Ischemic stroke in COVID-19 patients: a cross-sectional study from an Indonesian COVID-19 referral hospital

Hidayat, Rakhmad; Widjaya, Nita; Djuliannisaa, Zlatikha; Mustika, Alyssa Putri; Zairinal, Ramdinal Aviesena; Diafiri, Dinda; Mesiano, Taufik; Kurniawan, Mohammad; Rasyid, Al; Harris, Salim

doi:10.1186/s41983-022-00528-z

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…10 This is supported by research by Hidayat et al who reported an increase in D-dimer in 98.1% of stroke patients at the University of Indonesia Hospital. 11 In our study, the mean and median D-dimer were 5.36 mg/mL and 2.36 mg/mL, respectively, well above the normal value of 0.55 mg/mL. Yaghi et al in a New York study found similar results, confirming D-dimer with a median of 3.91 mg/mL in acute ischemic stroke patients with COVID-19.…”

Section: Discussionsupporting

confidence: 84%

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Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection

Amalia

2023

JBM

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Background Hypercoagulable state in acute ischemic stroke patients with COVID-19, was found to occur in most cases, may affect the severity and clinical outcome of acute ischemic stroke with COVID-19. Ischemic stroke patients with COVID-19 infection have worsen prognosis in mortality regarding hypercoagulable state condition. Objective The study aims to determine the relationship between the hypercoagulable state and the severity of acute ischemic stroke patients with COVID-19. Methods This study is a retrospective analytic study using a cross-sectional method in acute ischemic stroke who meet the criteria must have focal clinical symptoms or global dysfunction lasting more than 24 hours, be caused by vascular factors, be confirmed positive for COVID-19, NIHSS (admission and discharge), and have an examination of D-dimer and/or fibrinogen. Chi-Square is used for data processing relationship analysis. Results A total of 32 patients met the inclusion and exclusion criteria of this study. Elevated D-dimer and/or fibrinogen were found in 28 patients (87.5%), confirming a hypercoagulable state. In this study, the average value of D-dimer was 5.3 mg/mL, and fibrinogen was 479 mg/dL. Based on the admission NIHSS score, it was found that most of the patients had moderate strokes with an average NIHSS score of 12. The chi-square test results showed no relationship between the hypercoagulable state and the severity of acute ischemic stroke as measured by NIHSS admission (p=0.333), but it was closely related to NIHSS exit (p=0.02). The finding supports that 40.62% of acute ischemic stroke patients with COVID-19 confirmed to have a hypercoagulable state had a death discharge status. Conclusion There is no significant relationship between hypercoagulable state and stroke severity on admission, but it closely related to NIHSS on discharge and high mortality in acute ischemic stroke patients with COVID-19.

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Section: Discussionsupporting

confidence: 84%

“… 10 This is supported by research by Hidayat et al who reported an increase in D-dimer in 98.1% of stroke patients at the University of Indonesia Hospital. 11 …”

Section: Discussionmentioning

confidence: 99%

Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection

Amalia

2023

JBM

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“…Angka mortalitas dari pasien lansia pada penelitian sebelumnya (>65 tahun) yakni memiliki nilai risk ratio sebesar 62.1 (62 kali lebih berisiko terkena stroke iskemik). 7 Pada penelitian sebelumnya, didapatkan pasien lansia memiliki risiko lebih tinggi untuk terkena stroke iskemik dikarenakan faktor risiko yang mengasosiasi terjadinya stroke seperti atrial fibrilasi, skor NIHSS (National institutes of health stroke scale) tinggi, dan angka rawat inap lebih tinggi pada pasien lansia. Pasien lansia dengan stroke iskemik lebih sering disebabkan oleh kardioemboli, hal ini dikarenakan tingginya faktor risiko atrial fibrilasi pada pasien lansia.…”

Section: Pembahasanunclassified

Profil Pasien Stroke Dengan Covid-19 Di Rumah Sakit Soehadi Prijonegoro Sragen Periode 2021 – 2022

