Objective: Intravenous (IV) infusions are an essential part of hospital patient care, but Intravenous Infiltration in the process of the treatment. Leakage brought great pain to the patient; So far, no research has been done in this area. A simple and cheap method to relieve pain of IV infusions in this Study. Method: According to the accepted methods of treatment, all patients were divided into three groups randomly, Group A: Wash and dry the fresh potatoes. Group B:Apply the Hirudoid cream clockwise evenly and massage the puncture point within 5 to 8cm of the wound area. 20minutes three times a day. Group C: Saline flushes out and local cold. Patients in the three groups were treated with the same methods. Conclusion: Study shows 96.67% patient of Group A had recovered from symptoms, of redness and vein streaking dissipated, blood vessels returning to a normal condition. This study provides a method with frozen fresh potato chips in the treatment of symptoms of leakage.