Ischemic preconditioning provides no additive clinical value in liver resection of cirrhotic and non-cirrhotic patients under portal triad clamping: A prospective randomized controlled trial

Personalized stepwise vascular control during complex hepatectomy involving hepatocaval confluence

“…Certain studies have demonstrated that ischaemic preconditioning and intermittent PT clamping have the beneficial effects of protecting against IR injury for patients undergoing liver resection . However, other authors have claimed that ischaemic preconditioning provides no additional clinical value in liver resection under PT clamping . Moreover, the typical pre‐clamping time is approximately 10–15 min, which is similar to the PT clamping time in this study.…”

Pre‐conditions for eliminating mitochondrial dysfunction and maintaining liver function after hepatic ischaemia reperfusion

“…Recently, Ye et al . have demonstrated that IPC exerts no apparent effects on decreasing the level of serum transaminases and rates of morbidity and mortality. Because there is inevitable heterogeneity among patients, IPC varies with ischaemia time and respiration time, and an IPC protocol has various influences on hepatic IR.…”

Ischemic preconditioning modulates ROS to confer protection in liver ischemia and reperfusion

“…A randomized control trial involving 84 patients that underwent major liver resection found no clinical benefit to IPC prior to resection using an intermittent Pringle maneuver (Scatton et al, 2011[66]). In a similar study involving 100 patients, IPC prior to liver resection also using a Pringle maneuver did not provide any clinical benefit in terms of length of hospitalization, morbidity, or mortality (Ye et al, 2014[91]). A study involving 22 participants undergoing adult-to-adult living liver transplantation did not find any clinically significant benefit for the donor nor the recipient in terms of morbidity or mortality (Andreani et al, 2010[1]).…”