Setiawati,

Yulianti,

Sari, M.Sc, Sp.N

et al. 2024

BIKKM

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Latar Belakang: Stroke merupakan penyebab kematian tertinggi kedua secara global. Penyakit ini mempengaruhi pasien lanjut usia dan pasien usia muda terkadang tiap tahunnya. Berdasarkan Juli 2022, terdapat 575 juta orang terinfeksi Covid-19, dimana 6,39 juta di antaranya meninggal dunia. Tujuan: Penelitian ini bertujuan untuk mengetahui profil pasien stroke dengan dengan Covid-19 di Rumah Sakit Soehadi Prijonegoro Sragen Metode: Studi deskriptif menggunakan data sekunder pasien stroke dengan Covid-19 di Rumah Sakit Soehadi Prijonegoro Sragen periode Januari 2021-Desember 2022. Variabel yang dinilai terkait gambaran profil pasien meliputi usia, jenis kelamin, durasi rawat inap, keterangan keluar, dan D-Dimer. Hasil: Dari 22 subjek yang dilibatkan dalam penelitian ini, didapatkan hasil tertinggi pada setiap variabel yang diuji yaitu usia >60 tahun (57,1%), jenis kelamin perempuan (71,4%), durasi rawat inap 1-2 minggu (57,1%), kondisi keluar rumah sakit hidup (57,1%), kadar D-dimer <500 dan >1000 masing-masing memiliki persentase yang sama (38,1%). Simpulan: Profil pasien stroke dengan Covid-19 di Rumah Sakit Soehadi Prijonegoro Sragen didominasi oleh lansia (>60 tahun), jenis kelamin perempuan, durasi rawat inap 1-2 minggu, kondisi hidup saat keluar rumah sakit, dan kadar D-dimer yang tinggi

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“…6 A recent study on COVID-19-positive patients with ischemic stroke at the University of Indonesia Hospital in Depok found that the majority of patients are over the age of 55. 7 Several clinical studies showed that blood laboratory examinations may be correlated to a patient's prognosis. An increased white blood cell (WBC) count on admission has been correlated with increased mortality in stroke patients and could be used as a risk factor marker.…”

Section: Introductionmentioning

confidence: 99%

Ischemic Stroke Risk Factor Profile at Prof. Dr. W. Z. Johannes Hospital, Kupang, East Nusa Tenggara

Pramanasari

2024

AKSONA

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Highlight: Ischemic stroke is a major public health issue in Indonesia. Clinical data correlated to an ischemic stroke patient's prognosis. Several clinical factors and laboratory testing describe the tendency of ischemic stroke patients. ABSTRACT Introduction: In Indonesia, ischemic stroke is a major public health issue. Clinical data correlates with an ischemic stroke patient’s prognosis. Objective: This study aimed to provide an overview of clinical data in ischemic stroke patients from October 2020 to December 2021. Methods: This was a retrospective, descriptive study using medical records. A non-probability purposive sampling strategy with a total sampling method is used in this study. Age, gender, cardiac comorbidities, diabetes, repeated strokes, blood laboratory exams, electrolyte tests, alcohol consumption, and smoking habits were all observed variables. Results: The sample consisted of 242 ischemic stroke patients. The majority of patients (32.23%) were in the 61 to 70 age group, and men (57.4%) made up the majority of the sex group. Then, cardiac comorbidities were dominated by coronary artery disease (CAD), with 33 patients (57.4%) with 4 deaths (12.1%), while 15 patients (6.19%) were found with atrial fibrillation (AF), with 7 deaths (46.67%). Hypertension was found in 81.40% of patients, diabetes in 26.03% of patients, and recurrent stroke in 31.40% of patients. Active smokers make up 52.06% of all patients, and 18.18% are heavy alcohol drinkers. The majority of patients showed blood and electrolyte levels within the normal range, except for an increased leukocyte count and a decreased potassium level. Conclusion: The main risk factors obtained sequentially are hypertension, coronary artery diseases, active smokers, diabetes, and excessive alcohol consumption.

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Ischemic stroke in COVID-19 patients: a cross-sectional study from an Indonesian COVID-19 referral hospital

Cited by 7 publications

References 16 publications

Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection

Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection

Profil Pasien Stroke Dengan Covid-19 Di Rumah Sakit Soehadi Prijonegoro Sragen Periode 2021 – 2022

Ischemic Stroke Risk Factor Profile at Prof. Dr. W. Z. Johannes Hospital, Kupang, East Nusa Tenggara

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