011 to 2021 in Ecuador

Epidemiological characterization of ischemic heart disease at different altitudes: A nationwide population-based analysis from 2011 to 2021 in Ecuador

Hospital-Based Electrocardiographic Monitoring: The Good, the Not So Good, and Untapped Potential

Contact Info

Product

Resources

About