Ischemic Stroke and Sleep: The Linking Genetic Factors

Korostovtseva, Lyudmila

doi:10.1007/s40119-021-00231-9

Cited by 12 publications

(9 citation statements)

References 209 publications

(241 reference statements)

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“…For example, the mother's age and education level affected infant mortality ( 6 ). Many diseases, such as cardiovascular disease, diabetes and malignant tumors, are related to bad living habits and sleeping habits ( 7 – 9 ). Secondly, personal social networks also significantly affect personal health.…”

Section: Introductionmentioning

confidence: 99%

Study of the Economic, Environmental, and Social Factors Affecting Chinese Residents' Health Based on Machine Learning

Pan²,

Meng³

et al. 2022

Front. Public Health

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The Healthy China Strategy puts realistic demands for residents' health levels, but the reality is that various factors can affect health. In order to clarify which factors have a great impact on residents' health, based on China's provincial panel data from 2011 to 2018, this paper selects 17 characteristic variables from the three levels of economy, environment, and society and uses the XG boost algorithm and Random forest algorithm based on recursive feature elimination to determine the influencing variables. The results show that at the economic level, the number of industrial enterprises above designated size, industrial added value, population density, and per capita GDP have a greater impact on the health of residents. At the environmental level, coal consumption, energy consumption, total wastewater discharge, and solid waste discharge have a greater impact on the health level of residents. Therefore, the Chinese government should formulate targeted measures at both economic and environmental levels, which is of great significance to realizing the Healthy China strategy.

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Section: Introductionmentioning

confidence: 99%

Study of the Economic, Environmental, and Social Factors Affecting Chinese Residents' Health Based on Machine Learning

Pan²,

Meng³

et al. 2022

Front. Public Health

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“… 29 Besides, a Mendelian randomization analysis showed that short sleep duration and frequent insomnia symptoms are associated with a subtype of ischemic stroke. 30 Sleep deprivation may increase HDAC expression in the hippocampus, adversely affecting structural and functional synaptic plasticity and memory formation, leading to spatial memory decline, which could be reversed by HDAC inhibition. 31 Therefore, we hypothesized that HDAC9 is functionally involved in migraine and insomnia through the dysregulation of the cardiovascular system.…”

Section: Discussionmentioning

confidence: 99%

Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity

An¹,

Tsai²,

Liang³

et al. 2022

NSS

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Purpose Although insomnia and migraine are often comorbid, the genetic association between insomnia and migraine remains unclear. This study aimed to identify susceptibility loci associated with insomnia and migraine comorbidity. Patients and Methods We performed a genome-wide association study (GWAS) involving 1063 clinical outpatients at a tertiary hospital in Taiwan. Migraineurs with and without insomnia were genotyped using the Affymetrix Axiom Genome-Wide TWB 2.0. We performed association analyses for the entire cohort and stratified patients into the following subgroups: episodic migraine (EM), chronic migraine (CM), migraine with aura (MA), and migraine without aura (MoA). Potential correlations between SNPs and clinical indices in migraine patients with insomnia were examined using multivariate regression analysis. Results The SNP rs1178326 in the gene HDAC9 was significantly associated with insomnia. In the EM, CM, MA, and MoA subgroups, we identified 30 additional susceptibility loci. Multivariate regression analysis showed that SNP rs1178326 also correlated with higher migraine frequency and the Migraine Disability Assessment (MIDAS) questionnaire score. Finally, two SNPs that had been previously reported in a major insomnia GWAS were also significant in our migraineurs, showing a concordant effect. Conclusion In this GWAS, we identified several novel loci associated with insomnia in migraineurs in a Han Chinese population in Taiwan. These results provide insights into the possible genetic basis of insomnia and migraine comorbidity.

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“…The circadian system influences several cardiovascular risk factors, such as circulating catecholamine levels, blood pressure, heart rate, vagal modulation, platelet aggregability, and immune responses, thus having a possible impact on stroke risk [106]. Several circadian gene polymorphisms and haplotypes have been investigated as potential genetic risk factors of stroke [107]. Genes associated with a protective role against stroke were a single-nucleotide polymorphism of CLOCK gene [108] and PER1 and PER2 genes [109].…”

Section: Risk Factorsmentioning

confidence: 99%

“…Genes associated with a protective role against stroke were a single-nucleotide polymorphism of CLOCK gene [108] and PER1 and PER2 genes [109]. Genome-wide association studies demonstrated an association between genetic variants of melatonin receptors 2 and the risk of metabolic disorders, such as type 2 diabetes mellitus and insulin resistance, which may in turn increase the risk of stroke [107].…”

Section: Risk Factorsmentioning

confidence: 99%

“…Interestingly, a hyperdopaminergic tone in the putamen ipsilateral to the infarct was observed in all patients, except in one [143]. From a genetic point-of-view, direct evidence is rather scarce regarding the association between genes regulating dopaminergic neurotransmission, iron metabolism, and cardiovascular risk [107]. Some studies have argued that RLS is associated with a less favorable outcome of stroke [144,145]; however, larger studies are needed to confirm these data [13••].…”

Section: Consequence Of Stroke and Role On Stroke Recoverymentioning

confidence: 99%

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Sleep and Stroke: Opening Our Eyes to Current Knowledge of a Key Relationship

Brunetti

Rollo

Broccolini

et al. 2022

Curr Neurol Neurosci Rep

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Purpose of Review To elucidate the interconnection between sleep and stroke. Recent Findings Growing data support a bidirectional relationship between stroke and sleep. In particular, there is strong evidence that sleep-disordered breathing plays a pivotal role as risk factor and concur to worsening functional outcome. Conversely, for others sleep disorders (e.g., insomnia, restless legs syndrome, periodic limb movements of sleep, REM sleep behavior disorder), the evidence is weak. Moreover, sleep disturbances are highly prevalent also in chronic stroke and concur to worsening quality of life of patients. Promising novel technologies will probably allow, in a near future, to guarantee a screening of commonest sleep disturbances in a larger proportion of patients with stroke. Summary Sleep assessment and management should enter in the routinary evaluation of stroke patients, of both acute and chronic phase. Future research should focus on the efficacy of specific sleep intervention as a therapeutic option for stroke patients.

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Ischemic Stroke and Sleep: The Linking Genetic Factors

Cited by 12 publications

References 209 publications

Study of the Economic, Environmental, and Social Factors Affecting Chinese Residents' Health Based on Machine Learning

Study of the Economic, Environmental, and Social Factors Affecting Chinese Residents' Health Based on Machine Learning

Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity

Sleep and Stroke: Opening Our Eyes to Current Knowledge of a Key Relationship

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