Ischemic Skin Necrosis Secondary to the Use of Terlipressin

Nistal, María Reyes Busta; Cuadrado, Natalia Mora; Fernández-Salazar, Luis

doi:10.17235/reed.2020.7467/2020

Cited by 3 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The patient showed complete resolution of the rash and healed lesions within a week of follow-up, demonstrating the effectiveness of this approach. Discontinuation of terlipressin has shown complete resolution of necrosis of skin in various previous case reports [9][10][11][12].…”

Section: Discussionmentioning

confidence: 80%

Terlipressin-Induced Skin Necrosis While Managing Hepatorenal Syndrome: A Rare Case Report From North India

Sudan¹,

Chaudhary²,

Bethineedi³

et al. 2023

Cureus

View full text Add to dashboard Cite

Terlipressin is an analogue of vasopressin and is often used in the treatment of bleeding esophageal varices and also in the treatment of hepatorenal syndrome associated with liver cirrhosis. Although terlipressin is a safe drug, but it has been rarely associated with potentially serious adverse effects like ischemic necrosis of skin involving the abdominal skin, extremities, and scrotal skin. We present one such rare case where terlipressin-induced skin necrosis in bilateral lower extremities in a 48-year-old male while we were managing hepatorenal syndrome in the same.

show abstract

Section: Discussionmentioning

confidence: 80%

Terlipressin-Induced Skin Necrosis While Managing Hepatorenal Syndrome: A Rare Case Report From North India

Sudan¹,

Chaudhary²,

Bethineedi³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…Meanwhile, Saner et al treated hepatorenal syndrome and ascites with terlipressin and hydroxyethyl starch in a post-hemihepatectomy patient 14. While terlipressin is relatively safe compared with other vasoconstrictors, its rare adverse effects can be severe, including ischaemic skin necrosis,15–18 cardiac arrhythmias19 and hyponatraemia 20–22. These side effects could be dose dependent as they mostly develop days after treatment commencement.…”

Section: Discussionmentioning

confidence: 99%

Management of hepatic hydropericardium with open drainage, maximal medical therapy and terlipressin

Ermongkonchai,

Ha,

French

2024

BMJ Case Rep

View full text Add to dashboard Cite

We present the case of a woman in her 60s with Child-Pugh C cirrhosis who developed pericardial tamponade during an admission for a haemothorax secondary to a mechanical fall. The patient developed haemodynamic compromise with a rapid decline in renal function. During an open subxiphoid drain tube insertion, a pre-existing peritoneopericardial communication was noted, with ascites in the peritoneal cavity on view. The serum ascites albumin gradient was 14 g/L. Maximal medical therapy was commenced including diuresis and albumin, with adjunctive terlipressin infusion which restored her baseline renal function and resolved the effusion. We believe this is the first case report of using open drainage, maximal medical therapy and terlipressin to successfully treat hepatic hydropericardium and its subsequent renal compromise.

show abstract

Terlipressin

2021

Reactions Weekly

View full text Add to dashboard Cite

Ischemic Skin Necrosis Secondary to the Use of Terlipressin

Cited by 3 publications

References 4 publications

Terlipressin-Induced Skin Necrosis While Managing Hepatorenal Syndrome: A Rare Case Report From North India

Terlipressin-Induced Skin Necrosis While Managing Hepatorenal Syndrome: A Rare Case Report From North India

Management of hepatic hydropericardium with open drainage, maximal medical therapy and terlipressin

Terlipressin

Contact Info

Product

Resources

About