Ischemic-reperfusion of unilateral external iliac artery in rat: A new model for vasculitic femoral neuropathy

Muthuraman, Arunachalam; Ramesh, Muthusamy

doi:10.1016/j.neulet.2016.06.015

Cited by 7 publications

(8 citation statements)

References 52 publications

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“…VPN exhibits the clinical features of neuropathic pain and impaired peripheral nerve function. VPN has been documented to occur in a variety of clinical situations such as in patients suffering from vascular occlusive diseases, necrotizing vasculitides, diabetes mellitus and trauma, or while receiving vascular surgeries …”

Section: Introductionmentioning

confidence: 99%

“…Inducing ischaemia–reperfusion (IR) in the rat femoral artery has been proposed as an animal model of VPN, which can be achieved via occluding the femoral artery for 4 hours followed by reperfusion . This VPN model mimics the development of pain in the lower extremities related to acute peripheral arterial ischaemic events followed by reperfusion, which can be encountered in certain clinical situations such as in managing patients with thrombosis formation on atherosclerotic lesions, arterial embolism from the heart or aorta, aortic dissection, and compartment syndrome after extremity vascular injury . VPN induced by IR has been reported to cause hind paw allodynia and hyperalgaesia, impaired motor nerve conduction velocity (MNCV), neuronal oedema and axonal degeneration in the sciatic nerve, and changes to the inflammatory and oxidative markers in serum and the sciatic nerve .…”

Section: Introductionmentioning

confidence: 99%

“…VPN has been documented to occur in a variety of clinical situations such as in patients suffering from vascular occlusive diseases, necrotizing vasculitides, diabetes mellitus and trauma, or while receiving vascular surgeries. [2][3][4] Inducing ischaemia-reperfusion (IR) in the rat femoral artery has been proposed as an animal model of VPN, which can be achieved via occluding the femoral artery for 4 hours followed by reperfusion. 3 This VPN model mimics the development of pain in the lower extremities related to acute peripheral arterial ischaemic events followed by reperfusion, which can be encountered in certain clinical situations such as in managing patients with thrombosis formation on atherosclerotic lesions, arterial embolism from the heart or aorta, aortic dissection, and compartment syndrome after extremity vascular injury.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6] VPN induced by IR has been reported to cause hind paw allodynia and hyperalgaesia, impaired motor nerve conduction velocity (MNCV), neuronal oedema and axonal degeneration in the sciatic nerve, and changes to the inflammatory and oxidative markers in serum and the sciatic nerve. 3,4,7,8 Our recent study also revealed that early activation of nuclear factor-κB (NF-κB)-mediated neuroinflammation in the sciatic nerve contributes to the development of allodynia, hyperalgaesia and the debilitating symptoms of VPN. 9 Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenol found in a few edible materials, such as in red grape skins, peanuts, and red wine.…”

Section: Introductionmentioning

confidence: 99%

“…This VPN model mimics the development of pain in the lower extremities related to acute peripheral arterial ischaemic events followed by reperfusion, which can be encountered in certain clinical situations such as in managing patients with thrombosis formation on atherosclerotic lesions, arterial embolism from the heart or aorta, aortic dissection, and compartment syndrome after extremity vascular injury . VPN induced by IR has been reported to cause hind paw allodynia and hyperalgaesia, impaired motor nerve conduction velocity (MNCV), neuronal oedema and axonal degeneration in the sciatic nerve, and changes to the inflammatory and oxidative markers in serum and the sciatic nerve . Our recent study also revealed that early activation of nuclear factor‐κB (NF‐κB)‐mediated neuroinflammation in the sciatic nerve contributes to the development of allodynia, hyperalgaesia and the debilitating symptoms of VPN …”

Section: Introductionmentioning

confidence: 99%

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Resveratrol alleviates nuclear factor‐κB‐mediated neuroinflammation in vasculitic peripheral neuropathy induced by ischaemia–reperfusion via suppressing endoplasmic reticulum stress

Pan

Lin

Chuang

et al. 2019

Clin Exp Pharma Physio

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Vasculitic peripheral neuropathy (VPN) arises from an inflammatory obstruction in the blood vessels supplying peripheral nerves and subsequent ischaemic insults, which exhibits the clinical features of neuropathic pain and impaired peripheral nerve function. VPN induced by ischaemia–reperfusion (IR) has been reported to involve nuclear factor‐κB (NF‐κB)‐mediated neuroinflammation. Recent studies have suggested that endoplasmic reticulum (ER) stress has been implicated in the development of peripheral neuropathies. Resveratrol possesses a potent anti‐inflammatory capacity. We hypothesized that resveratrol may exert a protective effect against VPN through modulating the interrelated ER stress and NF‐κB pathways. Male Sprague‐Dawley rats were allocated into five groups: sham, sham + resveratrol 40 mg/kg (R40), IR, IR + R20 and IR + R40. VPN was induced by occluding the right femoral artery for 4 hours followed by reperfusion. Our data have shown that VPN induced by IR led to hind paw mechanical allodynia, heat hyperalgaesia, and impaired motor nerve conduction velocity (MNCV). With resveratrol intervention, the behavioural parameters were improved in a dose‐dependent manner and the MNCV levels were increased as well. The molecular data revealed that VPN induced by IR significantly increased the expression of NF‐κB as well as the ER stress sensor proteins, protein kinase RNA‐like endoplasmic reticulum kinase, inositol‐requiring enzyme 1 and activating transcription factor 6 in the sciatic nerves. More importantly, resveratrol significantly attenuated the expression of NF‐κB and the ER stress sensor proteins after IR. In conclusion, resveratrol alleviates VPN induced by IR. The mechanisms may involve modulating NF‐κB‐mediated neuroinflammation via suppressing ER stress.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%